BACKGROUND: Acne vulgaris (AV) is a chronic inflammatory disease in the pilosebaceous unit. Recent research has begun to focus on the essential relationship between oxidative stress and the pathogenesis of AV. The use of antioxidants like coenzyme Q10 (CoQ10) that has various advantages as adjuvant therapy is expected to be beneficial for AV. AIM: The study was aimed to analyze the effect of CoQ10 supplementation on serum SOD levels and the severity of AV patients. METHODS: A double blind-randomized controlled trial was carried out on 36 patients with AV and classified according to severity degree of AV. These patients were randomly divided into two groups (treatment group with tretinoin 0.025% cream and once-daily supplementation of CoQ10 100 mg tablet; and placebo group with tretinoin 0.025% cream and once-daily placebo tablet). Response to treatment was based on serum superoxide dismutase (SOD) level and AV severity degree. RESULTS: Administration of CoQ10 to AV patients significantly increase serum SOD level (p = 0.008) and improves the severity of AV after 8 weeks (p = 0.008). CONCLUSION: CoQ10 supplementation can increase serum SOD levels and improve the severity of AV.

Objective: This study aimed to analyze the physical stability and drug content of zoledronate (ZOL) gel emulsion in virgin coconut oil (VCO) as a newpharmaceutical product at 25°C as room temperature and 40°C as an accelerated temperature for a stability physics test.Methods: The ZOL gel emulsion comprises the following ingredients: 0.16% ZOL powder, 2% carboxymethyl cellulose, 5% VCO, 0.44% sodiumbenzoate, and 0.009% antioxidant butylated hydroxytoluene, and distilled water. Samples of this gel emulsion were stored for 1 month at 25°C and40°C, and the parameters used for stability tests were pH, viscosity, spreadability, and adhesive strength. The drug content was also evaluated with aspectrophotometer. The ZOL gel emulsion was evaluated against these metrics on days 1, 7, 14, and 28.Results: The results showed that ZOL pH, viscosity, spreadability, adhesive strength, and drug content gel emulsion were clinically stable over 28 daysof storage at 25°C, whereas it was not stable when stored at 40°C for the same duration. pH value of ZOL gel emulsion significantly decreased at 28 days(p<0.05). Also for viscosity, adhesive strength, and drug content of ZOL gel emulsion showed statistically significant (p<0.05), except for spreadabilityvalue (p>0.05). The spreadability value between ZOL gel emulsion that stored at 25°C and at 40°C showed no significant result at 7 and 14 days (p>0.05).Conclusion: ZOL gel emulsion was stable at 25°C when stored for 28 days, suggesting that this is a suitable storage temperature at which its physicalstability and drug content can be maintained.

Karsinoma sel basal (KSB) tercatat sebanyak 75% dari semua kanker kulit. Data epidemiologis dunia menunjukkan peningkatan insidensi KSB 3-10% dalam setahun, hal ini diduga berkaitan dengan penipisan lapisan ozon (2% dalam 20 tahun terakhir) dan perubahan gaya hidup. Karsinoma sel basal (KSB) dapat menyebabkan cacat kosmetik maupun cacat fungsional sehingga diperlukan diagnosis dini dan penatalaksanaan yang tepat. Seorang perempuan 72 tahun, dengan keluhan benjolan yang semakin membesar kemudian menjadi borok di pelipis kiri sejak satu tahun. Riwayat sering terpajan sinar matahari. Pada pemeriksaan fisik ditemukan ulkus dengan diameter 3 cm dan krusta. Temuan histopatologik menunjukkan sel ganas dengan inti hiperkromatik dan tepi palisade. Penatalaksanaan dengan bedah eksisi, flap rotasi dan skin graft. KSB jarang bermetastasis, namun dapat mendestruksi jaringan di dekatnya. Studi epidemiologi memberikan fakta bahwa patogenesis KSB dapat terjadi melalui efek imunologik dan karsinogenik. Gambaran histopatologik penting untuk menentukan varian KSB. Prognosis quo ad vitam bonam, ad sanam dubia ad bonam, ad kosmetikam dubia ad bonam.Kata kunci: Bedah eksisi, flap rotasi, karsinoma sel basal, skin graft

