Linfossarcoma intracerebral em bovino

Fighera, Rafael A.; Barros, Claudio S.L.

doi:10.1590/s0103-84782004000300046

Cited by 4 publications

(3 citation statements)

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“…Vertebral bone infiltration by lymphoma was not observed in any of the cases; such infiltration is rare and is observed mainly in young cattle with the sporadic form (Theilen & Dungworth 1965, Bundza et al 1980, Oliver-Espinosa et al 1994. Brain involvement in cases of bovine lymphoma may occur; however, it is considered uncommon (Sweeney et al 1986, Sherman 1987, Fighera & Barros 2004, Braun et al 2005, Tawfeeq et al 2012, and it was not observed in the present study. The pathogenesis of extradural lymphoma remains uncertain.…”

Section: Discussioncontrasting

confidence: 56%

Clinical and pathological aspects of bovine lymphoma affecting the spinal cord

et al. 2019

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Clinical and pathological features of bovine lymphoma involving the spinal cord were evaluated through a retrospective study of the necropsy database from 2005 to 2017. Thirty-four cases of bovine lymphoma were found, 24 of which had central nervous system involvement restricted to the spinal cord. All cattle were Holstein cows 2.5-12 years-old (median age, six years-old). The clinical course was 7-21 days, and the main neurological sign was pelvic limb paresis (81.8%). The lymphoma often affected the spinal cord in a multifocal manner. Lumbar segments were the mostly affected sites (23/24), followed by the sacral segments and cauda equina (20/24), cervical (5/24) and thoracic (5/24) segments. Tumors were in the epidural space, peripheral to the pachymeninges (extradural) and between layers of adipose tissue. In addition, two cases had progressive hemorrhagic myelomalacia. Further organs affected included the lymph nodes (100%), abomasum (79.2%), heart (75%) and kidneys (45.8%). Microscopically, all lymphomas had a diffuse pattern, with no meningeal or medullar infiltration. According to the REAL/WHO classification, all these neoplasms were mature B-cell lymphomas. Diffuse large B-cell lymphoma (DLBCL) was observed in 95.8% (23/24) of the cases. The following subtypes were observed in the DLBCL group in descending order: immunoblastic (60.9%, 14/23), centroblastic (26.1%, 6/23), anaplastic (8.7%, 2/23) and T-cell rich (4.3%, 1/23).

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Section: Discussioncontrasting

confidence: 56%

Clinical and pathological aspects of bovine lymphoma affecting the spinal cord

et al. 2019

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“…Outros órgãos envolvidos na forma multicêntrica do adulto incluem coração, abomaso, rim, intestinos, tecidos retrobulbares do olho, útero, tecidos epidurais da medula espinhal e, raramente, o cérebro (Fighera & Barros 2004.). Neste estudo, além dos linfonodos, coração (Fig.1C) e abomaso (Fig.1B), foram frequentemente afetados.…”

Section: Linfomaunclassified

Tumores em bovinos encontrados em abatedouros frigoríficos

Tessele

Barros

2016

Pesq. Vet. Bras.

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ABSTRACT. - In a survey for lesions in cattle in abattoirs from January 2011 to July 2014, 544 lesions were found, of which 65 were neoplasms. Forty two percent of those were of mesenchymal origin; 37% were epithelial; 14,5% were neural crest derivatives; 5% were sex chord derived tumors and 1.5 was from the peripheral nervous system. The most common tumor found was lymphoma (28% of all tumors), most of them as part of the enzootic leukosis complex. Squamous cell carcinoma was the second most frequent tumor (15% of all tumors). Consideration is made on the frequency of these tumors and the importance of the differential diagnosis at gross examination at the slaughterhouse among them and other important lesions, including tuberculous granulomatous lesions. There was a significance occurrence (13% of all tumors) of the adrenal tumor, pheocromocytoma. Papillomatosis represented only 3% of all tumors; as those are common benign tumors in cattle; their low numbers in this review could be explained by the fact that these are not tumors usually detected in the postmortem examination (after the hide was stripped from the carcass) which was mostly the case of this study, but rather by antemortem inspection. Less common tumors found (each accounting for 1.5 to 3% of all tumors) included granulosa cell tumor, gastrointestinal stromal tumor, hemangiosarcoma, hepatic tumors, interdigital fibroma, lipoma, liposarcoma, mammary adenocarcinoma, melanocytic tumors, mesothelioma, mixed apocrine adenocarcinoma of the tail, neurofibroma, renal cell carcinoma, primary pulmonary tumors, uterine adenocarcinoma, and uterine leiomyoma. It is intended that the results of this survey would be helpful in the identification of lesions at in the official meat inspection at the slaughterhouses.

