2010
DOI: 10.3923/rjpharm.2010.60.65
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Reversal of Cadmium Induced Oxidative Stress and its Bio-Accumulation by Culinary Herbs Murraya koenigii and Allium sativum

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Cited by 9 publications
(7 citation statements)
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“…Earlier reports have suggested the involvement of FPN in impeding the metabolic enzymatic systems that are often known to contain sulfhydryl groups and uncoupling of oxidative phosphorylation in the mitochondrial complex [ 16 ]. The process is often thought to result in increased lipid peroxidation, DNA damage, depletion of sulfhydryls, altered calcium homeostasis, hepatic congestion, ischemia, hypoxia and death [ 17 ].…”
Section: Introductionmentioning
confidence: 99%
“…Earlier reports have suggested the involvement of FPN in impeding the metabolic enzymatic systems that are often known to contain sulfhydryl groups and uncoupling of oxidative phosphorylation in the mitochondrial complex [ 16 ]. The process is often thought to result in increased lipid peroxidation, DNA damage, depletion of sulfhydryls, altered calcium homeostasis, hepatic congestion, ischemia, hypoxia and death [ 17 ].…”
Section: Introductionmentioning
confidence: 99%
“…The need to use natural antioxidants has become necessary due to their importance in reducing oxidative stress and many diseases (Kim et al, 2015). The antioxidant effect of these materials was due to their free radical scavenging role in the addition to increasing the level of glutathione and catalase and reducing the level of malondialdehyde (Bharavi et al, 2010). Where Labaque et al (2013) showed that, the administration of thyme at a dose of 80 mg / bird / day led to an improvement in the productive characteristics of the quails subjected to stress.…”
Section: Antioxidant Effect Of Phytogenic Compoundsmentioning
confidence: 99%
“…Moreover Cd displaces of essential metals as zinc and selenium from active binding sites in their requiring enzymes and deactivates this enzymes and Cd replaces calcium in calcium binding proteins causing disruption or cessation of activity which can lead to oxidative stress 87 . Furthermore, Cd depletes GSH and oxidation of protein bound sulfhydryl groups resulting in increased ROS production 88 . Reactions of these ROS with cellular biomolecules have been shown to lead to lipid peroxidation, membrane protein and DNA damage and consequent cellular dysfunction and necrotic cell death 88 .…”
Section: Histopathological Examination Of Testesmentioning
confidence: 99%
“…Furthermore, Cd depletes GSH and oxidation of protein bound sulfhydryl groups resulting in increased ROS production 88 . Reactions of these ROS with cellular biomolecules have been shown to lead to lipid peroxidation, membrane protein and DNA damage and consequent cellular dysfunction and necrotic cell death 88 .…”
Section: Histopathological Examination Of Testesmentioning
confidence: 99%