Label-free immunosensor based on micromachined bulk acoustic resonator for the detection of trace pesticide residues

Wang, Jingjing; Chen, Da; Xu, Yan; Liu, Weihui

doi:10.1016/j.snb.2013.08.102

Cited by 25 publications

(17 citation statements)

References 22 publications

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“…Immunoassay based on the antibody-hapten reaction has become a complementary method for the analysis of agrochemicals and pollutants because of their specificity, cost-effectiveness, and high sample throughput [127,128]. Technology of immunosensing is a rapid, versatile, and attractive mean for the on-site detection of small molecules (pesticides) in food and other environmental samples [129]. Various transduction systems, such as electrochemical, optical, piezoelectric, and nanomechanics methods have been reported in the literature for the fabrication of immunosensors for pesticide detection.…”

Section: Immunosensors For Pesticidesmentioning

confidence: 99%

Biosensor Technology for Pesticides—A review

Verma

Bhardwaj

2015

Appl Biochem Biotechnol

232

139

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Pesticides, due to their lucrative outcomes, are majorly implicated in agricultural fields for crop production enhancement. Due to their pest removal properties, pesticides of various classes have been designed to persist in the environment over a longer duration after their application to achieve maximum effectiveness. Apart from their recalcitrant structure and agricultural benefits, pesticides also impose acute toxicological effects onto the other various life forms. Their accumulation in the living system may prove to be detrimental if established in higher concentrations. Thus, their prompt and accurate analysis is a crucial matter of concern. Conventional techniques like chromatographic techniques (HPLC, GC, etc.) used for pesticides detection are associated with various limitations like stumpy sensitivity and efficiency, time consumption, laboriousity, requirement of expensive equipments and highly trained technicians, and many more. So there is a need to recruit the methods which can detect these neurotoxic compounds sensitively, selectively, rapidly, and easily in the field. Present work is a brief review of the pesticide effects, their current usage scenario, permissible limits in various food stuffs and 21st century advancements of biosensor technology for pesticide detection. Due to their exceptional performance capabilities, easiness in operation and on-site working, numerous biosensors have been developed for bio-monitoring of various environmental samples for pesticide evaluation immensely throughout the globe. Till date, based on sensing element (enzyme based, antibody based, etc.) and type of detection method used (Electrochemical, optical, and piezoelectric, etc.), a number of biosensors have been developed for pesticide detection. In present communication, authors have summarized 21st century's approaches of biosensor technology for pesticide detection such as enzyme-based biosensors, immunosensors, aptamers, molecularly imprinted polymers, and biochips technology. Also, the major technological advancements of nanotechnology in the field of biosensor technology are discussed. Various biosensors mentioned in manuscript are found to exhibit storage stability of biocomponent ranging from 30-60 days, detection limit of 10(-6) - 10(-16) M, response time of 1-20 min and applications of developed biosensors in environmental samples (water, food, vegetables, milk, and juice samples, etc.) are also discussed. Researchers all over the globe are working towards the development of different biosensing techniques based on contrast approaches for the detection of pesticides in various environmental samples.

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Section: Immunosensors For Pesticidesmentioning

confidence: 99%

Biosensor Technology for Pesticides—A review

Verma

Bhardwaj

2015

Appl Biochem Biotechnol

232

139

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“…These platforms are able to convert biological responses into electrical signals [ 1 , 2 ]. Great potential in biosensing application areas has been found not only for cantilever sensors [ 3 , 4 , 5 ], but also for film bulk acoustic resonators (FBAR) [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Periodical Microstructures Based on Novel Piezoelectric Material for Biomedical Applications

Janušas

Ponelyte

Brunius

et al. 2015

Sensors

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A novel cantilever type piezoelectric sensing element was developed. Cost-effective and simple fabrication design allows the use of this element for various applications in the areas of biomedicine, pharmacy, environmental analysis and biosensing. This paper proposes a novel piezoelectric composite material whose basic element is PZT and a sensing platform where this material was integrated. Results showed that a designed novel cantilever-type element is able to generate a voltage of up to 80 µV at 50 Hz frequency. To use this element for sensing purposes, a four micron periodical microstructure was imprinted. Silver nanoparticles were precipitated on the grating to increase the sensitivity of the designed element, i.e., Surface Plasmon Resonance (SPR) effect appears in the element. To tackle some issues (a lack of sensitivity, signal delays) the element must have certain electronic and optical properties. One possible solution, proposed in this paper, is a combination of piezoelectricity and SPR in a single element.

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“…The mass resolutions were achieved to zeptogram and nanogram when the nanomechanical resonators operated in vacuum and fluid environment, respectively (Arlett et al 2011). Recently, film bulk acoustic resonator (FBAR) has become another promising micro-electromechanical candidate as an alternative to QCM for the gas detection (Chen et al 2011b;Lu et al 2015) and bio-sensing applications (Pang et al 2012;Wang et al 2014). FBAR features a 1-2 micron-thick piezoelectric thin film, such as AlN (Wingqvist 2010), ZnO (Flewitt et al 2015), Pb(Zr,Ti)O 3 (Zinck et al 2005), Ba x Sr 1-x TiO 3 (Lee and Mortazawi 2016), and allows a significantly higher frequency and sensitivity than those of QCMs (Voiculescu and Nordin 2012).…”

Section: Introductionmentioning

confidence: 99%

Micro-electromechanical film bulk acoustic sensor for plasma and whole blood coagulation monitoring

Chen

Song

et al. 2017

Biosensors and Bioelectronics

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Monitoring blood coagulation is an important issue in the surgeries and the treatment of cardiovascular diseases. In this work, we reported a novel strategy for the blood coagulation monitoring based on a micro-electromechanical film bulk acoustic resonator. The resonator was excited by a lateral electric field and operated under the shear mode with a frequency of 1.9GHz. According to the apparent step-ladder curves of the frequency response to the change of blood viscoelasticity, the coagulation time (prothrombin time) and the coagulation kinetics were measured with the sample consumption of only 1μl. The procoagulant activity of thromboplastin and the anticoagulant effect of heparin on the blood coagulation process were illustrated exemplarily. The measured prothrombin times showed a good linear correlation with R=0.99969 and a consistency with the coefficient of variation less than 5% compared with the commercial coagulometer. The proposed film bulk acoustic sensor, which has the advantages of small size, light weight, low cost, simple operation and little sample consumption, is a promising device for miniaturized, online and automated analytical system for routine diagnostics of hemostatic status and personal health monitoring.

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Label-free immunosensor based on micromachined bulk acoustic resonator for the detection of trace pesticide residues

Cited by 25 publications

References 22 publications

Biosensor Technology for Pesticides—A review

Biosensor Technology for Pesticides—A review

Periodical Microstructures Based on Novel Piezoelectric Material for Biomedical Applications

Micro-electromechanical film bulk acoustic sensor for plasma and whole blood coagulation monitoring

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