Liquid and gas micro-calorimeters for (bio)chemical measurements

Herwaarden, A.W. van; Sarro, P.M.; Gardner, Julian W.; Bataillard, P.

doi:10.1016/0924-4247(93)00658-q

Cited by 61 publications

(26 citation statements)

References 2 publications

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“…Previous work in liquid calorimetry can be found in [3][4][5][6][7][8][9][10][11][12]. Wang et al and Lee et al have developed a micro DSC chip with enclosed liquid chambers with a volume of 1 ml and 1.2 ml respectively [11,12].…”

Section: Introductionmentioning

confidence: 99%

Fast differential scanning calorimetry of liquid samples with chips

Splinter¹,

Herwaarden²,

Wetten³

et al. 2015

Thermochimica Acta

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Section: Introductionmentioning

confidence: 99%

Fast differential scanning calorimetry of liquid samples with chips

Splinter¹,

Herwaarden²,

Wetten³

et al. 2015

Thermochimica Acta

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“…A thermovoltage between the hot and cold junctions develops, which is proportional to the temperature difference (in the millikelvin range). The calorimetric sensing process thus includes four principal steps: (1) absorption of the analyte and subsequent partitioning, (2) liberation or abstraction of heat, which causes (3) temperature changes, which are (4) transformed into thermovoltage changes 26,27 . In contrast to the capacitive and gravimetric chemical sensors relying on equilibrium signals, the calorimetric sensor detects only transients, meaning only changes in the analyte concentration 24±27 .…”

mentioning

confidence: 99%

Smart single-chip gas sensor microsystem

Hagleitner

Hierlemann

Lange

et al. 2001

Nature

580

345

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Research activity in chemical gas sensing is currently directed towards the search for highly selective (bio)chemical layer materials, and to the design of arrays consisting of different partially selective sensors that permit subsequent pattern recognition and multi-component analysis. Simultaneous use of various transduction platforms has been demonstrated, and the rapid development of integrated-circuit technology has facilitated the fabrication of planar chemical sensors and sensors based on three-dimensional microelectromechanical systems. Complementary metal-oxide silicon processes have previously been used to develop gas sensors based on metal oxides and acoustic-wave-based sensor devices. Here we combine several of these developments to fabricate a smart single-chip chemical microsensor system that incorporates three different transducers (mass-sensitive, capacitive and calorimetric), all of which rely on sensitive polymeric layers to detect airborne volatile organic compounds. Full integration of the microelectronic and micromechanical components on one chip permits control and monitoring of the sensor functions, and enables on-chip signal amplification and conditioning that notably improves the overall sensor performance. The circuitry also includes analog-to-digital converters, and an on-chip interface to transmit the data to off-chip recording units. We expect that our approach will provide a basis for the further development and optimization of gas microsystems.

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“…The multitransducer system has been described in detail earlier (9,34) so that we only include little information here: It comprises three polymer-coated transducers, a capacitive, a mass-sensitive and a calorimetric transducer along with all necessary front-end and signal conditioning circuitry on a 7 by 7 mm 2 CMOS chip (9,(35)(36)(37).…”

Section: Introductionmentioning

confidence: 99%

The Use of Different Transduction Principles for Qualitative and Quantitative Chiral Gas Analysis

Hierlemann¹,

Kurzawski²,

Schurig³

2009

ECS Trans.

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Different chiral cyclodextrin derivatives, dissolved in a polysiloxane matrix, have been used as enantioselective sensitive coatings on a three-transducer microsystem including a calorimetric, a mass-sensitive and a capacitive chemical sensor. Upon exposure to chiral analytes, such as methyl lactate and methyl-2-chloropropionate, all three transducers showed a distinct chiral discrimination of these analytes. It was shown that the absorption and desorption kinetics of the two enantiomers of, e.g., methyl-2-chloropropionate are sufficiently different to produce sensor signal features that enable an accurate determination of the enantiomeric purity and of the enantiomeric composition of the chiral analyte or mixture under investigation.

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Liquid and gas micro-calorimeters for (bio)chemical measurements

Cited by 61 publications

References 2 publications

Fast differential scanning calorimetry of liquid samples with chips

Fast differential scanning calorimetry of liquid samples with chips

Smart single-chip gas sensor microsystem

The Use of Different Transduction Principles for Qualitative and Quantitative Chiral Gas Analysis

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