Lipoprotein(a) and other lipoproteins in hypothyroid patients before and after thyroid replacement therapy

Becerra, A.; Bellido, David; Luengo, Antonio; Piédrola, G; Luis, Daniel Antonio de

doi:10.1016/s0261-5614(98)80031-9

Cited by 42 publications

(25 citation statements)

References 27 publications

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“…1). Body weight, BMI and serum levels of total cholesterol, LDL-cholesterol and HDL-cholesterol changed significantly, as reported (39). CCA IMT, a valuable indicator of early atherosclerosis and thus a good predictor of cardiovascular events (17 -21), also decreased significantly during 1 year of normalization of thyroid function (Fig.…”

Section: Discussionsupporting

confidence: 71%

“…Although hyperlipidemia is attributed to hypothyroidism (11,39), no significant association is found between changes in each marker and those of serum lipids during L-T 4 treatment ( Table 2). The lack of correlation of changes in TSH, FT 4 and FT 3 with that of vWF suggested that thyroid hormone itself did not regulate serum levels of vWF resulting from endothelial synthesis and/or metabolism of vWF.…”

Section: Discussionmentioning

confidence: 95%

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Change in von Willebrand factor and carotid intima-media thickness in hypothyroid patients with normal thyroid function after levothyroxine replacement therapy

Nagasaki

Inaba

Henmi

et al. 2004

European Journal of Endocrinology

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Objective: This study examined whether levothyroxine (L-T 4 ) replacement might affect serum markers of endothelium injury, including von Willebrand factor (vWF), factor VIII activity and thrombomodulin (TM), during normalization of increased intima-media thickness (IMT) in the common carotid artery (CCA) in hypothyroid patients after L-T 4 replacement therapy. Patients and methods: Thirty-three hypothyroid patients were examined for vWF, factor VIII, TM and CCA IMT before and after 1 year of normalization of thyroid function by L-T 4 replacement. CCA IMT was measured from digitized still images taken during scanning by high-resolution ultrasonography as an indicator of early atherosclerosis. Results: Serum factor VIII and vWF increased significantly during 1 year of normalization of thyroid function (from 122.7^9.4 to 151.3^18.8% (P , 0.05) and from 109.9^9.6 to 135.2^12.4% (P , 0.005) respectively), although these values all fell within the respective normal range. Serum TM, in contrast, did not change appreciably in response to L-T 4 treatment, moving from 2.57^0.15 to 2.74^0.18 ng/ml (P ¼ 0.086). During 1 year of a euthyroid state, all patients showed a significant decrease in CCA IMT (P , 0.0001). Change in serum vWF, but not in factor VIII or TM, showed a positive correlation with that of CCA IMT during L-T 4 replacement therapy. Furthermore, the change in serum vWF was significantly and independently associated with change in CCA IMT (r ¼ 0.490, P ¼ 0.0038).Conclusions: The present study demonstrated that the improvement of CCA IMT during L-T 4 treatment might have the potential to attenuate an elevation of vWF and to attenuate vascular injury by the cardiovascular effects of thyroid hormone in hypothyroid patients. 150 125-131 European Journal of Endocrinology

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 95%

Change in von Willebrand factor and carotid intima-media thickness in hypothyroid patients with normal thyroid function after levothyroxine replacement therapy

Nagasaki

Inaba

Henmi

et al. 2004

European Journal of Endocrinology

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“…In cases of hypothyroidism, how the serum Lp(a) levels are influenced by thyroid hormone remains unknown and contradictory results on the effect of thyroid hormone replacement on serum Lp(a) levels have been reported [6][7][8][9][10][11][12][13]. Although an altered lipid profile is frequently observed in patients with thyroid dysfunction, published data on the relationship between Lp(a) and thyroid status are controversial [14].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Lipoprotein(a) and Thyroid Hormones in Hypothyroid Patients

Kaliaperumal

William

Selvam

et al. 2014

JCDR

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Background and Objective: Changes in plasma lipid con cen trations are well known metabolic consequences of thyroid dysfunction. The alterations are most prominent in hypothyroidism which is typically associated with pronounced hypercholesterolaemia and frequently with moderate hyper triglyceridaemia. In cases of hypothyroidism, how the serum Lp(a) levels are influenced by thyroid hormone remains unknown and contradictory results on the effect of thyroid hormone on serum Lp(a) levels have been reported. There is substantial evidence to suggest that elevated serum Lp(a) levels contribute significantly to the development of CHD. The present study was designed to determine the lipoprotein(a) [Lp(a)], lipid profile and thyroid hormone levels in newly diagnosed hypothyroid patients and to find any correlation that existed between Lp(a) and other parameters.

