Vascularized nanocomposite hydrogel mechanically reinforced by polyelectrolyte-modified nanoparticles

Zhang, Qianqian; Pei, Qingguo; Jin, Yang; Guo, Shuting; Ai, Yang; Qian, Yuhan; Li, Chenglin; Qian, Feng; Lv, Houchen; Zhou, Xiaojun; He, Chuanglong

doi:10.1039/d2tb00735e

Cited by 16 publications

(27 citation statements)

References 30 publications

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“…The tensile test also showed that the tensile strength of the hydrogel could reach 23 kPa, and the elongation rate was 160% after photocrosslinking. Due to the reinforcement of nanoparticles, , after the introduction of PDA nanoparticles, the tensile strength of the hydrogel was increased to 33 kPa, and the elongation ratio was increased to 220% (Figure d). In addition, the PS 12 -OSA 1 -P 0.03 hydrogel showed highly overlapping curves in the cyclic loading–unloading test, with a small hysteresis loop, and exhibited a high elasticity (Figure e).…”

Section: Resultsmentioning

confidence: 99%

Injectable In Situ Photocrosslinked Hydrogel Dressing for Infected Wound Healing

Zhang

Dong

Jing

et al. 2023

ACS Appl. Bio Mater.

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A traditional injectable photocrosslinked hydrogel had disadvantages of the residual photoinitiator and toxic crosslinker, slow in situ curing, and a complex preparation process. At the same time, hydrogels cannot act as artificial skin to restore skin sensory function during the wound healing cycle. In this work, an injectable photocrosslinked hydrogel was prepared which can be quickly in situ cured without photoinitiator. Oxidized sodium alginate was used as a natural macromolecular crosslinking agent to form an injectable hydrogel framework with the photosensitive polymer polyvinyl alcohol bearing styrylpyridinium group (PVA-SBQ). In addition, the hydrogel was endowed with photothermal therapy property after the introduction of biomass-like polydopamine particles. When used as a wound dressing, the hydrogel exhibited an excellent antibacterial property, with an antibacterial rate of 99.56% Escherichia coli and 97.96% Staphylococcus aureus. As a result, the hydrogel could significantly accelerate the repair of infected wounds, with a wound healing rate of 96.45% after 14 days. Moreover, the hydrogel exhibited a sensitive and stable sensing property, making it promising to reconstitute the sensory function of damaged skin during treatment. This work provides an idea for the development of injectable photocrosslinked hydrogel dressing.

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Section: Resultsmentioning

confidence: 99%

Injectable In Situ Photocrosslinked Hydrogel Dressing for Infected Wound Healing

Zhang

Dong

Jing

et al. 2023

ACS Appl. Bio Mater.

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“…In chemical reaction method, the functional groups in the molecular chain of a polymer react with each other to form covalent bonds; examples include the thiololefn click reaction [ 100 ], Schiff base reaction [ 78 ], free-radical polymerization [ 101 ], and hybridization chain reaction [ 31 ]. A gel formed by chemical crosslinking has higher mechanical properties and no melting or dissolving.…”

Section: Crosslinking Methods Of Mesoporous Material-loaded Composite...mentioning

confidence: 99%

“…Carboxylated mesoporous silica loaded into a gelatin methacryloyl hydrogel not only increased the mechanical strength, compressive modulus, and swelling ratio of the hydrogel, but also led to a controlled release of metformin, endowing the hydrogel with better biocompatibility, antibacterial activity, and superior stem cell adhesion and proliferation induction [ 77 ]. The alginate/chitosan polyelectrolyte-modified mesoporous silica nanoparticles also improved the mechanical properties of aldehyde hyaluronic acid/N, O-carboxymethyl chitosan hydrogels and achieved sustained drug release due to the Schiff base reaction between the aldehyde group in aldehyde hyaluronic acid and the amino group in chitosan [ 78 ].…”

Section: Classification Of Mesoporous Material-loaded Composite Hydro...mentioning

confidence: 99%

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

Chen

Qiu

Xia

et al. 2023

Gels

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Scientists have been attempting to improve the properties of mesoporous materials and expand their application since the 1990s, and the combination with hydrogels, macromolecular biological materials, is one of the research focuses currently. Uniform mesoporous structure, high specific surface area, good biocompatibility, and biodegradability make the combined use of mesoporous materials more suitable for the sustained release of loaded drugs than single hydrogels. As a joint result, they can achieve tumor targeting, tumor environment stimulation responsiveness, and multiple therapeutic platforms such as photothermal therapy and photodynamic therapy. Due to the photothermal conversion ability, mesoporous materials can significantly improve the antibacterial ability of hydrogels and offer a novel photocatalytic antibacterial mode. In bone repair systems, mesoporous materials remarkably strengthen the mineralization and mechanical properties of hydrogels, aside from being used as drug carriers to load and release various bioactivators to promote osteogenesis. In hemostasis, mesoporous materials greatly elevate the water absorption rate of hydrogels, enhance the mechanical strength of the blood clot, and dramatically shorten the bleeding time. As for wound healing and tissue regeneration, incorporating mesoporous materials can be promising for enhancing vessel formation and cell proliferation of hydrogels. In this paper, we introduce the classification and preparation methods of mesoporous material-loaded composite hydrogels and highlight the applications of composite hydrogels in drug delivery, tumor therapy, antibacterial treatment, osteogenesis, hemostasis, and wound healing. We also summarize the latest research progress and point out future research directions. After searching, no research reporting these contents was found.

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“…ELISA 4,97,115,168 28.6% HPLC 120 7.1% Weight measurements of drug 106 7.1% Drug specific testing BCA protein assay−used commonly for BSA loading 92,130 14.3%…”

Section: 7%mentioning

confidence: 99%

The Diamond Concept Enigma: Recent Trends of Its Implementation in Cross-linked Chitosan-Based Scaffolds for Bone Tissue Engineering

Agnes

Karoichan

Tabrizian

2023

ACS Appl. Bio Mater.

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An increasing number of publications over the past ten years have focused on the development of chitosan-based cross-linked scaffolds to regenerate bone tissue. The design of biomaterials for bone tissue engineering applications relies heavily on the ideals set forth by a polytherapy approach called the “Diamond Concept”. This methodology takes into consideration the mechanical environment, scaffold properties, osteogenic and angiogenic potential of cells, and benefits of osteoinductive mediator encapsulation. The following review presents a comprehensive summarization of recent trends in chitosan-based cross-linked scaffold development within the scope of the Diamond Concept, particularly for nonload-bearing bone repair. A standardized methodology for material characterization, along with assessment of in vitro and in vivo potential for bone regeneration, is presented based on approaches in the literature, and future directions of the field are discussed.

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Vascularized nanocomposite hydrogel mechanically reinforced by polyelectrolyte-modified nanoparticles

Abstract: Vascularization plays an important role in the initial stage of triggering the bone defects repair. The combination of bioactive small molecule drugs and biomaterials has been a powerful strategy for...

Cited by 16 publications

References 30 publications

Injectable In Situ Photocrosslinked Hydrogel Dressing for Infected Wound Healing

Injectable In Situ Photocrosslinked Hydrogel Dressing for Infected Wound Healing

Mesoporous Materials Make Hydrogels More Powerful in Biomedicine

The Diamond Concept Enigma: Recent Trends of Its Implementation in Cross-linked Chitosan-Based Scaffolds for Bone Tissue Engineering

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