Change in von Willebrand factor and carotid intima-media thickness in hypothyroid patients with normal thyroid function after levothyroxine replacement therapy

Nagasaki, Toshiki; Inaba, Masaaki; Henmi, Yasuko; Kumeda, Yasuro; Ueda, Misako; Tahara, Hideki; Ishimura, Eiji; Onoda, Naovoshi; Ishikawa, Tetsuro; Nishizawà, Yoshiki

doi:10.1530/eje.0.1500125

Cited by 31 publications

(26 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These data were in good agreement with a previous report demonstrating that serum osteoprotegerin levels correlate with intima-media thickness in the carotid arteries in healthy postmenopausal women (26). Furthermore, we have observed that the reduction of intima-media thickness in the common carotid artery might have the potential to attenuate thyroid hormone-induced vascular injury, as reflected by an attenuation of the increased response of plasma vWF levels during L-T4 replacement therapy in hypothyroid patients (21).…”

Section: Discussionsupporting

confidence: 93%

Increased levels of serum osteoprotegerin in hypothyroid patients and its normalization with restoration of normal thyroid function

Nagasaki¹,

Inaba²,

Jono³

et al. 2005

eur j endocrinol

View full text Add to dashboard Cite

Hypothyroidism is associated with increased morbidity from cardiovascular disease, and an increase in serum osteoprotegerin (OPG) has recently been reported to be associated with the severity of coronary heart disease and cardiovascular mortality. The present study was designed to examine whether hypothyroidism causes an increase in serum OPG, and to determine whether levothyroxine (L-T4) replacement therapy might suppress serum OPG levels in hypothyroid patients. Fifty-three hypothyroid patients with chronic thyroiditis and age-and sex-matched normal control subjects were examined for the levels of serum OPG and plasma von Willebrand factor (vWF), a vascular injury marker. Thirty-seven of the hypothyroid patients were further monitored for changes in these markers during 1 year in a euthyroid state induced by L-T4 replacement therapy. Baseline OPG was significantly higher in hypothyroid patients than in normal controls (4.51^0.50 vs 3.72^0.23 pmol/l (mean^S.E.); P ¼ 0.0182). In multivariate analysis, baseline OPG was significantly associated with baseline levels of TSH (r ¼ 0.280, P ¼ 0.0162) and vWF (r ¼ 0.626, P , 0.0001). During one year of L-T4 replacement therapy, hypothyroid patients showed a significant decrease in OPG levels from 4.35^0.51 to 3.48^0.26 pmol/l (P ¼ 0.0166), a level comparable to normal controls. The change in serum OPG levels during L-T4 replacement therapy was significantly and independently associated in a negative fashion with baseline vWF (r ¼ 2 0.503, P ¼ 0.0014). This study suggested that the severity of hypothyroidism and vascular injury might have important independent roles in increasing the serum OPG level in hypothyroid patients. Furthermore, it was demonstrated that a sustained euthyroid state might have the potential to decrease the serum OPG level in hypothyroid patients and that the degree of vascular injury in the hypothyroid state is independently associated with a decrease in serum OPG during a 1-year normalization of thyroid function.

show abstract

Section: Discussionsupporting

confidence: 93%

Increased levels of serum osteoprotegerin in hypothyroid patients and its normalization with restoration of normal thyroid function

Nagasaki¹,

Inaba²,

Jono³

et al. 2005

eur j endocrinol

View full text Add to dashboard Cite

show abstract

“…C-IMT is larger in overt hypothyroidism subjects compared with euthyroidism subjects, and it decreases after levothyroxine replacement 14,15) . In a study by Monzani et al 16) , subjects with subclinical hypothyroidism had significantly higher mean C-IMT than euthyroidism controls.…”

Section: Introductionmentioning

confidence: 98%

Free Triiodothyronine Concentrations are Inversely Associated with Elevated Carotid Intima-Media Thickness in Middle-Aged and Elderly Chinese Population

Zhou

Zhao

Wang

et al. 2016

JAT

View full text Add to dashboard Cite

“…Moreover, cardiovascular abnormalities, such as left ventricular diastolic impairment, increase of carotid intima-media thickness (IMT), and endothelial dysfunction, have also been reported in patients with subclinical hypothyroidism (SH) (4)(5)(6)(7). In this regard, two recent meta-analyses found that SH is associated with an increased risk of coronary heart disease (8,9), while therapeutic trials with levothyroxine (L-T 4 ) treatment in patients with SH showed a beneficial effect on both functional and structural atherosclerotic markers (10)(11)(12)(13)(14). All the determinants of cardiovascular risk in patients with thyroid function abnormalities are not fully understood, even if hypercholesterolemia and a direct effect of thyroid hormones on arterial wall are certainly involved (1).…”

Section: Introductionmentioning

confidence: 99%

Effects of long-term l-thyroxine treatment on endothelial function and arterial distensibility in young adults with congenital hypothyroidism

Oliviero

Cittadini²,

Bosso³

et al. 2010

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Patients with congenital hypothyroidism (CH) display subclinical abnormalities of the cardiovascular system that are related to unphysiological fluctuations of TSH levels and occur despite careful replacement therapy. Design: The aim of the present case-control study was to evaluate the effects of long-term levothyroxine (L-T 4 ) replacement therapy on the vascular district in CH patients by assessing endothelial function with flow-mediated dilation (FMD) and brachial artery distensibility with the measurement of the coefficient of distensibility (DC). Methods: Thirty-two young adults with CH aged 18.9G0.2 years and 32 age-and sex-matched controls underwent brachial Doppler ultrasound examination to measure FMD and DC at the time of the study. Hypothyroidism was diagnosed by neonatal screening, and L-T 4 treatment was initiated within the first month of life. Results: Compared to healthy controls, CH patients had significantly reduced brachial artery reactivity with lower FMD values (8.9G5.7 vs 14.1G5.1% PZ0.003) and decreased vascular distensibility (24.6G1.6 vs 27.3G3 kPa K1 !10 K3 , P!0.0002). Linear regression analysis revealed that both total and pubertal mean TSH and number of episodes of undertreatment were independent determinants of FMD and DC. Pubertal mean TSH was the best predictor of both FMD and DC (rZ0.81 and rZ0.87 respectively, P!0.001). Conclusions: Young adults with CH treated with long-term L-T 4 replacement therapy may have significant impairment of both FMD and DC. Our data suggest that high TSH levels, inadequately corrected by L-T 4 replacement therapy in CH patients especially during puberty, can exert significant effects on the elastic and functional vessel properties.

show abstract

Change in von Willebrand factor and carotid intima-media thickness in hypothyroid patients with normal thyroid function after levothyroxine replacement therapy

Cited by 31 publications

References 39 publications

Increased levels of serum osteoprotegerin in hypothyroid patients and its normalization with restoration of normal thyroid function

Increased levels of serum osteoprotegerin in hypothyroid patients and its normalization with restoration of normal thyroid function

Free Triiodothyronine Concentrations are Inversely Associated with Elevated Carotid Intima-Media Thickness in Middle-Aged and Elderly Chinese Population

Effects of long-term l-thyroxine treatment on endothelial function and arterial distensibility in young adults with congenital hypothyroidism

Contact Info

Product

Resources

About