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Liver is one of the most important organ in the human body, it performs fundamental metabolisms in the body those include homeostasis, carbohydrates, proteins, lipids metabolisms and mainly detoxification. 1-2 It is important to maintain healthy liver for good health conditions. The present day life style causing different illness including liver diseases. 3 The drugs using for the present day diseases getting resistant to them and may cause side effects which can lead to iatrogenic diseases. The drugs mainly inducing the vital organs damage in the body like kidney, liver etc. 4-6 The druginduced liver diseases are more common compared to natural liver diseases around the world. 7-8 The liver diseases like cirrhosis, cancers, alcoholic liver diseases and non-alcoholic liver diseases are main causes for the liver failure and causing mortality around the world. 9 The development in modern medicine developed many medication for treatment many diseases including liver diseases. 10-12 But, these treatments are not satisfactory and as said above on the long-term usage of drugs causing different side effects. 13 So, there

The present study was aimed to evaluate the antioxidant activity traditional medicinal plant, Borassus flabellifer. The root/rhizome part of plant was used for preparation of extracts using maceration process using different solvents. The extracts of plants were studied for free radical scavenging activity on 2, 2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl and superoxide free radicals and antioxidant capacity was studied using ferric thiocyanate (FTC) method. The selected plant extracts showed the concentration dependent percentage inhibition on tested free radicals. The extracts showed the good scavenging activity on DPPH free radical and less on hydroxyl free radical. The methanol extract of the Borassus flabellifer showed the good percentage inhibition on tested free radicals compared to other extracts and is comparable with the ascorbic acid. The results of the FTC method also showed that the selected plant extracts have antioxidant capacity. The extracts of selected plants showed the lower absorbance compared to the control. The methanol extract reduced the amounts of peroxides from the linolenic acid oxidation with the percentage of 53.17 on 7th day of FTC method.

Objective: Borassus flabellifer is an doub palm tree, different parts of it have been using as food and in traditional medicine. The root parts (rhizomes) are used for phytochemical analysis and evaluation of hepatoprotective and anti-tuberculosis activities.Materials: Hepatoprotective activity of Borassus flabellifer root extracts were studied on paracetamol-induced liver toxicity in rats and anti-tuberculosis activity on Mycobacterium tuberculosis [H37 Rv strain] quantitative determination using Microplate Alamar Blue assay (MABA) method.Results: The phytochemical analysis of different extracts B. flabellifer roots showed the presence of sterols, terpenoids, glycosides, carbohydrates, proteins, flavanoids, alkaloids, phenols, tannins, saponins and oils. The methanolic extract showed more phenolic and alkaloid contents on their quantification. Ethyl Acetate, Chloroform and Methanol extracts of B. flabellifer showed the dose dependent percentage protection of on paracetamol-induced liver toxicity. The methanol extract showed more activity and is comparable with standard drug Liv 52 on altered liver biomarker enzymes AST (SGOT), ALT (SGPT), ALP, total bilirubin and total protein levels with percentage protection 70.58%, 68.91%, 69.30% 71.18% and 70.73%. The ethyl acetate extract showed more anti-tuberculosis activity than methanol extract with MIC 6.25μg/mL but the extracts showed lower activity compared to standard drugs ciprofloxacin, Streptomycin and pyrazinamide of the MIC values are 6.25, 3.125, 3.125 μg/mL.Conclusion: B. flabellifer roots posses different phytochemical constituents and those extracts posses hepatoprotective and anti-tuberculosis activities