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“…Unfortunately, no data are available for the decrease in serum OPG levels during treatment for hyperlipidemia or hypertension. Although hypothyroidism induces hyperlipidemia (13), no significant association was found between serum OPG levels and the baseline level of serum lipids or changes in the serum lipid level during L-T4 replacement therapy (Tables 2 and 4), negating the possible involvement of hyperlipidemia-induced vascular injury in the increase in serum OPG levels. Although thyroid hormone causes vascular injury via multiple mechanisms (20, 28 -30), including its effect on the hemodynamic state, no association was found between serum OPG and hemodynamic factors such as mean blood pressure (Tables 2 and 4), systolic and diastolic blood pressure, and pulse rate in the present study.…”

Section: Discussionmentioning

confidence: 90%

“…We recently reported that intima-media thickness (IMT) in the common carotid artery, a good predictor for cardiovascular events (10,11), is increased in hypothyroid patients, and that increased IMT normalized after one year of levothyroxine (L-T4) replacement therapy (12). Accelerated atherosclerosis in hypothyroidism is accounted for by multiple mechanisms, including hyperlipidemia (13), hypercoagulable state (14), impaired endothelium-dependent vasodilation (15) and obesity (16). However, since there is no data on serum OPG levels in hypothyroidism, it is of importance to assess the possible involvement of OPG in the increased arterial thickening in hypothyroidism.…”

Section: Introductionmentioning

confidence: 99%

Increased levels of serum osteoprotegerin in hypothyroid patients and its normalization with restoration of normal thyroid function

Nagasaki¹,

Inaba²,

Jono³

et al. 2005

eur j endocrinol

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Hypothyroidism is associated with increased morbidity from cardiovascular disease, and an increase in serum osteoprotegerin (OPG) has recently been reported to be associated with the severity of coronary heart disease and cardiovascular mortality. The present study was designed to examine whether hypothyroidism causes an increase in serum OPG, and to determine whether levothyroxine (L-T4) replacement therapy might suppress serum OPG levels in hypothyroid patients. Fifty-three hypothyroid patients with chronic thyroiditis and age-and sex-matched normal control subjects were examined for the levels of serum OPG and plasma von Willebrand factor (vWF), a vascular injury marker. Thirty-seven of the hypothyroid patients were further monitored for changes in these markers during 1 year in a euthyroid state induced by L-T4 replacement therapy. Baseline OPG was significantly higher in hypothyroid patients than in normal controls (4.51^0.50 vs 3.72^0.23 pmol/l (mean^S.E.); P ¼ 0.0182). In multivariate analysis, baseline OPG was significantly associated with baseline levels of TSH (r ¼ 0.280, P ¼ 0.0162) and vWF (r ¼ 0.626, P , 0.0001). During one year of L-T4 replacement therapy, hypothyroid patients showed a significant decrease in OPG levels from 4.35^0.51 to 3.48^0.26 pmol/l (P ¼ 0.0166), a level comparable to normal controls. The change in serum OPG levels during L-T4 replacement therapy was significantly and independently associated in a negative fashion with baseline vWF (r ¼ 2 0.503, P ¼ 0.0014). This study suggested that the severity of hypothyroidism and vascular injury might have important independent roles in increasing the serum OPG level in hypothyroid patients. Furthermore, it was demonstrated that a sustained euthyroid state might have the potential to decrease the serum OPG level in hypothyroid patients and that the degree of vascular injury in the hypothyroid state is independently associated with a decrease in serum OPG during a 1-year normalization of thyroid function.

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Lipoprotein(a) and other lipoproteins in hypothyroid patients before and after thyroid replacement therapy

Cited by 42 publications

References 27 publications

Change in von Willebrand factor and carotid intima-media thickness in hypothyroid patients with normal thyroid function after levothyroxine replacement therapy

Change in von Willebrand factor and carotid intima-media thickness in hypothyroid patients with normal thyroid function after levothyroxine replacement therapy

Relationship between Lipoprotein(a) and Thyroid Hormones in Hypothyroid Patients

Increased levels of serum osteoprotegerin in hypothyroid patients and its normalization with restoration of normal thyroid function

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