In our study, we found bupivacaine and lidocaine reduced the collagen production, wound breaking strength, and caused significantly high scores for edema, vascularity, and inflammation when compared to the control group. There was no significant difference between the control and the tramadol group. Results of this experimental preliminary study on rats support the idea that tramadol can be used for wound infiltration anesthesia without adverse effect on the surgical healing process. These results need to be verified in humans.

Summary: Hancı V, Hakimoğlu S, Özaçmak H, Bektaş S, Özaçmak HS, Özdamar ŞO, Yurtlu S, Turan IÖ -Comparison of the Effects of Bupivacaine, Lidocaine, and Tramadol Infiltration on Wound Healing in Rats. Background and objectives:The aim of this study was to investigate the effects of saline solution, bupivacaine, lidocaine and tramadol infiltration on wound healing in rats.