Lipotropic Factors

McHenry, E. W.; Patterson, Jean M.

doi:10.1152/physrev.1944.24.1.128

Cited by 71 publications

(14 citation statements)

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“…1 are based on those in Table 1. DISCUSSION The increased deposition of liver lipids which has been reported (McHenry & Patterson, 1944) to occur following the injection of biotin, has been observed in some but not in all of our experiments. This increase is clearly demonstrated by the data in Table 1 (cf.…”

Section: Resultssupporting

confidence: 48%

The influence of biotin upon the relative lipotropic effects of choline and inositol

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Lucas

Patterson

et al. 1946

Biochemical Journal

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IQ46can be sufficiently strong to react with the small number of the more polarizable excited molecules in solution. These, excited molecules are present in extremely small concentration, but they alone are responsible for fluorescence.We thus arrive at the conclusion that, despite apparent discrepancies, the quenching effects of purines are due to the same intermolecular forces as are responsible for their solubilizing effect and the formation of molecular compounds. SUMMARY 1. The fluorescence of polycycic aromatic hydrocarbons in aqueous caffeine solution is quenched by acidification. The quenching is reversible on neutralization. The active quenching agent is the caffeine ion, not the H-ion.2. Other purine bases, such as hypoxanthine, xanthine and N-methylxanthines, have an effect similar to that of caffeine. Uric acids quench even in pure water or aqueous ethanol, and their quenching effect is not appreciably affected by changes in the pH of the medium. A third group of purines, comprising compounds with electronegative substituents other than uric acids, and including adenine and guanine, occupy an intermediate position in that they quench without acidification, but their quenching effect is somewhat intensified in acid solution. Substances without the 4:5-double bond or the double bond adjacent to C. do not quench.3. The quenching effects are strongest in water and decrease in less polar solvents.4. The quenching is due to a reversible photochemical reaction and not to absorption of either primary or secondary radiation.5. The quenching effects were also observed with non-hydrocarbons, such as quinine sulphate, acridine sulphate, quinaldine sulphates, thiochrome, riboflavin, fluorescein. Neutral caffeine solutions sometimes exert a quenching effect, e.g. on riboflavin, and sometimes they cause an intensification of fluorescence, e.g. with thiochrome, mepacrine or eosin.6. The results are discussed, and it is concluded that, despite apparent discrepancies, the quenching effects of purines are due to the same intermolecular forces as are responsible for the solubilizing effect and the formation of molecular compounds.I am greatly indebted to Dr J. Weiss for help with the discussion part of this paper.

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Section: Resultssupporting

confidence: 48%

The influence of biotin upon the relative lipotropic effects of choline and inositol

Best

Lucas

Patterson

et al. 1946

Biochemical Journal

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“…They may give more information than measurements of cholesterol and its fractions, to which attention has been largely confined. This is to be expected from experimental studies of dietary fatty livers and toxic hepatitis, in which it has been found that the formation of a balanced mixture of phospholipids is essential to the proper function of the liver and the orderly metabolism of fat (3).…”

Section: The Concentration Of Lipids In the Serummentioning

confidence: 95%

“…For about 8 months he had been exposed in his occupation to an organic halide preparation. He continued to work for a week after the appearance of jaundice, 3 weeks before admission, but was then forced to desist because of weakness and vomiting which increased steadily. On March 2, blood was noted in the vomitus, and on March 4 he became stuporous.…”

Section: The Concentration Of Lipids In the Serummentioning

confidence: 99%

The Lipids of Serum and Liver in Patients With Hepatic Diseases 1

Man

Kartin²,

Durlacher³

et al. 1945

J. Clin. Invest.

106

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“…Administration of chemicals such as ethanol (1-4), carbon tetrachloride (5-10) , ethionine (11-13), orotic acid (14-16) and so on, or choline deficiency (17 , 18), excess administration of fat or cholesterol (19,20), vitamin imbalance (21), malnutrition due to the admin istration of low protein, high carbohydrate diet (22)(23)(24)(25) , all of which in fact induce the fat infiltration in the liver. Moreover, in view of the complexity of liver lipids and the fact that the liver is very active in lipid metabolism , it would not 1 Following abbreviations are used: be surprising that there are occurrences of many types of fatty liver .…”

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confidence: 99%