Irreversible effects of trichloroethylene exposure on the central nervous system.

Kjellstrand, Per; Lanke, Jan; Bjerkemo, M; Zetterqvist, Lena; Månsson, Lennart

doi:10.5271/sjweh.2635

Cited by 38 publications

(11 citation statements)

References 16 publications

(12 reference statements)

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“…The seemingly enigmatic data of Kjellstrand et al (8) conform closely to what would be predicted from a theory of state-dependent learning (13). Recall of events or behavior learned under the influence of a drug is facilitated by a similar drug state during the test of retention.…”

Section: State-dependent Learningsupporting

confidence: 65%

“…The present data (8) indicate that trichloroethylene and 1,1, I-trichloroethane, both of which are chlorinated hydrocarbons, are capable of producing statedependent learning. The effect may be seen as rather weak, but significant , and very consistent and reproducible.…”

Section: State-dependent Learningmentioning

confidence: 74%

“…Kjellstrand et al (8) exposed mongolian gerbils to 320 ppm (1.72 g/m') of trichloroethylene continuously for nine months. During this period the spatial memory of the animals was trained and tested in a maze.…”

mentioning

confidence: 99%

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State-dependent learning during chronic trichloroethylene exposure.

Gade¹,

Jensen²

1985

Scand J Work Environ Health

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Section: State-dependent Learningsupporting

confidence: 65%

Section: State-dependent Learningmentioning

confidence: 74%

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State-dependent learning during chronic trichloroethylene exposure.

Gade¹,

Jensen²

1985

Scand J Work Environ Health

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“…The expo sure equipment has been de scribed in detail previously (8). PCE or I ,I,I-TCE (Uddeholm , Sweden) was mixed with ai r (2 200 II h) to the des ired concentration of 320 ppm ; for Freon II (Imperial Ch emical Industries, Great Britain) the con centration used was 580 ppm .…”

Section: Methodsmentioning

confidence: 99%

Effects of exposure to Freon 11, 1,1,1-trichloroethane or perchloroethylene on the lipid and fatty-acid composition of rat cerebral cortex.

Kyrklund¹,

Kjellstrand²,

Haglid³

1988

Scand J Work Environ Health

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Effects of exposure to Freon 11, 1,1,1-trichloroethane or perchloroethylene on the lipid and fatty-acid composition of rat cerebral cortex. by Kyrklund T, Kjellstrand P, Haglid KG Affiliation: Institute of Neurobiology, University of Goteborg, Sweden.This article in PubMed: www.ncbi.nlm.nih.gov/pubmed/3387963Effects of exposure to Freon 11, 1,1,1-trichloroethane or perchloroethylene on the lipid and fatty-acid composition of rat cerebral cortex by Titus Kyrklund , PhD,1 Per Kjellstrand , PhD,2 Kenneth G Haglid, MD, PhD 1 KYRKLUND T, KJELLSTRANDP, HAGLID KG. Effects of exposure to Freon u , i , I, i-trichloroethane or perchloroethyleneon the lipid and fatty-acid compositionof rat cerebral cortex. Scand J Work Environ Health 14 (1988)91-94. Organic solvents are often present as mixtures in various industrial and household products. The adverse effects arising from exposure to these solvents have often been generalized to concern the whole group of solvents. in an examination of the possibility that organic solvents have general effects on experimental animals, rats were continuously exposed to vapors of the halogenated solvents Freon II , pcrchloroethylene, and l ,I, l-trichloroethane. The lipidcomposition and fatty-acid pattern of ethanolamine phosphoglyceride from the cerebral cortex were analyzed. It was observed that only perchloroethylene had effects on the brain lipidcomposition. Cholesterol and total phospholipids wereslightly reduced. Among the fatty acids the proportion of stearic acid was reduced and those of docosapentanoic, 22: 5 (N =6), and of docosahexanoic, 22: 6 (N =3), acids were increased. The changes in the fatty-acid pattern indicate that an alteration occurs in the desaturation of fatty acids. It seems probable that the chloroethylenes have specific effects on the fatty-acid pattern of brain phospholipids not shared by other solvents.

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“…In a letter to the Editor, published in volume 11, number 6 (pp 495-497) of the Scandinavian Journal of Work Environment & Health, Drs A Gade & HH Jensen, from the University of Copenhagen, referred to an article by myself and collaborators (4). The article is used by Gade & Jensen as an example of how readily "state-dependent learning" can cause misinterpretation in experiments in which behavior is used in exploring effects on the central nervous system.…”

Section: Comment On the Interpretation Of Effects Caused By Chronic Tmentioning

confidence: 99%

Irreversible effects of trichloroethylene exposure on the central nervous system.

Abstract: The following articles refer to this text: 1986;12(2):0; 1985;11(6):0

Cited by 38 publications

References 16 publications

State-dependent learning during chronic trichloroethylene exposure.

State-dependent learning during chronic trichloroethylene exposure.

Effects of exposure to Freon 11, 1,1,1-trichloroethane or perchloroethylene on the lipid and fatty-acid composition of rat cerebral cortex.

Comment on the interpretation of effects caused by chronic trichloroethylene exposure.

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