Evaluation of Hepatoprotective Activity of Zanthoxylum armatum on Paracetamol-induced Liver Toxicity in Rats

Talluri, Mallikarjuna Rao; Gummadi, Veda Priya; Battu, Ganga Rao; Killari, K. N.

doi:10.4172/pharmaceutical-sciences.1000489

Cited by 14 publications

(12 citation statements)

References 41 publications

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“…The formation of free radicals (FRs) will be more effective in several diseases through liver toxicity. The developed FRs are unbalanced molecules, during their stabilization alter the physiological function of organs, including liver functions, by reacts with stable molecules and finally lead to oxidative stress (OS) [27,40,41]. The OS can cause unusual diseases like lipid peroxidation, DNA damage, atherosclorosis, cancers, neurodegenerative, inflammatory bowel diseases and accelerated aging [42].…”

Section: Resultsmentioning

confidence: 99%

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Phytochemical Analysis, Antioxidant and Hepatoprotective Activity of Actiniopteris Radiata

Sankar

Venkateswarlu

2020

Int J Pharm Pharm Sci

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Objective: The medicinal plants have been using to treat ailments since ancient times. The recent advances in science and technology impel humans to evaluate medicinal plants therapeutic efficiency and isolation of bioactive compounds in pure forms before their use in development of new drugs and their derivatives. But even now, abundant medicinal plants unevaluated scientifically. The current study was aimed to explore phytochemical constituents, antioxidant and hepatoprotective activities of Actiniopteris radiata root parts. Methods: Standard procedures have been used to perform phytochemical analysis. Antioxidant activity was carried using In vitro methods on superoxide, hydroxyl, and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals. Hepatoprotective activity was studied by paracetamol-induced liver toxicity on WISTAR albino rats. The parameters assessed were Aspartate aminotransferase (SGOT/AST), Alanine aminotransferase (SGPT/ALT), alkaline phosphatase (ALP) and total bilirubin levels. Results: The tested extracts (hexane, ethyl acetate, and hydro-alcoholic) possess biologically active compounds such as sterols, terpenoids, glycosides, phenolics, alkaloids, flavonoids. The hydro-alcoholic extract has more phenolic contents (24.28±0.3) and flavonoid contents (22.68±0.6). The extracts showed dose dependent activity on tested free radicals and extracts showed more percentage inhibition at 320µg. The hydro-alcoholic extract showed more percentage inhibition i.e. 71.00±2.08 on DPPH free radical, 79.67±1.20 on hydroxyl free radical and 80.33±1.20 on superoxide free radical. As antioxidant activity of hexane and ethyl acetate extracts was less and they also showed less percentage protection on liver toxicity, hydro-alcoholic extract showed more percentage protection on biomedical enzyme levels of liver toxicity at high concentration i.e., 400 mg/kg b.w. The percentage protection on the enhancement of AST (SGOT), ALT (SGPT), ALP, and total bilirubin levels were 82.24%, 82.14%, 84.18%, and 82.85% are significant (P<0.01) as Liv52 shown percentage protection on the enhancement of Aspartate aminotransferase (SGOT), alanine aminotransferase (SGPT), Alkaline phosphatase (ALP) and total bilirubin levels were 93.58%, 92.83%, 94.67% and 93.57%. Conclusion: The current study was aimed to explore phytochemical constituents, antioxidant and hepatoprotective activities of Actiniopteris radiata root parts extracts. The outcome of the current research results provides scientific evidence of the traditional usage of Actiniopteris radiata.

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Section: Resultsmentioning

confidence: 99%

“…The collected samples were centrifuged without any delay at 2400rpm/15 min. The separated serum was used to evaluate the liver function parameters such as Aspartate aminotransferase (SGOT), alanine aminotransferase (SGPT), Alkaline phosphatase (ALP) and total bilirubin levels using an auto analyzer [4,27].…”

Section: Hepatoprotective Activitymentioning

confidence: 99%

Phytochemical Analysis, Antioxidant and Hepatoprotective Activity of Actiniopteris Radiata

Sankar

Venkateswarlu

2020

Int J Pharm Pharm Sci

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“…In a different study, the EE of bark of Z. armatum significantly expressed hepatoprotective activity at concentrations of 100, 200, and 400 mg/kg when administered orally in Wistar albino rats (where liver damage was instigated by paracetamol) by decreasing the levels of hepatic enzymes, bilirubin and at the same time increasing catalase, superoxide dismutase, and glutathione in comparison to silymarin [88]. In a recent study the ME at a dose of 500 mg/kg exhibited successful hepatoprotective activity with 66.87, 64.84, 67.95, 60.76, and 65.85% protection on aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total bilirubin, and total protein enzyme levels of the liver, respectively in Wistar rats [89].…”