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“…The clinical presentation observed in this case points to the oral cavity as the primary. Neurological signs, such as head pressing, has been described in bovine lymphoma due to nasal cavity tumors invading the brain [6] or arising there [7]. No neurological sign was observed in the cow of this report.…”

Section: Discussionmentioning

confidence: 53%

Peripheral T-Cell Lymphoma in the Oral Cavity of a Cow

Guizelini

Pupin

Barros

et al. 2019

Acta Scientiae. Vet.

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Background: Squamous cell carcinomas and lymphomas are the most prevalent neoplasms in cattle, the latter usually being attributed to infection by bovine leukemia virus (BLV). Neoplasms of the oral cavity are sporadic in cattle, with but a single case of lymphoma involving this anatomic site in a bovine reported to date. This paper reports a case of lymphoma involving the oral cavity of a dairy cow. The clinical and pathological aspects of the tumor are described and discussed.Case: A 39-month-old Holstein-Friesian cow was presented with weight loss and a tumorous growth in the left masseter region, tearing in the left eye, and mild ipsilateral exophthalmos. Treatment with antibiotics was unsuccessful. The tumor growth was 16 x 11 cm, with a soft center and firm periphery, multilobulated, with white intercalated with black and friable areas from which a fetid odor emanated. The cut surface was predominantly white-yellow. A cross-section of the head, caudal to the second molar, revealed a mass infiltrating and almost completely obliterating the left nasal cavity, destroying the frontal sinus, the ventral conchae, and the middle and ventral meatus, and compressing the common meatus. The tracheobronchial, mediastinal, and internal iliac lymph nodes were enlarged and masses with similar characteristics to those in the oral cavity replace their parenchyma. Microscopically, the mass consisted of large neoplastic lymphocytes arranged in a non-encapsulated and infiltrative mantle and supported by scarce fibrovascular tissue. The cytoplasm of neoplastic cells was scarce and had distinct boundaries; the nuclei were round or oval, the chromatin was finely granulated, and the prominent nucleolus had occasionally multiplied. Nuclear pleomorphism was marked and there were, on average, five mitotic figures per microscopic field of 400x. Similar neoplastic cells obliterated the normal structure of the tracheobronchial, mediastinal, and internal iliac lymph nodes. In the immunohistochemical examination, labeling was diffuse and moderate in the cytoplasm of neoplastic cells when a CD3 antibody was used, and negative when antibodies to CD79α, cytokeratin, and vimentin were used. Due to its characteristic markings in the immunohistochemistry panel, the neoplasm was classified as an unspecified peripheral T-cell lymphoma.Discussion: The diagnosis of lymphoma was based on clinical signs and gross and histopathological findings, and was confirmed by immunohistochemistry. Lymphomas in cattle are common in several organs as part of enzootic bovine leukosis, a virus-induced type of B-cell lymphoma. However, lymphomas are rare in the oral cavity. The clinical presentation observed in this case points to the upper alimentary tract as the primary site of the neoplasm once clinical respiratory signs were not observed in the cow. The neoplasm cells described here presented a T-cell profile in immunohistochemistry panel, suggesting that the tumor should be included in the sporadic form of bovine leukosis since B-cells are the cellular population in cases of enzootic bovine leukosis. However, since the diagnosis of enzootic leukosis was not definitively excluded in this case, the cause of the neoplasia cannot be conclusively determined. It is concluded that, although rare, lymphomas may indeed occur in the bovine oral cavity and should be included in the differentials list for tumoral growth in the lateral region of the bovine face.

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Linfossarcoma intracerebral em bovino

Abstract: Intracerebral lymphosarcoma in a cow RESUMO

Cited by 4 publications

References 10 publications

Clinical and pathological aspects of bovine lymphoma affecting the spinal cord

Clinical and pathological aspects of bovine lymphoma affecting the spinal cord

Tumores em bovinos encontrados em abatedouros frigoríficos

Peripheral T-Cell Lymphoma in the Oral Cavity of a Cow

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