Lipid Profile Pattern in Type 2 Diabetes Mellitus Patients

Sultana, Most Sarmin; Akhter, Yasmin; Parvin, Mimi; Alam, Mahbub Ul; Naznin, Lubna; Wahab, Abdul

doi:10.3329/jafmc.v14i2.45903

Cited by 5 publications

(5 citation statements)

References 3 publications

(4 reference statements)

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“…Although Goel S et al 1 reported that the lipid profile abnormalities were among 83% of the diabetes patients and these findings of lipid profile abnormalities were higher as compared to this study. In another study by Sultana MS et al 16 also found higher frequency of lipid profile abnormalities 94% amongst 300 individuals having type II diabetes who participated in their study.…”

Section: Discussionmentioning

confidence: 72%

“…Consistently, Javed RA et al 15 also reported that the occurrence of dyslipidemia was statistically insignificant according to gender. In the study by Sultana MS et al 16 also observed that there was not significant difference in serum TC, TG and LDL-C according to gender (p->0.05) while HDL was statistically (p-<0.05). Although Goel S et al 1 reported that there were noticeable disparities between the sexes in the prevalence of lipid abnormalities in several aspects of the parameters of lipids, while with the exception of HDL, they did not have a statistically significant association.…”

Section: Discussionmentioning

confidence: 87%

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Lipid Profile Abnormalities among Patients with Diabetes Mellitus Type II, Presented at Tertiary Care Hospital

Memon¹,

Rani²,

Rajkumar³

et al. 2022

PJMHS

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Objective: To determine the lipid profile abnormalities among diabetes patients presented at tertiary care Hospital. Methods: This cross-sectionals study was done at medicine out patient’s department (OPD) at Muhammad Medical College Mirpur-Khas, from September 2020 to September 2021. Patients of type II diabetes mellitus, presented at medicine OPD, aged more than 40 years, diabetes duration more than three years and both genders were included. A five ml blood sample was obtained in fasting from each case and sent to the Hospital laboratory to assess the HbA1c and lipid profile. All the data was collected via a structured study proforma, and the analysis was done using SPSS version 20. RESULTS: In this study, 67 known diabetic patients were studied to observe the frequency of lipid profile abnormalities. Patient’s mean age was 51.64+10.32 years, mean BMI was 25.20+3.23 kg/m2 and mean Hba1c was 7.84+2.94%. Males were in majority 61.2% and females were 38.8%. Out of all 56.7% patients had lipid profile abnormalities. There was a positive correlation between hba1c and triglyceride level and a significant positive correlation between hba1c and total cholesterol level (r = 0.431, p = 0.001). Frequency of lipid profile abnormalities was statistically insignificant according to gender and duration of disease (p=>0.05). Conclusion: Lipid profile abnormalities were observed to be highly frequent among patients with type II diabetes mellitus. The early identification and treatment of dyslipidemia in individuals with DM seems to be a significant aspect of lowering the risk of DM-related morbidity and mortality. Keywords: Diabetes type II, lipid profile, Hba1c

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 87%

Lipid Profile Abnormalities among Patients with Diabetes Mellitus Type II, Presented at Tertiary Care Hospital

Memon¹,

Rani²,

Rajkumar³

et al. 2022

PJMHS

View full text Add to dashboard Cite

show abstract

“…Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia caused by absolute or relative deficiency of insulin. 1 Diabetes more common worldwide according to this data in the year 2017, 463 million people had diabetes worldwide, the rate of 8.8% among adults, while type 2 diabetes make 90% of cases this data show that the type 2 was very rare than type1 diabetes. Another study shows that the number of patients with diabetes mellitus globally has four times as many in the past three decades.…”

Section: Introductionmentioning

confidence: 73%

Atherogenic index of plasma as a biomarker of atherogenecity in type 2 diabetes mellitus in Erbil city

