Laboratory Tests Need for  Plasma Lipids and Liver Enzymes During Oral IsotretioinTreatment

Çetinkaya, Reyhan; Yaldız, Mahizer; Solak, Berna

doi:10.5455/ijmrcr.oral-isotretioin-treatment

Cited by 2 publications

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“…14 Also, a study done in Sakarya University, Turkey, found no relation statistically between the third and sixth months of treatment in all parameters including cholesterol and TG. 15 Regarding triglyceride level readings, we noticed that almost all the patients had a normal baseline (90.9%) and both second (95.5%) and last (94.3%) follow-up readings. The same study done in Al Qassim, KSA showed that TG levels were normal at baseline of patients at 93.5% and at follow-up 83.7%.…”

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confidence: 78%

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Isotretinoin-Induced Dyslipidemia: a Single-Center Study in Saudi Arabia

Al Dhafiri,

Kaliyadan,

Almukhaimar

et al. 2024

PPA

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Purpose Acne is a chronic inflammatory skin disease with a high prevalence in Saudi Arabia. Isotretinoin is used to treat severe, resistant nodulocystic acne. Side effects include joint discomfort, headache, mucosal dryness, and nose bleeds. Elevated lipids and liver enzymes have also been recorded. The study goal is to identify the prevalence of increased lipid levels during and after isotretinoin use. Patients and Methods This retrospective study was conducted in the dermatology polyclinic at King Faisal University, Al-Ahsa, Saudi Arabia. It included adults of different age groups diagnosed with acne vulgaris and treated with oral isotretinoin between January 2021 and December 2022. Parameters included baseline laboratory tests and follow-up laboratory results of cholesterol and triglycerides. Results Among 88 patients, 48.9% were aged 21–23 years, with females dominating. In total, 47.7% of patients started using isotretinoin at age 20 years or less, with starting doses ranging from 10 to 20 mg. Fifty percent of the patients had five months or more of treatment duration and only 6.8% of the patients had previously used isotretinoin. For the cholesterol and triglycerides, 87.5% of patients had normal pre-treatment with cholesterol and 90.9% with triglycerides, followed by 81.8% and 95.5% in the second reading, respectively. In the last reading, results were 77.3% for cholesterol and 94.3% for triglycerides. Conclusion The study found that most acne patients treated with isotretinoin had normal cholesterol and triglyceride levels at baseline, second, and last readings. The incidence of higher laboratory alterations was low, with 12.5% and 4.5% for cholesterol and triglycerides at baseline, and 18.2% and 3.4% at second, and 22.7% and 5.7% at last readings. Overall, age, gender, age of start of isotretinoin, isotretinoin dose, and previous use of isotretinoin are factors that could affect laboratory readings.

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confidence: 78%

“… 14 Also, a study done in Sakarya University, Turkey, found no relation statistically between the third and sixth months of treatment in all parameters including cholesterol and TG. 15 …”

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confidence: 99%

Isotretinoin-Induced Dyslipidemia: a Single-Center Study in Saudi Arabia

Al Dhafiri,

Kaliyadan,

Almukhaimar

et al. 2024

PPA

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Effect of Isotretinoin Oral on Acne Vulgaris (A Review of Systematic and Metaanalysis Studies on Alanine Aminotransferase Levels, Aspartate Aminotransferase, Lipid Profile, Homeostatic Model Assessment for Insulin Resistance, Complete Blood Count, Fasting Blood Glucose)

Kusumaningsih

Widayati

Malik

et al. 2021

ijsr

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Background: Oral isotretinoin is known to has a large role in the treatment of acne vulgaris, but unfortunately has signicant side effects. Observation of laboratory changes during oral isotretinoin intake is important in order to ensure safety. Medline Pubmed, Scopus, Methods: ProQuest, Cochrane library, ClinicalTrials.gov, the reference list, conference proceedings, researchers in eld of eligible studies were searched. Result: 17 studies (1573 patients) were included into meta-analysis. Mean difference values (95% CI) increase for triglycerides 25,81 mg/dL, total cholesterol 16,11 mg/dl, Low-Density Lipoprotein cholesterol (LDL) 15,11 mg/dL, Aspartate Aminotransferase (AST) 3,08 U/L, Alanine Aminotransferase (ALT) 1.61 U/L, hemoglobin 0,18 g/dl, fasting glucose 0,55mg/dL. High-Density Lipoprotein cholesterol (HDL) decrease 3,09 3 3 mg/dl, White Blood Cell (WBC) decrease 0.23 x10 /μL, neutrophils decrease 0,26 x10 /μL. The qualitative analysis found that HOMA IR had increase in mean value. Longer laboratory evaluation time, can reduce the cost Conclusion: of treatment and discomfort of patients in acne therapy. Acne patient with abnormal baseline values of laboratory parameters should avoid taking oral isotretinoin

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Laboratory Tests Need for Plasma Lipids and Liver Enzymes During Oral IsotretioinTreatment

Cited by 2 publications

References 0 publications

Isotretinoin-Induced Dyslipidemia: a Single-Center Study in Saudi Arabia

Isotretinoin-Induced Dyslipidemia: a Single-Center Study in Saudi Arabia

Effect of Isotretinoin Oral on Acne Vulgaris (A Review of Systematic and Metaanalysis Studies on Alanine Aminotransferase Levels, Aspartate Aminotransferase, Lipid Profile, Homeostatic Model Assessment for Insulin Resistance, Complete Blood Count, Fasting Blood Glucose)

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