Association Between Apelin and Nitrous Oxide with Essential Hypertensive Patient and their Relation toSex

Abstract

Apelin is a new multi-functional peptide that has already been linked to blood pressure and cardiac function modulation. It's hypothesized to play a role in hypertension and hypertensive heart diseases development., Nitric oxide (NO) was recognized as an endogenous signaling molecule that modulates vascular compliance and organ perfusion via its powerful vasodilatory effects. Hypertension, atherosclerosis, and chronic renal problems are hypothesized to limit nitric oxide bioavailability, leading to disease progression. Our study aimed to know the role of apelin and nitric oxide in the pathogenesis of essential hypertension and correlate the levels of apelin to nitric oxide in both genders, A total number of 90 participants (70 hypertensive patients and 20 control) were enrolled, and all participants underwent blood pressure, serum apelin and nitric oxide measurement, our results revealed decreased serum apelin levels in essential hypertensive patients, while serum nitric oxide was increased compared to controls with no significant gender difference.