Kronik Hepatit B Enfeksiyonu Olan Hastalarda HBsAg ve HBeAg Değerlerinin HBV DNA ve Alanin Aminotransferaz Düzeyleri ile Karşılaştırılması

Sağlık, İmran; Mutlu, Derya; Öngüt, Gözde; Akbaş, Halide; Güvenç, Hülya İren; Öğünç, Dilara; Çolak, Dilek

doi:10.4274/vhd.84856

Cited by 2 publications

(4 citation statements)

References 19 publications

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“…Ülkemizde yapılan çalışmalarda da, KHB hastalarında HBsAg seviyelerinin HBV DNA ile korelasyon gösterdiği (14)(15)(16) , kantitatif HBsAg ölçümün peg-interferon tedavisinin etkinliğini izlemede HBV DNA ile yer değişebileceği (14) ve inaktif ve aktif taşıyıcıları ayırmada kullanılabileceği (16) bildirmiştir. KHB'li çocuk hastalarda yapılan bir çalışmada da, tedavi sırasında HBsAg, HBeAg, HBV DNA ve ALT seviyelerinin belirgin biçimde düştüğü ve kantitatif HBsAg testlerinin KHB tedavisinin takibinde oldukça önemli role sahip olduğu belirtilmiştir (17) .…”

Section: Discussionunclassified

Quantitative determination of HBsAg levels in chronically infected patients with hepatitis B virus

Ülger¹,

Delıalıoğlu²,

Kandemir³

et al. 2018

TMCD

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Kronik hepatit B (KHB) enfeksiyonunun tanı ve izlenmesinde serum HBV DNA düzeyi virus replikasyonunun en yaygın göstergesi olup, serolojik belirteçler ve alanin aminotransferaz (ALT) düzeyinin ölçümü ile birlikte yaygınlıkla kullanılmaktadır. Son yıllarda ise, kantitatif HBsAg düzeyleri ile HBV DNA ve ALT düzeylerinin ilişkili olduğu gösterilmiştir. Bu çalışmada, KHB hastalarında kantitatif HBsAg seviyelerinin HBV DNA, ALT-AST seviyeleri ve HBeAg ile karşılaştırılarak incelenmesi amaçlanmıştır.

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Section: Discussionunclassified

Quantitative determination of HBsAg levels in chronically infected patients with hepatitis B virus

Ülger¹,

Delıalıoğlu²,

Kandemir³

et al. 2018

TMCD

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“…A great deal of studies has found a positive relationship between HBsAg and HBV DNA levels. However, there are also studies in which no relationship has been established or a negative relationship has been established [13]. Although HBsAg is positive; (In the nonreplicative period after the infection's immunoreaction phase), HBV DNA can be detected negative, which is an indicator of active viral replication.…”

Section: Discussionmentioning

confidence: 99%

“…In our country; Külah et al [12] 53%, Sağlık et al [13] 92%, Otlu et al [14] 71% and Koçoğlu et al [15] 45% reported HBV DNA positivity in HBsAg positive patients, respectively. Eroğlu et al [16] was compared HBV DNA detection with PCR and hybridization methods; HBV DNA positivity was detected 36% by PCR, and 32% by hybrid capture method.…”

Section: Discussionmentioning

confidence: 99%

“…Also, HBV DNA can be detected negative in treated cases which in asymptomatic or healthy hepatitis B carriers (29). In studies which made in HBsAg positive patients reported HBV DNA negativity; Külah et al [12] as 47%, Sağlık et al [13] as 8%, Otlu et al [14] as 29%, Koçoğlu et al [15] as 55%, Peignoux et al [17]as 14%, Odaibo et al [18] as 18%, Hasan et al [19] as 55.2% and Poljak et al [20] as 31%, respectively. Similarly in other studies, in our study we found HBV DNA negativity 57.5% in HBsAg positive cases.…”

Section: Discussionmentioning

confidence: 99%

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Investigation of HBV DNA in HBsAg positive patients

Bati¹,

Tekerekoğlu²,

Duman³

2017

Med-Science

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Hepatitis B virus is an important health problem which about 400 million people are infected chronically and 500,000 to 1,200,000 people die every year due to HBVrelated diseases. In the study we aimed to investigate the HBV DNA results in HBsAg positive patients. HBsAg positivity was detected by ELISA method in patients who were admitted to our hospital with suspicion of hepatitis. HBV DNA was performed by real time PCR. In this context, the presence of HBV DNA in serum sample results of 2437 HBsAg-positive patients which were sent to our Microbiology laboratory between August 2014 and August 2015 was retrospectively examined. HBV DNA was positive in 1037 (42.5%) and 1400 (57.5%) of the HBsAg positive cases. 42.2% of male patients' and 43% of female patients' HBV DNA was positive. HBV DNA positivity was detected in 42% of adult patients and 55% of children in child age group. As a result; we suggest that viral replication should be demonstrated in HBsAgpositive cases and HBV DNA level should be determined for follow-up the antiviral therapy.

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Kronik Hepatit B Enfeksiyonu Olan Hastalarda HBsAg ve HBeAg Değerlerinin HBV DNA ve Alanin Aminotransferaz Düzeyleri ile Karşılaştırılması

Cited by 2 publications

References 19 publications

Quantitative determination of HBsAg levels in chronically infected patients with hepatitis B virus

Quantitative determination of HBsAg levels in chronically infected patients with hepatitis B virus

Investigation of HBV DNA in HBsAg positive patients

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