Local Anesthesia - Solution to Pain : An Overview

For various reasons, the balance between oxidative stress and the antioxidative defence system is disturbed during general anesthesia. On the other hand, thanks to their antioxidant effect, certain anesthetics have been suggested to protect from oxidative stress caused due to pathological states. In this study, potential antimicrobial and antioxidative activities of commonly used anesthetic drugs were evaluated to reveal possible effects after surgery. The antimicrobial activities of commercially purchased anesthetic drugs diluted with sterile physiological saline were investigated according to the Kirby-Bauer disc diffusion method. Furthermore, minimum inhibitory concentration and minimum bactericidal concentrations were determined. Antioxidative potentials of the drugs were screened according to 2,2 diphenyl-1-picrylhydrazyl (DPPH) and hydroxyl (OH●) radical scavenging assays. One of the tested drugs, Ketalar, containing ketamine hydrochloride was found to have an inhibition effect on all tested pathogenic microorganisms. At the same time, Mivacron and Pental Sodium formed the most significant inhibition zones on Micrococcus luteus. As expected, Propofol had no antimicrobial activity on most tested organisms. However, its antioxidant activity was the highest among the other drugs. Calculated SC50 values for DPPH-free and hydroxyl radical scavenging activities of Ultiva, Blok-L, and Zolamid were very close to Propofol. It can be concluded that using these drugs for anesthesia may suppress the risk of contamination and oxidative stress that may occur during use in many cases.

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“…Since the introduction of cocaine in 1884, anesthetic drugs have been used to withstand pain (Jaan et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Determination of Antimicrobial and Antioxidative Properties of Several Anesthetic Drugs

et al. 2023

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“…Soluble surface anaesthetics include Cocaine, Tetracaine. Benoxinate, Lignocaine whereas insoluble surface anaesthetics include Benzocaine, Oxethazine [5] .…”

Section: ) Based On the Presence Or Absence Of Vasoconstrictors They ...mentioning

confidence: 99%

“…Ester type of local anaesthetic possesses an ester linkage between the benzene ring and the intermediate chain, whereas the amide type of local anaesthetics contains an amide linkage between them [5] . Classification is described as a flowchart in Figure 2.…”

Section: ) Based On the Chemical Structurementioning

confidence: 99%

Local Anaesthesia in Periodontics - A Brief Review

Arulmari

Athul

Ashwath

2023

Int J Health Sci Res

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Pain is an unpleasant sensory and emotional experience of varying degrees often caused by biological, social and psychological factors. Local anesthetics are amphipathic molecules that when administered in sufficient concentration, inhibit pain transmission. As the administration of local anesthetics is inevitable in routine dental treatments, in-depth knowledge about local anesthesia, its effects on the body and how the body reacts to the drug is of paramount importance. This review article highlights the key aspects of local anesthesia including its role in periodontal therapy. Key words: Dental pain, Local Anesthesia, LA in Periodontics, LA techniques, Lidocaine, Epinephrine.

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“…Dalam konteks pembedahan, anestesi lokal menciptakan tidak adanya rasa sakit di lokasi tertentu dari tubuh tanpa kehilangan kesadaran, berbeda dengan anestesi umum. Ketika digunakan pada jalur saraf tertentu (blok saraf anestesi lokal), kelumpuhan (kehilangan kekuatan otot) juga dapat dicapai (Jaan et al, 2020).…”

Section: Teknik Lokal Intra-artikular Atau Topikalunclassified

Manajemen Nyeri Pasca Operasi : Tinjauan Pustaka

Yuliana¹,

Silitonga²,

Wahyuni³

2022

nutrient

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Nyeri pascaoperasi adalah pengalaman multifaktorial individu yang dipengaruhi oleh budaya pasien, psikologi, genetika, kejadian nyeri sebelumnya, keyakinan, suasana hati, dan kemampuan untuk mengatasinya, serta jenis prosedur yang dilakukan. Pengobatan nyeri pasca operasi yang tidak memadai terus terjadi, meskipun ada kemajuan dalam teknik analgesik, menempatkan pasien pada risiko kecacatan yang signifikan. Manajemen nyeri pasca operasi yang optimal dihasilkan dari penatalaksanaan yang tepat pada periode pra operasi, intraoperatif, dan pasca. Pemahaman tentang patofisiologi nyeri pasca operasi dan berbagai pilihan yang tersedia untuk analgesia sering menghasilkan pendekatan multimodal yang spesifik prosedur, mengoptimalkan penghilang rasa sakit, mengurangi efek samping, dan menciptakan pengalaman pasien yang lebih baik. Tinjauan pustaka ini membahas tentang manajemen nyeri pasca operasi dan metode apa yang dapat mendukung pengurangan terhadap nyeri.

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Local Anesthesia - Solution to Pain : An Overview

Cited by 5 publications

References 17 publications

Determination of Antimicrobial and Antioxidative Properties of Several Anesthetic Drugs

Determination of Antimicrobial and Antioxidative Properties of Several Anesthetic Drugs

Local Anaesthesia in Periodontics - A Brief Review

Manajemen Nyeri Pasca Operasi : Tinjauan Pustaka

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