Laryngeal precursor lesions: Interrater and intrarater reliability of histopathological assessment

Abstract

4. Laryngoscope, 128:2375-2379, 2018.

Regarding Laryngeal precursor lesions: Interrater and intrarater reliability of histopathological assessment

“…We do not agree with the authors that the 2017 WHO system has been created without consideration of any additional biomarkers of potential prognostic value . Several studies of biomarkers, cited in the article published in 2009, supported the concept of the LC, which provides together with the amended LC the foundation of the morphological criteria for the 2017 WHO classification.…”

“…The authors of the article “Laryngeal Precursor Lesions: Interrater and Intrarater Reliability of Histopathological Assessment” drew attention to an unfortunate error that occurred in the current World Health Organization ( WHO ) Classification of Head and Neck Tumours , chapter 3, Precursor Lesions . Their finding should be highlighted to prevent varying estimations of laryngeal precursor lesions (LPL).…”

“…4 We do not agree with the authors that the 2017 WHO system has been created without consideration of any additional biomarkers of potential prognostic value. 1 Several studies of biomarkers, cited in the article published in 2009, 3 supported the concept of the LC, which provides together with the amended LC the foundation of the morphological criteria for the 2017 WHO classification. None of them, including very recent molecular studies, 7,8 can replace morphological data as the leading guidance for clinicians in selecting appropriate treatment and evaluating the risk of progression.…”

Developing Classifications of Laryngeal Dysplasia: The Historical Basis

“…He also emphasises the importance of an increased number of dyskeratotic cells appearing throughout the entire epithelium as indicative of the presence of significant dysplasia [47]. Others regard the 2017 WHO classification as a potential source of disunity regarding the number of grades and morphological criteria and pointing out that the system creates difficulties in providing reliable diagnosis of laryngeal precursor lesions [64]. Further correspondence on this issue can be read in the recent Letters to the Editor of The Laryngoscope [62,65].…”

In response to Laryngeal precursor lesions: Interrater and intrarater reliability of histopathological assessment

“…We thank Dr. Gale and her colleagues for their response to our article, "Laryngeal Precursor Lesions: Interrater and Intrarater Reliability of Histopathological Assessment," 1 and we are pleased that The Laryngoscope has given us the opportunity to respond to their letter to the editor. Also, we appreciate that our well-reputed colleagues acknowledge our finding of an unfortunate error in the reference book WHO Classification of Head and Neck Tumours, 2 and that they recommend that our findings be highlighted.…”