Relationship between Lipoprotein(a) and Thyroid Hormones in Hypothyroid Patients

Abstract

Background and Objective: Changes in plasma lipid con cen trations are well known metabolic consequences of thyroid dysfunction. The alterations are most prominent in hypothyroidism which is typically associated with pronounced hypercholesterolaemia and frequently with moderate hyper triglyceridaemia. In cases of hypothyroidism, how the serum Lp(a) levels are influenced by thyroid hormone remains unknown and contradictory results on the effect of thyroid hormone on serum Lp(a) levels have been reported. There is substantial evidence to suggest that elevated serum Lp(a) levels contribute significantly to the development of CHD. The present study was designed to determine the lipoprotein(a) [Lp(a)], lipid profile and thyroid hormone levels in newly diagnosed hypothyroid patients and to find any correlation that existed between Lp(a) and other parameters.

Clinical and laboratory characteristics of patients with thyroid diseases with and without alanine aminotransferase levels above the upper tertile – Cross-sectional analytical study

“…With respect to the parameters of age (20,21) gender (22), and etiology of thyroid disease (23,24), the present study sample is consistent with previous studies of thyroid disease. The average age reported in indivi duals Figure 1.…”

“…In a separate study, Kaliaperumal and cols. (21) found that patients with untreated hypothyroidism had a mean cholesterol level (232.12 ± 5.12 mg/dL) significantly higher than the control group (169.65 ± 2.59 mg/dL). A third study showed that individuals with TSH levels < 0.1 mIU/ml had a mean cholesterol level of 181.70 mg/dL, whereas individuals with TSH levels > 10 mIU/ml had a mean cholesterol level of 209.15 mg/dL (15).…”

“…Study patients present a positive correlation between total cholesterol levels and ALT levels (r = 0.213; p = 0.042). with thyroid disease is 41-50 years (20,21), and the prevalence of hypothyroidism increases with increasing age of the population studied (25). Among our patients, 71% had Hashimoto's thyroiditis as the etiology of thyroid disease, which corroborates findings in the literature that this thyroiditis ranks as the leading cause of hypothyroidism (23,24).…”

Lipid Complications after Hematopoietic Stem Cell Transplantation (HSCT) in Pediatric Patients

“…Therefore, the complications with the hormones secreting organ affect the fatty tissue and steroidogenic tissues. Due to the fact that lipid metabolism remains the most effective energy-supplying source for the organism, even slight alternations in thyroid hormones levels severely affect the plasma lipoproteins [26,[28][29][30]. The patients who supplied the thyroid hormones exhibited lower LDL and higher triglycerides levels comparing to the non-treated group.…”

Вікові Особливості Жирнокислотного Складу Ліпідів Сироватки Крові Щурів З Ожирінням При Впливі Йоду

“…There is evidence that a high level of saturated fatty acids leads to an increase in proinflammatory cytokines, activates Toll-like receptors and influences the development of the oxygenase metabolism of polyene FA [8]. M. Peppa and other researchers have investigated that in half of patients with hypothyroidism, a lipid metabolism disorder is observed [2,9,10].…”