Yousif

Ali

2023

Zanco J Med Sci

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Background and objective: Atherogenic index of plasma (AIP) is a mathematical method logarithmically ratio between concentrations of triglycerides to HDL-cholesterol, AIP= Log (TG/HDL), so AIP increase with increase triglycerides and reversible with HDL level. The aim of this study is to evaluation the AIP as a stronger biomarker of atherosclerosis among type 2 diabetes mellitus (DM). Methods: This was a cross sectional-study contacted. A total of 65 patients of type 2 diabetic patient group from Laila Qasim Center for Diabetes in Erbil City collection of blood samples from 65 patients of type 2 diabetic patient group from Laila Qasim Center for Diabetes in Erbil City, compared with 50 healthy volunteers (control group). Blood samples were collected into serum separation tube (gel tube) and (K3EDTA) tube, allowed gel tube to clot at room temperature for 5 minutes then centrifuged at 4000 round per minute (rpm). The separated serum was used immediately for biochemical tests and all the laboratory investigation analysis were carried out from 2nd January to 2nd August 2021. Results: The results of this study found that the level of serum glucose, HbA1C, albumin, CRP, and AIP in diabetics were significantly higher than healthy group, while decreasing S. HDL in diabetic patients compare with healthy individuals. Conclusion: The study detected high level of AIP in type 2 DM patients. Accordingly, patients with type 2 DM should be followed up with regular dietary lipid intake, take lipid lowering drugs, with exercise in order to diminish AIP.

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“…There is a relationship between lipid profile and the progression of type 2 diabetes mellitus [18]. The study on Diabetic patients found that high levels of total cholesterol (TC), triglycerides(TG), and Low-Density Lipoprotein-Cholesterol (LDL-C) were found in 47.3%, 76.7%, and 41.3% of patients respectively [19].…”

Section: Triacylglycerol/triglyceride Analysismentioning

confidence: 99%

Studi of In Vivo Antidiabetic Activity of Namnam Leaves (Cynometra cauliflora) Extract in Sprague Dawley Rat

Sumarlin

Suprayogi

Rahminiwati

et al. 2023

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Various treatments for Type 2 Diabetes Mellitus (T2DM) aim to alleviate hyperglycemia. Although natural products have been extensively utilized, their mechanism of action and efficacy as antidiabetic agents, particularly for T2DM, has not been extensively assessed in vivo. In this research, the leaves of the Namnam (Cynometra cauliflora) were extracted and tested for their activity as an antidiabetic agent. Sprague Dawley rats aged 3.5-4 months, weighing 200-250 g, were used as the experimental model, with a total of 30 individuals. The rats were induced with a high-fat diet and 30% sucrose until their blood glucose concentration reached ≥ 120 mg/dL. Subsequently, the rats were divided into four groups (groups 1, 2, 3, and 4). Over 21 days, changes in blood glucose, triacylglycerol, glycogen, and blood plasma insulin levels were assessed. The results demonstrated that the methanol extract of Namnam leaves (NLME) effectively reduced blood glucose levels by 23-34%, decreased plasma triglyceride levels by 13-30%, and increased liver glycogen levels by 68-96% compared to the control group (Diabetes). Among all the parameters assessed, NLME exhibited similar performance to metformin, a commonly prescribed diabetes medication (p<0.05). Furthermore, the study revealed that NLME exerted antidiabetic effects, particularly for T2DM, by promoting liver glycogen formation, enhancing insulin secretion control, facilitating glucose absorption by muscles, and restricting fat metabolism in the blood

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Lipid Profile Pattern in Type 2 Diabetes Mellitus Patients

Cited by 5 publications

References 3 publications

Lipid Profile Abnormalities among Patients with Diabetes Mellitus Type II, Presented at Tertiary Care Hospital

Lipid Profile Abnormalities among Patients with Diabetes Mellitus Type II, Presented at Tertiary Care Hospital

Atherogenic index of plasma as a biomarker of atherogenecity in type 2 diabetes mellitus in Erbil city

Studi of In Vivo Antidiabetic Activity of Namnam Leaves (Cynometra cauliflora) Extract in Sprague Dawley Rat

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