Lignocaine: Its effects on wound healing

Abstract

In the light of clinical observations that local anaesthetic impairs wound healing, the effect of lignocaine at various concentrations, with and without adrenaline, on the tensile strength of skin wounds in rats 3, 5 and 7 days after operation was studied. Lignocaine had an adverse effect on wound healing at 5 and 7 days, perhaps due partly to the destructive effect of the intra- and subcutaneous injection, but certainly due also to the lignocaine itself. Adrenaline potentiated this effect. It was concluded that it is better to use dilute solutions of lignocaine, preferably without adrenaline, for local anaesthesia.

Comparação dos efeitos da infiltração com bupivacaína, lidocaína e tramadol na cicatrização de feridas em ratos

“…While our study found results similar to previous studies on the effects of bupivacaine and lidocaine on wound healing [30][31][32][33][34][35][36][37][38][39][40][41] , no significant difference was found between tramadol and the control group. The antibacterial properties of local anesthetics and other agents used in wound infiltration are important.…”

“…Past studies have found that the concentration of local anesthetic affects wound healing while high concentrations of local anesthetic delay healing 30,39,40 . While doses inferior to 100 mcg.mL -1 of lidocaine had no effect on healing, in a study of corneal epithelial cells, doses above 250 mcg.mL -1 delayed epithelial healing in a dose-dependent fashion 41 .…”

The Effect Of A Hemostatic Agent (fastact) To Wound And Tissue Repair In A Rat Model

“…[14][15][16] Eroglu et al, [17] evaluated the effects of lidocaine/prilocaine cream on wound healing. They concluded that lidocaine/prilocaine cream as topical anesthetic agent had no adverse effect on an incisional wound model.…”

?Alternative? effects of local anesthetic agents

“…In der Literatur existieren diesbezüg-lich widersprüchliche Meinungen: Die meisten in-vitro-Studien berichteten über negative Effekte auf die Wundheilung,bezogen auf die beobachtete Reduktion der Mukopolysaccharid-und Kollagensynthese [13,66].Einige andere Lokalanästhetika-effekte könnten die Wundheilung ebenfalls beeinflussen: Lokalanästhetika inhibieren z.B.die Signalübertragung von Lysophosphatidylsäure (LPA), einer Substanz, die sehr wahrscheinlich in die Wundheilung involviert ist [16].Sie greifen in den Sauerstoffmetabolismus von Leukozyten ein (maßgeblich für die lokale Reparatur eines Gewebeschadens in einem Mausmodell [20]). Tetracain (0,001-bis 0,25%ig) induziert eine konzentrationsund zeitabhängige Reduktion der Lebensfähigkeit kultivierter humaner Keratozyten [65].…”