Lack of sex differences to the subjective effects of nitrous oxide in healthy volunteers

Zacny, James P.; Jun, Jenny M.

doi:10.1016/j.drugalcdep.2010.06.008

Cited by 10 publications

(8 citation statements)

References 24 publications

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“…Apelin levels were lowered in individuals with essential hypertension, regardless of systolic or diastolic dysfunction in the left ventricle (22) and treatment with apelin re-duced systolic blood pressure in hypertensive rats through NO-dependent signaling (23) . In this study, we did not find any relation between apelin and NO on one side and sex on the other side as mentioned by other studies (24).…”

Section: Discussionsupporting

confidence: 46%

Association Between Apelin and Nitrous Oxide with Essential Hypertensive Patient and their Relation toSex

kadry

Ahmed

et al. 2022

Sohag Medical Journal

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Apelin is a new multi-functional peptide that has already been linked to blood pressure and cardiac function modulation. It's hypothesized to play a role in hypertension and hypertensive heart diseases development., Nitric oxide (NO) was recognized as an endogenous signaling molecule that modulates vascular compliance and organ perfusion via its powerful vasodilatory effects. Hypertension, atherosclerosis, and chronic renal problems are hypothesized to limit nitric oxide bioavailability, leading to disease progression. Our study aimed to know the role of apelin and nitric oxide in the pathogenesis of essential hypertension and correlate the levels of apelin to nitric oxide in both genders, A total number of 90 participants (70 hypertensive patients and 20 control) were enrolled, and all participants underwent blood pressure, serum apelin and nitric oxide measurement, our results revealed decreased serum apelin levels in essential hypertensive patients, while serum nitric oxide was increased compared to controls with no significant gender difference.

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Section: Discussionsupporting

confidence: 46%

Association Between Apelin and Nitrous Oxide with Essential Hypertensive Patient and their Relation toSex

kadry

Ahmed

et al. 2022

Sohag Medical Journal

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“…The DEQ has been used with a wide range of substances. Some examples include alcohol (King et al , 2011, Reed et al , 2012), alprazolam (Evans and Levin, 2002), amphetamine (Dlugos et al , 2011, Hamidovic et al , 2010), baclofen (Evans and Bisaga, 2009); buprenorphine and methadone (Comer et al , 2005a), cocaine and lidocaine (Fischman et al , 1983), heroin (Comer et al , 2005b), methamphetamine (Johnson et al , 2005), MDMA (Harris et al , 2002), morphine (Webster et al , 2011), nicotine (Sofuoglu et al , 2012), nitrous oxide (Zacny and Jun, 2010), oxycodone (Webster et al , 2012), pentobarbital (Cole-Harding and de Wit, 1992), and tetrahydrocannabinol (Phan et al , 2008, Wachtel and de Wit, 2000). …”

mentioning

confidence: 99%

The drug effects questionnaire: psychometric support across three drug types

et al. 2012

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Rationale The Drug Effects Questionnaire (DEQ) is widely used in studies of acute subjective response (SR) to a variety of substances, but the format of the DEQ varies widely across studies, and details of its psychometric properties are lacking. Thus, the field would benefit from demonstrating the reliability and validity of the DEQ for use across multiple substances. Objective The current study evaluated the psychometric properties of several variations of DEQ items, which assessed the extent to which participants (1) feel any substance effect(s), (2) feel high, (3) like the effects, (4) dislike the effects, and (5) want more of the substance using 100mm Visual Analog Scales. Methods DEQ data from three placebo-controlled studies were analyzed to examine SR to amphetamine, nicotine, and alcohol. We evaluated the internal structure of the DEQ for use with each substance as well as relationships between scale items, measures of similar constructs, and substance-related behaviors. Results Results provided preliminary psychometric support for items assessing each DEQ construct (FEEL, HIGH, DISLIKE, LIKE, and MORE). Conclusions Based on the study results, we identify several common limitations of extant variants of the DEQ and recommend an improved version of the measure. The simplicity and brevity of the DEQ combined with its promising psychometric properties support its use in future SR research across a variety of substances.

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“…Klingberg et al, 20 stated that dental anxiety is more prevalent in females. However, Zacny and Jun 21 reported that there was no difference in the subjective effects of NOIS at low concentrations among the gender of the participants. In the present study, a gender-wise comparison of the level of sedation was analyzed within both the groups respectively and between the groups.…”

Section: Discussionmentioning

confidence: 94%

Comparative Assessment of Anxiety during Inferior Alveolar Nerve Block under Nitrous Oxide + Oxygen and Oxygen Inhalation Sedation in Children Aged 3–12 Years: A Randomized Clinical Trial

Dave¹,

Thomas²,

Shah³

et al. 2023

International Journal of Clinical Pediatric Dentistry

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A bstract Aim A comparative evaluation of children's anxiety with the use of nitrous oxide–oxygen (N 2 O–O 2 ) inhalation sedation during the administration of inferior alveolar nerve block (IANB). Materials and methodology A total of 60 children between 3 and 12 years of age, with Frankl's behavior rating of 2–3 requiring IANB for any dental procedure were enrolled in this randomized clinical study. Group I ( n = 30) received N 2 O and oxygen inhalation sedation at a concentration in the range of 25–50%, whereas group II ( n = 30) received 100% O 2 as a placebo. The physiological parameters like pulse rate, respiration, blood pressure, and O 2 saturation were measured at the baseline, intraoperatively [during and after administration of local anesthesia (LA)] and postoperatively after the termination of the gases in both groups. The sedation level was measured intraoperatively (before administration of LA) using the Ramsay Sedation Score (RSS). The discomfort and anxiety were measured at the baseline, intraoperatively, and postoperatively using the Face, Legs, Activity, Cry, Consolability (FLACC) behavior scale. The data were evaluated using the statistical software International Business Machines (IBM) Statistical Package for the Social Sciences (SPSS) statistics 20.0. Results There was a significant difference in the FLACC scores between the two groups, intraoperatively ( p -value—0.002), and postoperatively ( p -value—0.049). The mean of the RSS for group I was 2.80 + 1.03, and for group II was 1.80 + 0.81. All the physiological parameters recorded were within the normal range. Conclusion The use of N 2 O–O 2 inhalation improved the anxiety levels in children while receiving the IANB and showed significant anxiolytic and sedative effects as compared to O 2 inhalation. Clinical significance Nitrous oxide–oxygen (N 2 O–O 2 ) inhalation can be used as a nonpharmacological behavior management adjunct for invasive treatments for children with utmost comfort for the child. How to cite this article Thomas PS, Dave BH, Shah DJ, et al. Comparative Assessment of Anxiety during Inferior Alveolar Nerve Block under Nitrous Oxide + Oxygen and Oxygen Inhalation Sedation in Children Aged 3–12 Years: A Randomized Clinical Trial. Int J Clin Pediatr Dent 2023;16(1):30-36.

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Lack of sex differences to the subjective effects of nitrous oxide in healthy volunteers

Cited by 10 publications

References 24 publications

Association Between Apelin and Nitrous Oxide with Essential Hypertensive Patient and their Relation toSex

Association Between Apelin and Nitrous Oxide with Essential Hypertensive Patient and their Relation toSex

The drug effects questionnaire: psychometric support across three drug types

Comparative Assessment of Anxiety during Inferior Alveolar Nerve Block under Nitrous Oxide + Oxygen and Oxygen Inhalation Sedation in Children Aged 3–12 Years: A Randomized Clinical Trial

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