Background: Atopic dermatitis is a chronic and residive inflammatory skin disease with mild to severe itching and occurs mostly in infant and children. The cause not certainty known and multifactorial.Objective: This study aims to Know the Characteristics of Atopic Dermatitis in Puskesmas Masaran 1, Sragen Regency.Method: This study is descriptive with a retrospective cross-sectional design. Secondary data retrieved from medical records atopic dermatitis patients at Puskesmas Masaran 1 in the period 1 January-31 December 2019 with a sample 248 people then analyze using a computer program.Result: The most atopic dermatitis sufferers were the adult age group (151 people), female gender (139 people),  not working (96 people), atopic history disease found in 112 patients, site of the most lesions was lower extremities (71 patients), and the choice therapy is polytherapy with three types of drugs in 103 patients. Types of drugs are corticosteroids (224 patients), antihistamines (212 patients), and vitamins/minerals (200 patients).Conclusion: Characteristics of atopic dermatitis in Puskesmas Masaran 1 are the most age group is adults, gender is female, types of work is not working, atopic history is atopic dermatitis, and therapeutic options are corticosteroids, antihistamines, and vitamins/minerals.

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Background: For toddlers younger than 36 months, most of them still use diapers, so diaper rashes frequently appear in the diaper area. To improve the skin barrier, a moisturizer is needed to repair the skin barrier. Besides, the ceramide gold standard of moisturizer for diaper dermatitis, topical ingredients with natural ingredients can be used, for example, topical Aloe vera. Objective: To prove the effectiveness of topical Aloe vera moisturizer compared to other topical ingredients against diaper dermatitis. Methods: The results of the electronic database search Medline Pubmed, Scopus, EBSCOhost, ProQuest, Cochrane library, ClinicalTrials.gov, found 5 articles were included in the qualitative review (n = 289 subjects) and 4 articles (n = 214 subjects) were included in the meta-analysis. Results: Meta-analysis showed that after the administration of topical Aloe vera, there was a mean difference in the score of the degree of diaper dermatitis before and after therapy, the result showed negative value in the studies which were included the treatment group with Aloe vera. This indicates a decrease in the degree of diaper dermatitis after treatment with Aloe vera. The control group also showed that the mean score difference in the degree of diaper dermatitis after administration of control therapy was all negative. This shows that after the administration of therapy in the control group there was also a decrease in the score of the degree of dermatitis. The biggest decrease in the degree of diaper dermatitis was in the study conducted by Murni 2020, which was -2.10 ± 1.39. The lowest decrease in the degree of diaper dermatitis was found in the study conducted by Badelbuu 2019 B which received Chamomile, which was -0.93 ± 1.08. Meanwhile, in the Panahi’s study, the heterogeneity test results showed the value of Q=5,324 df=43; p=0,256, I2=24,866. This shows that the data is homogeneous, it is in line with the results of the statistical Q test and heterogeneity, the results of the I2 test obtained p < 0.001 which also indicates the data is homogeneous. The analysis was carried out using a fixed effect model because the data were homogeneous. The results of the meta-analysis showed that the statistical Q value was z value = -0.969 (p = 0.047). It has quite meaningful results. Conclusion: The meta-analysis showed that statistically there were only slight differences, but there were also studies that provided significant results. Topical application of Aloe vera appears to be more effective. The results of qualitative analysis on other skin barrier function parameters indicate that topical Aloe vera can improve skin barrier function in diaper dermatitis patients. In addition, it provides the same results as standard therapy and several other topical therapies that had been studied which had a good effect on repairing the skin barrier.

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