Pest affects plants in nature worldwide, leading to excess use of mineral fertilizers and toxic pesticides, effecting environments, plants, animal and causes serious health problems to farmers. The indiscriminate use of bio pesticide has led pest resistance, reduce soil fertility and finally there is an emergence of novel product to intercept the pest situation. Nanoscience a new discipline have great deal of application in various fields and may also be useful in agrochemical and plant protection area to control pest to considerable extent. Until now, nanoparticles were used in formulation of nano based pesticides and insecticides, encapsulated nanoparticles, nanoparticle-mediated gene or DNA transfer in plants and bio sensors for remote sensing for precision farming. The nanopesticides of biological origin named as bio-nanopesticide could be fabricated using any metal such as Ag, Cu, SiO2, ZnO with broad-spectrum pest protection efficiency. However, extensive research and spectrum of various field studies are specially required to develop understanding of interaction between nanoparticles, microorganisms, soil, plants and humans. In present paper, a critical analysis is addressed in a problem of pest in field and usage of conventional solution and nano bio pesticides for applications in crop protection systems.