The Effect Of A Hemostatic Agent (fastact) To Wound And Tissue Repair In A Rat Model

Abstract

Objectives:The purpose of this study was to test the hypothesis that the hemostatic agent (FastAct) exerts favourable effect on wound healing and tissue repair alone and along with prilocaine hydrochloride in vivo. Wound healing process is a complex procedure that starts with bleeding and hemostasis. Comprising of bovine factor proteins II, VII, IX and X, FastAct is used as a catalyst in the clot formation process to activate factors II, V, VIII and XIII. Materials and Methods:The study was performed on 21 Wistar male rats. Cutaneous incisions at the length of 4 cm. were made on the dorsal side of all animals. In seven, FastAct was applied alone between the wound edges and, in the other seven, FastAct was applied along with prilocaine. The wounds were sutured by resorbable suture material. Results:The specimens were obtained on the seventh day. Wound breaking strength test was performed before histological examination. In the FastAct group the epithelialization and the closure of the wound edge were better than the other groups. The results of the breaking strength test showed that the results were best in FastAct group. Conclusion:It's concluded that FastAct accomplished hemostasis, facilitated wound healing in accordance with natural processes.

Histopathological Effects of Algan Hemostatic Agent (AHA) in Liver Injury Model in Rats

“…[7] Agents such as chitosan, ankaferd, coolclot, fastact, zeolite or algan hemostatic agent (AHA) are among them and they preferred in coagulopathic patients to reduce bleeding and the risk of infection. [8][9][10][11][12] Algan hemostatic agent liquid is a class III hemostatic agent (Certificate number: XXXX) that is derived from the standardized mixture of six different plants. Each of the plants that make up the AHA has a content that provides hemostasis in combinations.…”