Light and electron microscopic observations on a ganglioneuroma

Bender, Bruce L.; Ghatak, Nitya R.

doi:10.1007/bf01273259

Cited by 31 publications

(5 citation statements)

References 10 publications

(3 reference statements)

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“…Similar filamentous inclusions have been reported in aged DRGN of Wistar rats (Koistinaho et al, 1991), in developing human DRGN treated with intracellular tangles seen in ganglioneuromas (Bender and Ghatak, 1978).…”

Section: Discussionmentioning

confidence: 71%

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Retardation of neuritic outgrowth and cytoskeletal changes accompany acetylcholinesterase inhibitor treatment in cultured rat dorsal root ganglion neurons

Dupree

Bigbee

1994

J of Neuroscience Research

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Over the past two decades acetylcholinesterase (AChE) has been shown to be present in numerous non-cholinergic and non-cholinoceptive tissues. Interestingly, transient expression of AChE in developing nervous tissue corresponds temporally with neuronal migration and neuritic outgrowth. This observation has led our laboratory to investigate a possible novel, non-cholinergic role for AChE in the development of the nervous system. In a previous study, we demonstrated that the activity of AChE in cultured dorsal root ganglion neurons (DRGN) can be modulated by the substratum. In our current study, we have examined the effects of AChE inhibitor treatment on neuritic outgrowth on the highly permissive substratum Matrigel and the less permissive substratum Collagen Type I. DRGN received serial dilutions of the AChE-specific inhibitor 1,5-bis-(4-allyldimethylammoniumphenyl) pentan-3-one dibromide (BW284c51) ranging from 10(-4) to 10(-7) M. Results showed that neuritic outgrowth was significantly reduced in DRGN grown on Matrigel at 10(-5) and 10(-4) M BW284c51, while outgrowth on Collagen Type I was significantly reduced at 10(-6), 10(-5), and 10(-4) M concentrations of BW284c51. Inhibitor treatment did not affect cell survival and neuritic outgrowth from BW284c51-treated cells recovered to control levels after removal of the inhibitor from the medium. In addition, massive spiraling accumulations of 10 nm filaments were observed in the cell bodies of treated neurons, which resemble neurofibrillary inclusions observed in neuropathological diseases such as Pick's disease. This study demonstrates that AChE inhibitor treatment retards neuritic outgrowth and neuronal migration of cultured DRGN which is accompanied by cytoskeletal abnormalities in the cell body.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 71%

“…X 6,000 (A), X 4,800 (B), and X 21,600 (C,D). intracellular tangles seen in ganglioneuromas (Bender and Ghatak, 1978).…”

Section: Discussionmentioning

confidence: 99%

Retardation of neuritic outgrowth and cytoskeletal changes accompany acetylcholinesterase inhibitor treatment in cultured rat dorsal root ganglion neurons

Dupree

Bigbee

1994

J of Neuroscience Research

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“…Although well differentiated, the ganglion cells vary in size, often being multinucleate, and contain Nissl substance in varying quantity; axons and Schwann sheaths are often bundled in pseudofascicles. Cytoplasmic vacuoles, inclusions, and even features of neurodegenerative change such as Pick bodies maybe seen [20] .…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance neurography in the diagnosis of a retroperitoneal ganglioneuroma: Case report and literature review

Silveira¹,

Vieira²,

Pereira³

et al. 2018

Radiology Case Reports

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Magnetic resonance neurography is a technique for identifying anatomy and pathologic lesions of nerves, and has emerged as a helpful technique for localizing lesions and elucidating the underlying etiology. Ganglioneuromas are highly differentiated benign tumors. This lesion is rare and exhibits undetermined symptoms, the features of using the magnetic resonance neurography are a great ally to determine its diagnosis. The authors illustrate a case of retroperitoneal ganglioneuroma emphasizing its image characteristics using magnetic resonance neurography with the diagnosis confirmed by histopathological examination.

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“…Because of the primitive nature of this tumor, however, its exact histogenesis and differentiating potential have been debated and have been extensively reviewed. 3,5,36 Although some authors have suggested the existence of neuroblastic differentiation in some medulloblastomas based on light microscopic 25,36,40,4 l ,4.5. 46 definitive evidence of neuronal differentiation has rarely been documented ultrastructurally.'"…”

mentioning

confidence: 99%

Cerebellar “neuroblastoma”: Nosology as it relates to medulloblastoma

Pearl

Takei

1981

Cancer

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Medulloblastoma is a relatively common and well-established entity, consisting of primitive, multipotential cells that may exhibit some evidence of neuroblastic or glial differentiation. However, cerebellar "neuroblastoma" with ultrastructural evidence of significant neuroblastic differentiation are extremely rare. We have studied three tumors with light microscopic evidence of neuroblastic differentiation. All of these tumors have regions resembling medulloblastoma; this finding suggests that cerebellar "neuroblastoma" represents one form of medulloblastoma. These cases provide further evidence for the potential medulloblastoma cells to differentiate along neuronal lines.

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Light and electron microscopic observations on a ganglioneuroma

Cited by 31 publications

References 10 publications

Retardation of neuritic outgrowth and cytoskeletal changes accompany acetylcholinesterase inhibitor treatment in cultured rat dorsal root ganglion neurons

Retardation of neuritic outgrowth and cytoskeletal changes accompany acetylcholinesterase inhibitor treatment in cultured rat dorsal root ganglion neurons

Magnetic resonance neurography in the diagnosis of a retroperitoneal ganglioneuroma: Case report and literature review

Cerebellar “neuroblastoma”: Nosology as it relates to medulloblastoma

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