Leptospirosis: pathogenesis, immunity, and diagnosis

Palaniappan, Raghavan U.M.; Ramanujam, Subbupoongothai; Chang, Yung-Fu

doi:10.1097/qco.0b013e32814a5729

Cited by 162 publications

(126 citation statements)

References 154 publications

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“…[1][2][3][4][5] Hu mans con tract the di se a se vi a di rect or in di rect con tact of the uri ne of the in fected ani mals. Ro dents are the ma in ma in te nan ce hosts.…”

Section: Discussionunclassified

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Leptospiral Lymphadenopathy: Case Report

Ekinci¹,

Turhan²,

Haholu³

et al. 2011

Turkiye Klinikleri J Med Sci

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744eptospirosis is presumed to be the most widespread zoonosis in the world. 1 The disease can affect many organ systems by its capability of extensive vascular damage. Lymph node involvement is recognized. We report a case of leptospirosis with epitrochlear lymphadenopathy as its predominant finding, which is an unexpected presentation. CASE REPORTA 21-year-old male patient, a military personnel working in the radiator department, was admitted to the clinic with complaints of fever, chills, headache, dizziness, malaise and myalgias of sudden onset, and he was administered cefuroxime 500 mg bid for five days with a diagnosis of upper respiratory infection in the local infirmary. He had a bruise with a crusted surface of 0.5 Leptospiral Lymphadenopathy:Case Report A AB BS S T TR RA AC CT T Lep tos pi ro sis is a zo o no tic in fec ti o us di se a se that can in vol ve many or gans and it has variable ma ni fes ta ti ons. In this pa per, we des cri be epit roch le ar lymph no de in vol ve ment as an isola ted fin ding in a ca se of anic te ric lep tos pi ro sis, that, to our know led ge, has not be en pre vi o usly repor ted. The lymph no de was ex ci sed and light mic ros copy sho wed en lar ged se con dary fol lic les with pro mi nent ger mi nal cen ters, so me with bi zar re sha pes along with an in cre a se in high en dot he li al ve nu les. A Wart hin-Starry sta in re ve a led spi roc he tal or ga nisms which we re cork-screw sha ped with ho o ked ends. Se ro logy for lep tos pi ra con fir med this bac te ri um as the eti o logy of the re ac ti ve lympha de no pathy whi le tests for syphi lis and bor re li o sis we re ne ga ti ve.K Ke ey y W Wo or rd ds s: : Lep tos pi ro sis; lympha de ni tis Ö ÖZ ZE ET T Lep tos pi roz bir çok or ga nı tu ta bi len zo o no tik en fek si yöz bir has ta lık tır ve de ğiş ken be lir tile ri var dır. Bu ya zı da biz, bil di ği miz ka da rıy la da ha ön ce bil di ril me miş anik te rik lep tos pi roz lu bir ol gu da izo le bul gu ola rak epit rok le ar lenf no du tu tu lu mu ta nım la mak ta yız. Lenf no du ek si ze edildi ve ışık mik ros ko bu yük sek en do tel yal ve nul ler de bir ar tış ve ba zı la rı ga rip şekil li be lir gin ger minal mer kez le ri olan bü yü müş se kon der fo li kül le ri gös ter di. Wart hin-Starry bo ya sı kan ca uç lu man tar vi da sı şekil li spi ro ke tal or ga niz ma la rı or ta ya koy du. Si fi liz ve bo rel yoz için test ler ne ga tif iken lep tos pi ra se ro lo ji si ise re ak tif len fa de no pa ti ne de ni nin bu bak te ri ol du ğu nu doğ ru la dı.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Lep tos pi ro zis; len fa de nit T Tu ur rk ki iy ye e K Kl li in ni ik kl le er ri i J J M Me ed d S Sc ci i 2 20 01 11 1; ;3 31 1( (3 3) ): :7 74 44 4--7 7

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“…[1][2][3][4][5] Hu mans con tract the di se a se vi a di rect or in di rect con tact of the uri ne of the in fected ani mals. Ro dents are the ma in ma in te nan ce hosts.…”

Section: Discussionunclassified

“…8,9 Two spe ci es of lep tos pi res are re cog ni zed, the sap roph ytic Lep tos pi ra bif le xa and pat ho ge nic Lep tos pi ra in ter ro gans. 3,5,8 Cli ni cally, the di se a se has two forms: anic te ric and ic te ric. The anic te ric form is mostly asym ptoma tic.…”

Section: Discussionmentioning

confidence: 99%

Leptospiral Lymphadenopathy: Case Report

Ekinci¹,

Turhan²,

Haholu³

et al. 2011

Turkiye Klinikleri J Med Sci

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show abstract

“…La mayoría de las ocasiones (90%) produce una forma anictérica, como el caso descrito. Asimismo puede producir una forma grave de afectación sistémica (fiebre icterohemorrágica o síndrome de Weil) (2)(3)(4). En nuestro medio es una enfermedad poco frecuente, y en las series publicadas la mayoría de los enfermos presentaban un antecedente epidemiológico característico de esta infección (5).…”

Section: Zoonosis Emergentesunclassified

Zoonosis emergentes

Miranda

Aizpuru

García

et al. 2008

An. Med. Interna (Madrid)

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“…1 The disease was first recognized as an occupational disease of sewer workers in 1883. In 1886, Weil described the clinical manifestations in four men who had severe jaundice, fever and haemorrhage with renal involvement.…”

mentioning

confidence: 99%