Melissa officinalis
(Lamiaceae) was used to treat multiple human afflictions. Literary works demonstrated that it has many biological activities. Today’s research aims to recognise
Melissa officinalis
phyto-derived anti-viral compounds against main protease and spike protein of COVID-19, to gain insight into the molecular interactions. In the current study, 12 molecules taken from
Melissa officinalis
were analysed through docking, which is derived from the PubMed database. Docking experiments were conducted with Autodock tool. AdmetSAR and Data warrior servers were eventually used for drug-like prediction. Our research shows that three phytoconstituents from
Melissa officinalis
, namely, Luteolin-7-glucoside-3′-glucuronide, Melitric acid-A and Quadranoside-III have exhibited better binding affinity and stability with the targets of COVID-19 main protease and spike protein. The identified substances can be further extended for
in vitro
and
in vivo
studies to assess their effectiveness against COVID-19.
This chapter describes the habitat and cultivation of Garcinia species around the world, and the efficacy of the biologically active (i.e. with antibacterial, antifungal, antiviral, antiparasitic, antidiabetic, antiinflammatory, antioxidant and cytotoxic properties, among other activities) chemical constituents of Garcinia species, which have potential applications in the food and drug industries. The chemical structures of some compounds are presented.
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