Stability of Zoledronate Gel Emulsion in Virgin Coconut Oil

Gayatri, Prima Abigail; Krisnawati,; Sahlan, Muhamad; Pratami, Diah Kartika; Widayati, Retno Indar

doi:10.22159/ijap.2019.v11s1.18204

Cited by 5 publications

(5 citation statements)

References 22 publications

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“…One of the topical preparations with a local effect is emulgel. 16 The bisphosphonate risedronate in this study was modified as an emulgel with VCO as the oil phase in its preparation. The results revealed that the effectiveness was not much different from previous studies, namely a decrease in the distance of the relapse movement.…”

Section: Discussionmentioning

confidence: 99%

The Effect Of Bisphosphonate Risedronate Emulgel On The Inhibition Of Relaps Tooth Movement

Utari,

Mirnacantika,

Zulfikar

et al. 2023

Odonto: Dental Journal

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Background: Orthodontic treatment is performed to correct the malocclusion, and after treatment is complete. The position of the teeth must be maintained because the teeth can move back to their original position, commonly known as relapse. Various attempts have been made, such as using retainers, and various studies have used pharmacological agents such as bisphosphonate risedronate to inhibit relapse, but these studies still used the injection method, which is inconvenient to apply and has a systemic effect. For this reason, changing the bisphosphonate preparation to an emulgel will facilitate its application and have a local effect, but it is necessary to test and determine its effectiveness in inhibiting the relapse. Method: An experimental laboratory study was conducted on 18 guinea pigs, which were divided into three groups: I (control), II (emulgel without risedronate), and III (emulgel with risedronate). The teeth were moved with open coil springs on both lower incisors for seven days, stabilized for seven days, and emulgel applied in groups II and III. The coil spring was removed, and the distance between the two incisors was measured on the third and seventh days. Result: Using One-Way ANOVA and Post Hoc LSD, the data analysis results showed significant differences between the control and the risedronate emulgel groups on the third and seventh days. The largest relapse occurred in the control group, while the smallest was in the emulgel group with risedronate. Conclusion: These results indicate that risedronate bisphosphonate in the form of emulgel influences inhibiting the movement of tooth relapse

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Section: Discussionmentioning

confidence: 99%

The Effect Of Bisphosphonate Risedronate Emulgel On The Inhibition Of Relaps Tooth Movement

Utari,

Mirnacantika,

Zulfikar

et al. 2023

Odonto: Dental Journal

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“…Modern researchers involved in topical semi-solid dosage forms quality assessment use a limited set of techniques to test the spreadability (various modifications of the parallel-plate method or the "slip and drag" method are most often used) [5][6][7][8][9][10][11][12][13][14][15]. In each same study, the conditions of the experiment are often subjected to significant or minor changes (parameters such as the exposure time of the load, the mass of the load, the mass of the dosage form, and the size of the glass plates).…”

Section: Discussionmentioning

confidence: 99%

“…A weight (50-500 g) of 125 g is placed on top for 1 minute. Then the diameter of the sample between the plates is measured [7][8][9][10][11].…”

Section: Parallel-plate Methodsmentioning

confidence: 99%

Dermatologic Gels Spreadability Measuring Methods Comparative Study

et al. 2022

Int J App Pharm

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Objective: The main objective of our study is the comprehensive analysis and characterization of the existing spreadability evaluation strategies, the comparison of the obtained results reproducibility and convergence through the example of the 9 most widely used dermatological gels. Methods: Dolobene®, Flucinar®, Ketorol®, Contractubex®, Dr. Theiss Venen gel®, Solcoseryl®, Deep Relief®, Hepatrombin® pharmacopoeia gel samples were analyzed using parallel-plate, “slip and drag”, and viscometry methods. Analysis was performed in flow mode at 32±0.2 °C, over shear rates ranging from 0 to 350 s−1, increasing over a period of 120 s, and was maintained at the superior limit for 10 s and then decreased during the same period. At least 5 replicates of each sample were evaluated, and the upward flow curves were fitted using the Casson mathematical model. Results: Solcoseryl® and Dolobene® showed the best spreadability in the parallel-plate method (3115.66±50.00 and 3316.63±50.00, respectively); Contractubex® and Dolobene showed the best spreadability in the “slip and drag” test (73.46±0.5 and 18.32±0.5, respectively); Solcoseryl® and Contractubex® showed the best spreadability in the viscometry test (43.86±0.5 and 76.92±0.5, respectively). Conclusion: This study analyzed the existing methods for determining the spreadability using commercially available samples of the dermatological gels as examples. The viscometric and the "Slip and drag" methods use different characteristics of spreadability, giving a complex evaluation of the measured parameter in vitro. Therefore, the combination of these two methods has the greatest prospects for reliable determination of this indicator.

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“…Deployment ability was measured by the slope of the distribution equation of the diameter of the dispersion versus weight load. [ 3 5 ]…”

Section: Methodsmentioning

confidence: 99%

Peel-off emulgel mask of Cocos nucifera L. Extract using gelling agent carbomer 940 as antiacne against Propionibacterium acnes ATCC 11827

Hariyadi

Isnaeni

Sisunandar

et al. 2020

J Adv Pharm Technol Res

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Stability of Zoledronate Gel Emulsion in Virgin Coconut Oil

Cited by 5 publications

References 22 publications

The Effect Of Bisphosphonate Risedronate Emulgel On The Inhibition Of Relaps Tooth Movement

The Effect Of Bisphosphonate Risedronate Emulgel On The Inhibition Of Relaps Tooth Movement

Dermatologic Gels Spreadability Measuring Methods Comparative Study

Peel-off emulgel mask of Cocos nucifera L. Extract using gelling agent carbomer 940 as antiacne against Propionibacterium acnes ATCC 11827

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