Label-free immunosensor based on hyperbranched polyester for specific detection of α-fetoprotein

Nanomaterials for Healthcare Biosensing Applications

“…The OD 600 LOD was 0.025 and the linear response range was between 0.025 and 0.5. Niu and co-workers reported an immunosensor for the label-free detection of α fetoprotein (AFP) using hyperbranched polyester with nitrite end groups in conjugation with a chitosan–AuNP functionalised GCE [266]. The modified electrode was then used as a surface for AFP antibody immobilisation and the free sites on the surface were blocked with BSA.…”

Antibody mounting capability of 1D/2D carbonaceous nanomaterials toward rapid-specific detection of SARS-CoV-2

“…What is more, the specification of sensing interfaces as core parts of label-free immunosensors holds a great level of importance. Therefore, these interfaces had better be accompanied by a wide active surface area and excellent electrical conductivity of a proper nanostructure to improve the quality of the output signal [ [18] , [19] , [20] ]. Hence, carbonaceous nanomaterials such as graphene derivatives and carbon nanotubes (CNTs) could be considered as potential candidates to address this crucial demand because of their extraordinary properties [ 17 , [21] , [22] , [23] , [24] ].…”

Hyperbranched poly(ester ether)s as an amplified fluorescence sensor for selective and sensitive Fe3+ detection and bioimaging

“…Fluorescent chromophore-free hyperbranched polymers have shown great potential as chemosensors in identifying specific biological analytes, such as thrombin, α-fetoprotein, and metal ions. 11,23,29,30 Iron is one of the most essential elements in biological systems and plays a crucial role in all biological organisms. [31][32][33] However, both deficiency and excess of iron in the body will lead to detrimental effects, such as anemia, poor immunity, hemochromatosis, Parkinson's disease, and dysfunction of liver or heart.…”