Section: Hepatoprotective Activitymentioning

confidence: 97%

An Overview of Genus Zanthoxylum with Special Reference to Its Herbal Significance and Application

Ekka¹,

Jadhav²,

Quraishi³

2020

Herbs and Spices

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The plants of genus Zanthoxylum are effectually utilized in conventional and present-day medicine system to fight many diseases and disorders like pain, seizures, inflammation, cancer, liver and heart malady. Many of its plants-trees and shrubs, are citrus in nature, with curative antimicrobial, antihelminthic, antipyretic, and antiviral activities. More than 100 of its plant species have been identified and recorded for their potential as an herb in modern pharmacopeia. The species of this genus also have potent ethno-pharmacological significance. Many medicinal secondary metabolites like terpenoids, flavonoids, and alkaloids have also been profiled in many Zanthoxylum species. Additionally, fruit of many of the species is also significantly utilized as a major spice under the name "Sichuan pepper" in many countries like China and India. Thus, this unique blend of herb and spice characteristic of the genus needs a detailed description. This chapter highlights the major significant discoveries in the recent decade in this genus, which can add a step in the way of development of herbal medicines. Documentation of such medicinal plants may aid in derivation of plant-based medicines, which is the demand of the hour.

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“…This protection was evidenced by the modulation of parameters of liver status in serum and histological examinations of hepatic tissues of rats that received the extract. In addition, ethyl acetate, chloroform, and methanol extracts of Z. armatum root were evaluated for their ability to prevent paracetamol-mediated hepatic damage in rats and results showed that methanol extract showed the highest hepatoprotective activity, which was related to its high total phenolic content compared to other extracts [ 177 ]. Activity-guided fractionation identified lupeol as the active ingredient responsible for the hepatoprotective effects of the methanol extract [ 177 ].…”

Section: Health-related Bioactive Properties Of Zanthoxylum Speciesmentioning

confidence: 99%

“…In addition, ethyl acetate, chloroform, and methanol extracts of Z. armatum root were evaluated for their ability to prevent paracetamol-mediated hepatic damage in rats and results showed that methanol extract showed the highest hepatoprotective activity, which was related to its high total phenolic content compared to other extracts [ 177 ]. Activity-guided fractionation identified lupeol as the active ingredient responsible for the hepatoprotective effects of the methanol extract [ 177 ]. The hepatoprotective effects of different parts of Z. armatum could be linked to their strong antioxidant activities [ 86 ].…”

Section: Health-related Bioactive Properties Of Zanthoxylum Speciesmentioning

confidence: 99%

Zanthoxylum Species: A Comprehensive Review of Traditional Uses, Phytochemistry, Pharmacological and Nutraceutical Applications

et al. 2021

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Zanthoxylum species (Syn. Fagara species) of the Rutaceae family are widely used in many countries as food and in trado-medicinal practice due to their wide geographical distribution and medicinal properties. Peer reviewed journal articles and ethnobotanical records that reported the traditional knowledge, phytoconstituents, biological activities and toxicological profiles of Z. species with a focus on metabolic and neuronal health were reviewed. It was observed that many of the plant species are used as food ingredients and in treating inflammation, pain, hypertension and brain diseases. Over 500 compounds have been isolated from Z. species, and the biological activities of both the plant extracts and their phytoconstituents, including their mechanisms of action, are discussed. The phytochemicals responsible for the biological activities of some of the species are yet to be identified. Similarly, biological activities of some isolated compounds remain unknown. Taken together, the Z. species extracts and compounds possess promising biological activities and should be further explored as potential sources of new nutraceuticals and drugs.

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Evaluation of Hepatoprotective Activity of Zanthoxylum armatum on Paracetamol-induced Liver Toxicity in Rats

Cited by 14 publications

References 41 publications

Phytochemical Analysis, Antioxidant and Hepatoprotective Activity of Actiniopteris Radiata

Phytochemical Analysis, Antioxidant and Hepatoprotective Activity of Actiniopteris Radiata

An Overview of Genus Zanthoxylum with Special Reference to Its Herbal Significance and Application

Zanthoxylum Species: A Comprehensive Review of Traditional Uses, Phytochemistry, Pharmacological and Nutraceutical Applications

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