Liver disease in the UK

Hirschfield, Gideon M.; Thain, Collette; Walmsley, Martine; Brownlee, Ann; Jones, David

doi:10.1016/s0140-6736(15)60192-1

Cited by 9 publications

(6 citation statements)

References 2 publications

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“…The liver plays a vital role in physiological functions that include oxidation, reduction, hydrolysis, conjugations, sulfation and acetylation in detoxification along with carbohydrate, lipid and protein metabolism of the body [1,2] . If it did not function normally to regulate body metabolism, which reflects in alterations in different enzymes, hormones and proteins levels [3,4] . This will affect the health conditions of the human or any living organism leading to mortality [5] .…”

Section: Research Papermentioning

confidence: 99%

Evaluation of Hepatoprotective Activity of Zanthoxylum armatum on Paracetamol-induced Liver Toxicity in Rats

Talluri¹,

Gummadi²,

Battu³

et al. 2019

pharmaceutical-sciences

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Section: Research Papermentioning

confidence: 99%

Evaluation of Hepatoprotective Activity of Zanthoxylum armatum on Paracetamol-induced Liver Toxicity in Rats

Talluri¹,

Gummadi²,

Battu³

et al. 2019

pharmaceutical-sciences

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“…Some would argue that palliative and end-of-life care is one of the greatest unmet needs in hepatology. 11 Much needs to be done: the NCEPOD report and the Lancet Commission provide a road map on how to reduce alcoholrelated mortality and improve the care of patients with chronic liver disease.…”

Section: Editorialmentioning

confidence: 99%

Tackling the Epidemic: The Ncepod Report on Alcohol-Related Liver Disease and the Lancet Commission on Liver Disease

Kiat

O’Mahony

2018

Journal of the Royal College of Physicians of Edinburgh

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“…If any injuries happen to liver, it impacts the normal body physiological parameters such as enzymes levels, protein content, imbalance in detoxification etc., and finally leads to mortality [4]. Now a days, liver diseases have been increasing around the world due to different reasons like uncontrolled diet, lack of exercise, emerging of new diseases, pollution, chemicals, inadequate usage, because of side effects from current day drugs and also alcoholic consumption [5,6]. Now a days, alcohol consumption is very common around the world but, excessive consumption is causing a global problem with enormous economic, social and clinical consequences [7].…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Activity of Acampe praemorsa

Uppala

Rao

Reddy

et al. 2021

JPRI

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Introduction: Liver is one of major functional organ in body, its damage can alter body metabolisms and other organs’ function. So, it is very important to maintain the healthy liver. Now a days, different chemicals and inadequate use of medicines are causing liver impairments including alcohol consumption. There is a need to identify safe hepatoprotective drugs against liver diseases from different natural resources including medicinal plants. Several medicinal plants have been using in traditional medicines against several diseases including liver disease and many of them are not scientifically proven. So, the current study was aimed to evaluate hepatoprotective nature of Acampe praemorsa. Methodology: The hepatoprotective activity of A. praemorsa was carried on ethanol-induced liver toxicity on albino wistar rats by evaluating the levels of liver biomarker enzymes such as aspartate aminotransferase (AST), Alanine transaminase (ALT), Alkaline phosphatase (ALP), Total protein (T.ptn), and Total bilirubin (T.Bil). Results: The extracts of Acampe praemorsa were found to be safe at different doses as there were no mortality and physio-psychological changes observed in toxicity study. The extracts of Acampe praemorsa has showed dose dependent hepatoprotective activity on controlling the altered liver biomarker enzymes when compared along with standard drug Liv 52. The hydroalcoholic extract showed better activity compared to ethyl acetate extracts. The percentage protection on liver biomarker enzymes levels of hydro-alcoholic extract at 100, 200, and 400 mg/kg on AST, ALT, ALP, T.ptn, and T.Bil was found to be 62.72%, 60.06%, 61.77%, 63.96% and 58.58% respectively. Conclusion: The results of recent study support traditional medicinal use of Acampe praemorsa and provides the information about its’ hepatoprotective nature. The hepatoprotective activity of A. praemorsa was definitely due to presence of different phytochemical compounds in it as it was compared with Liv 52 which was also an herbal drug.

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Liver disease in the UK

Cited by 9 publications

References 2 publications

Evaluation of Hepatoprotective Activity of Zanthoxylum armatum on Paracetamol-induced Liver Toxicity in Rats

Evaluation of Hepatoprotective Activity of Zanthoxylum armatum on Paracetamol-induced Liver Toxicity in Rats

Tackling the Epidemic: The Ncepod Report on Alcohol-Related Liver Disease and the Lancet Commission on Liver Disease

Hepatoprotective Activity of Acampe praemorsa

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