Localized delivery of FTY-720 from 3D printed cell-laden gelatin/silk fibroin composite scaffolds for enhanced vascularized bone regeneration

Jin, Yang; Deng, Changxu; Shafiq, Muhammad; Li, Zhihui; Zhang, Qianqian; Du, Haibo; Li, Shikai; Zhou, Xiaojun; He, Chuanglong

doi:10.1016/j.smaim.2022.01.007

Cited by 36 publications

(27 citation statements)

References 32 publications

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“…They prepared the 3D bioprinted scaffold based on GeiMA/SFMA bioink with Bone marrow stromal cells (BMSCs) and fingolimod (FTY-720) drugs for the combined actions of osteogenesis and vascularization at the time of bone repair. The bioinks exhibited potential advantages in this study because of their adjustable rheology, rapid photo-crosslinking, and enhanced structure reliability following bioprinting to form BMSCs/FTY/G-S ( Figure 3 ) [ 145 ]. This proposes that it is essential to integrate different bioprinting technologies to attain the required mechanical strength for bone tissue engineering.…”

Section: Applications Of 3d Bioprinting Based On Silk Fibroinmentioning

confidence: 99%

Recent Developments of Silk-Based Scaffolds for Tissue Engineering and Regenerative Medicine Applications: A Special Focus on the Advancement of 3D Printing

Shabbirahmed

Sekar²,

Gomez

et al. 2023

Biomimetics

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Regenerative medicine has received potential attention around the globe, with improving cell performances, one of the necessary ideas for the advancements of regenerative medicine. It is crucial to enhance cell performances in the physiological system for drug release studies because the variation in cell environments between in vitro and in vivo develops a loop in drug estimation. On the other hand, tissue engineering is a potential path to integrate cells with scaffold biomaterials and produce growth factors to regenerate organs. Scaffold biomaterials are a prototype for tissue production and perform vital functions in tissue engineering. Silk fibroin is a natural fibrous polymer with significant usage in regenerative medicine because of the growing interest in leftovers for silk biomaterials in tissue engineering. Among various natural biopolymer-based biomaterials, silk fibroin-based biomaterials have attracted significant attention due to their outstanding mechanical properties, biocompatibility, hemocompatibility, and biodegradability for regenerative medicine and scaffold applications. This review article focused on highlighting the recent advancements of 3D printing in silk fibroin scaffold technologies for regenerative medicine and tissue engineering.

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Section: Applications Of 3d Bioprinting Based On Silk Fibroinmentioning

confidence: 99%

Recent Developments of Silk-Based Scaffolds for Tissue Engineering and Regenerative Medicine Applications: A Special Focus on the Advancement of 3D Printing

Shabbirahmed

Sekar²,

Gomez

et al. 2023

Biomimetics

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“…Hydrogel materials have good application value in ensuring the activity of growth factors and stem cells. 29,30 Therefore, as a kind of injectable hydrogel, the S1P@MSNs/ AHA/NOCC hydrogel could serve as a drug release system to improve the bioactivity of implants by a simple combination between the hydrogel and other implants (Fig. 7A).…”

Section: Subcutaneous Embeddingmentioning

confidence: 99%

Vascularized nanocomposite hydrogel mechanically reinforced by polyelectrolyte-modified nanoparticles

et al. 2022

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“…[21] Besides, silk-based biomaterials are effective carriers of growth factors stimulating vascularization in the osseous tissue. [22,23,24] Synthetic polymers such as poly (lactic acid), poly(glycolic acid), and polycaprolactone (PCL) have also received attention in the development of the vascularised network in bone regeneration largely attributable to their better mechanical properties in comparison to the natural polymers. [25,26,27]…”

Section: Synthetic and Natural Compounds/polymersmentioning

confidence: 99%

Strategies for Enhancing Vascularization of Biomaterial‐Based Scaffold in Bone Regeneration

Nambiar

Jana

Nandi

2022

The Chemical Record

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Despite the recent advances in reconstructive orthopedics; fracture union is a challenge to bone regeneration. Concurrent angiogenesis is a complex process governed by events, delicately entwined with osteogenesis. However, poorly perfused scaffolds have lower success rates; necessitating the need for a better vascular component, which is important for the delivery of nutrients, oxygen, waste elimination, recruitment of cells for optimal bone repair. This review highlights the latest strategies to promote biomaterial-based scaffold vascularization by incorporation of cells, growth factors, inorganic ions, etc. into natural or synthetic polymers, ceramic materials, or composites of organic and inorganic compounds. Furthermore, it emphasizes structural modifications, biophysical stimuli, and natural molecules to fabricate scaffolds aiding the genesis of dense vascularization following their implantation to manifest a compatible regenerative microenvironment without graft rejection.

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Localized delivery of FTY-720 from 3D printed cell-laden gelatin/silk fibroin composite scaffolds for enhanced vascularized bone regeneration

Cited by 36 publications

References 32 publications

Recent Developments of Silk-Based Scaffolds for Tissue Engineering and Regenerative Medicine Applications: A Special Focus on the Advancement of 3D Printing

Recent Developments of Silk-Based Scaffolds for Tissue Engineering and Regenerative Medicine Applications: A Special Focus on the Advancement of 3D Printing

Vascularized nanocomposite hydrogel mechanically reinforced by polyelectrolyte-modified nanoparticles

Strategies for Enhancing Vascularization of Biomaterial‐Based Scaffold in Bone Regeneration

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