Transition Metal Complexes of 4-Aminoantipyrine Derivatives and Their Antimicrobial Applications

Abstract

Transition metal complexes of 4-aminoantipyrine derivatives have been gaining great interest due to their rich coordination chemistry and potential applications in the field of pharmaceutical science. The presence of a free amine and a cyclic ketone functionality makes 4-aminoantipyrine an attractive amphoteric substrate for Schiff base formation. Varieties of aldehydes/ketones or amines of versatile steric, electronic and functional nature could be condensed with the 4-aminoantipyrine motif to obtain the ligand systems of multi-denticity and diverse coordination behaviour. The transition metal complexes obtained from these ligand systems exhibit unique structural and functional properties. This review compiles the important transition metal complexes developed from the Schiff base derivatives of 4-aminoantipyrine, and their utility as antibacterial and antifungal agents. Rationale of the strategies involved in the development of highly potential antimicrobial agents is discussed.

A polynuclear CuIIBiIII complex with antipyrine‐derived Schiff‐base: Preparation, characterization, and biological evaluations

“…vulgaris ) and fungi ( C . albicans ), which were found to be good activity about 65 μM 47 . Al‐Obaidi reported that dinuclear Cu (II) and Co (II) complexes of Schiff base derived from 4‐aminoantipyrine with salicylaldehyde were prepared.…”

“…Four metal complexes showed moderate antimicrobial activity against bacteria (S. aureus, B. subtilis, and P. vulgaris) and fungi (C. albicans), which were found to be good activity about 65 μM. 47 Al-Obaidi reported that dinuclear Cu (II) and Co (II) complexes of Schiff base derived from 4-aminoantipyrine with salicylaldehyde were prepared. Copper (II) complexes have moderate effect on S. aureus.…”

A selective chemosensor via click chemistry for Cu2+ and Hg2+ ions in organic media

“…Antipyrine and its derivatives have provoked boundless interest, especially in medicine, due to the wide range of pharmacological activities and therapeutic applications, such as the antibacterial, antifungal, analgesic, antitumor, antipyretic, and anti-inflammatory activity of antipyrine. [23][24][25][26] A few intriguing fluorescent sensors based on antipyrine have also been produced. [27][28][29][30] Most of the effort has been concentrated on synthesis, structure characterization, and biological evaluation of antipyrine derivatives.…”