Quantitative determination of HBsAg levels in chronically infected patients with hepatitis B virus

Ülger, Seda Tezcan; Delıalıoğlu, Nuran; Kandemir, Özlem; Celikcan, Havva Didem

doi:10.5222/tmcd.2018.060

Cited by 1 publication

(1 citation statement)

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“…In a limited number of population studies, it has been shown that qHBsAg measurement correlates with HBV DNA and may be a suitable marker for monitoring the effectiveness of HBV treatment [16] .Studies with a larger number of patients, it has been shown that the qHBsAg level could be used to differentiate inactive and active hepatitis B patientsandsince the use of qHBsAg tests are less costly in laboratories where molecular tests cannot be applied, it has been suggested as a more appropriate approach in CHB treatment monitoring [17,18] . In the present study, a negative correlation was determined between qHBsAg and HBV DNA levels and a significant positive correlation between HBeAg positivity and qHBsAg level.…”

Section: Discussionmentioning

confidence: 99%

The Analysis of the Correlations between Quantitative HBsAG Level, Virological Markers, and Histopathological Findings in Patients with Chronic Hepatitis B

Deveci,

Mermutluoğlu,

Cerrah

et al. 2023

ijmsci

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Introduction: We aimedto analyze the correlations between serum HBsAg quantification (qHBsAg) level and virological properties in chronic hepatitis B (CHB) patients. Materials and Methods: The study was conducted with 53 CHB patients who underwent liver biopsy. Demographic characteristics of patients, biochemical parameters, serum qHBsAg levels, liver biopsy, and histopathology were assessed retrospectively. Results: A total of 53 patients were included in the study the mean patient age was 28,7 ± 8.1 and 34 (64.2%) were male. The mean patient qHBsAg was 631.4 ± 431.5, fibrosis score was 1,35 ± 0.87, ALT index score was 67.1 ± 53.4, and histologic activity index (HAI) score was 4,54 ± 1.55. In the statistical analysis, it was determined that there were negative correlations between the serum qHBsAg level and the HBV DNA level (r: -0,618, P<0.001), fibrosis score (r: -0,273, P: 0.048), ALT (rho: -0,489, P<0.001), and HAI index scores (r: -363, P: 0.008), while there was a positive correlation with the HBeAg positivity (rho: 0.445, p: 0.001). Conclusion: There were negative correlations between the qHBsAg level and virological (HBV DNA level), histopathological (fibrosis score, HAI index) findings, and a positive correlation with serological (HBeAg positivity) findings.

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Section: Discussionmentioning

confidence: 99%