Cerebellar “neuroblastoma”: Nosology as it relates to medulloblastoma

Pearl, Gary S.; Takei, Yoshio

doi:10.1002/1097-0142(19810215)47:4<772::aid-cncr2820470423>3.0.co;2-e

Cited by 56 publications

(24 citation statements)

References 40 publications

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“…Hi stological features Cerebral neuroblastomas were classified into three histological types by Horten and Rubinstein (1976 (Sin et al 1978;Yagishita et al 1980;Pearl and Takei, 1981;Yagishita et al 1982). Although Hormer-Wright rosettes is often seen in cerebral neuroblastomas (Horten and Rubinstein, 1976;Rubinstein, 1985), Hormer-Wright rosettes have been rarely found in cerebellum of reported cases (Robey et al 1988).…”

Section: Discussionmentioning

confidence: 99%

“…These cell processes contain microtubles and many densecore vesicles or clear vesicles with a diameter of 50-100 nm, which are considered to be secretory granules (Shin et al 1978;Hirano and Shin, 1979;Yagishita et al 1980;Pearl and Takei, 1981;Yagishita et al 1982;Warzok et al 1983;Chadarevian et al 1987;Robey et al 1988;Yagishita et al 1991). Some tumors (Shin et al 1978;Hirano and Shin, 1979;Pearl and Takei, 1981) show synaptic structures, but others do not (Yagishita et al 1980(Yagishita et al , 1982Chadarevian et al 1987;Robey et al 1988).…”

Section: Discussionmentioning

confidence: 99%

“…Some tumors (Shin et al 1978;Hirano and Shin, 1979;Pearl and Takei, 1981) show synaptic structures, but others do not (Yagishita et al 1980(Yagishita et al , 1982Chadarevian et al 1987;Robey et al 1988). However, we consider that the presence of synaptic structures only show the degree of neuroblastic differentiation.…”

Section: Discussionmentioning

confidence: 99%

“…However, we consider that the presence of synaptic structures only show the degree of neuroblastic differentiation. Some authors (Pearl and Takei, 1981;Yagishita et al 1982) mentioned the relationship between medulloblastomas and cerebellar neuroblastomas. Especially, the histological similarities of desmoplastic medulloblastomas and cerebellar neuroblastomas were discussed.…”

Section: Discussionmentioning

confidence: 99%

“…This tumor usually occurs in the superficial cerebellar hemisphere. Neuroblastomas are a definitely intraparechymal vermian tumor of infants (Shin et al 1978;Hirano and Shin, 979;Yagishita et al 1980;Pearl and Takei, 1981;Yagishita et al 1982;Warzok et al 1983;Chadarevian et al 1987;Robey et al 1988;Yagishita et al 1991).…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Neuroblastomas of the Central Nervous System. Clinicopathological Features of a Cerebellar Neuroblastoma in Comparison with a Metastatic Cerebral Neuroblastoma.

et al. 1994

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Neuroblastomas of the Central Nervous System. Clinicopathological Features of a Cerebellar Neuroblastoma in Comparison with a Metastatic Cerebral Neuroblastoma.

et al. 1994

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Medulloblastoma: The identification of prognostic subgroups and implications for multimodality management

Kopelson

Linggood

Kleinman

1983

Cancer

104

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For 43 medulloblastoma patients who had five‐and ten‐year actuarial survival rates of 56%, prognostic factors of statistical significance included: T‐stage (82% T1,2; versus 46% T3,4; P < 0.02), M‐stage (63% M0,1 versus 0% M2,3; P < 0.03), and histopathologic tumor score (TS, based upon necrosis, desmoplasia, cytoplasmic processes, and mitoses) (81% TS ⩽ 5 versus 41% TS ⩾ 6; P < 0.05). Posterior fossa local control rates were also function of T‐stage (90% T1,2 versus 38% T3,4) and TS (83% TS ⩾ 5 versus 38% TS ⩾ 6). Combining TS with T‐stage, patients fell into three prognostic and local control groups, which may have different future management implications: Small (T1,2) tumors of favorable (TS ⩽ 5) histology had a 92% ten‐year actuarial survival rate with 100% (8/8) local control; no change from current management is suggested. For the intermediate prognosis group (T1,2‐TS ⩽ 6 or T3,4‐TS ⩾ 5 with 67% and 70% survival, respectively), increasing the irradiation dose alone may improve survival because these tumors exhibited an irradiation dose‐response relationship. However, it is the poor prognosis group (T3,4‐TS ⩾ 6 with 42% survival) which might be suitable for future adjuvant chemotherapy or radiosensitizer trials since there is no evidence that higher irradiation doses improve local control. This article identifies prognostic subgroups based on histologic type and TM staging in medulloblastoma patients which potentially may be utilized to improve therapeutic results, and confirms the value of staging patients with central nervous system malignancies.

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Medullomyoblastoma. A histologic, immunohistochemical, and ultrastructural study

Smith

Davidson

1984

Cancer

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The light and electron microscopic features of a medullomyoblastoma arising in the cerebellar vermis of a 3‐year‐old boy are described. Differentiation along both glial and neuronal lines was present in the medulloblastoma component of the tumor. Astroytic differentiation was confirmed by the observation of compact bundles of 8 to 10 nm glial filaments in cellular processes on ultrastructural examination, and by positive immunostaining for glial fibrillary acidic protein (GFAP). Neuroblastic differentiation was suggested by the demonstration of axon‐like processes on silver impregnation, and ultrastructurally by the observation of microtubules, dense‐core and clear vesicles, and rare synapse‐like structures within cytoplasmic processes. The presence of both primitive and well‐differentiated striated muscle fibers in the tumor was confirmed by the demonstration of thick and thin myofilaments and Z bands on electron microscopy, and by positive immunostaining for myoglobin. These findings clearly establish the presence of both neuroectodermal and rhabdomyoblastic components in this neoplasm, and thus set it apart from the pure rhabdomyosarcomas, which may also occur in the cerebellar vermis in children. This case also illustrates the usefulness of electron microscopy and immunohistochemistry in the diagnosis and histogenetic evaluation of primitive or poorly differentiated small cell tumors of the central nervous system.

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Cerebellar “neuroblastoma”: Nosology as it relates to medulloblastoma

Cited by 56 publications

References 40 publications

Neuroblastomas of the Central Nervous System. Clinicopathological Features of a Cerebellar Neuroblastoma in Comparison with a Metastatic Cerebral Neuroblastoma.

Neuroblastomas of the Central Nervous System. Clinicopathological Features of a Cerebellar Neuroblastoma in Comparison with a Metastatic Cerebral Neuroblastoma.

Medulloblastoma: The identification of prognostic subgroups and implications for multimodality management

Medullomyoblastoma. A histologic, immunohistochemical, and ultrastructural study

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