Ligational behavior of S, N, and O donor quinoxaline derivatives toward the later first-row transition metal ions

Abstract

Ligands derived from quinoxaline-2,3-(1,4H)-dithione are treated with Co(II), Ni(II), Cu(II), and Zn(II) chlorides to yield stable complexes. The prepared compounds are characterized by spectro-analytical techniques and magnetic susceptibility measurements, and the coordination behavior of ligands is discussed. All the complexes are octahedral and mononuclear with general formula [MLCl 2 (H 2 O)]. The electrochemical behavior of the synthesized compounds was investigated by cyclic voltammetry studies and the redox activity is explained.

Synthesis, characterization and in vitro anticancer, DNA binding and cleavage studies of Mn (II), Co (II), Ni (II) and Cu (II) complexes of Schiff base ligand 3‐(2‐(1‐(1H‐benzimidazol‐2‐yl)ethylidene)hydrazinyl)quinoxalin‐2(1H)‐one and crystal structure of the ligand

“…Several derivatives of quinoxaline were reported to exhibit a wide range of pharmacological activities such as antimicrobial, anti‐inflammatory, antidiabetic, antitumour and antidepressant activities, in addition to their use in catalysis and organic synthesis . Schiff base ligands derived from quinoxaline are extensively employed in the synthesis of metal complexes with a variety of geometries and varied analytical, industrial and pharmaceutical applications . The design of Schiff bases of 3‐hydrazinylquinoxalin‐2(1 H )‐one has been of interest due to the predictable coordination properties of the ligands and their prominent pharmacological activities …”

Transition Metal Complexes of 4-Aminoantipyrine Derivatives and Their Antimicrobial Applications

“…A range of bidentate to tetradentate ligands of end-off compartmental type to scorpionate type to macrocyclic type mode of coordination have been developed using 4-aminoantipyrine. The coordination cavities offered by the 4-aminoantipyrine Schiff base derivatives, which mostly consist of N, O and/or S donor atoms were found to be most suitable for the transition metal ions [ 56 , 57 ]. A range of unique transition metal complexes have been developed using these derivatives, with the majority being late 3 d -transtion metal complexes (viz .…”

A copper(II) complex with a thioether and ether containing azophenol ligand: Synthesis, spectra, X-ray structure and DFT computations

“…The potential role played by copper(II), being present in the active site of a large number of metalloproteins, has inspired the design of new copper(II) complexes with N,S donor ligand frames as models to provide a better understanding of biological systems and for assisting in the development of new homogeneous catalysts for selective catalytic reactions [18][19][20][21][22][23][24][25]. The metal chelate complexes, especially N,S donor complexes of copper(II), have been paid considerable attention because of their application as nuclear medicine and anticancer drugs [26,27].…”