“…Liver studies in rats and mice were characterized by alterations in serum biomarkers, but there was a lack of histopathologic correlation following whole-body inhalation exposure (10,11,12). Human neurological effects were characterized by acute symptoms of dizziness, headache, nausea, and fatigue; chronic symptoms were predominately neurasthenic effects of depression, lack of initiative, and memory impairment (8). In contrast to the vapor-only studies, 7-day subchronic exposures to aerosolized JP-8 in rats resulted in perivascular and interstitial edema, which were accompanied by leukocytic infiltration and morphological alterations to the distal lung (6).…”