Kounis syndrome secondary to amoxicillin/clavulanic acid administration: a case report and review of literature

Ralapanawa, Dissanayake Mudiyanselage Priyantha Udaya Kumara; Kularatne, S.A.M.

doi:10.1186/s13104-015-1072-5

Cited by 20 publications

(13 citation statements)

References 9 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other than cutaneous type of reaction, amoxicillin causes various other ADRs such as acute generalized pustulosis, agranulocytosis, pancreatitis and Kuoni's syndrome. [17][18][19][20] The practice of reporting ADRs to WHO Uppsala Monitoring centre helps make more decision on framing usage guidelines for drugs. In India the pharmacovigilance program of India (PvPI) receiving the ADR reports from various regional PvPI centers and reporting to WHO centre.…”

Section: Discussionmentioning

confidence: 99%

Amoxicillin induced erythematous maculopapular rashes: a case report

Kumar¹,

Rajganesh²,

Shree³

et al. 2020

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

Cutaneous adverse reactions (CAR) can occur with any class of drugs, however more widely caused by various antibiotics. Amoxicillin is a broad-spectrum, bactericidal, beta-lactam antibiotic, widely used for combating various infections. Cutaneous drug eruptions are known to be reported common while using penicillin class of drugs, specifically among children. These immune-mediated bizarre drug eruptions were range from mild to severe drug-induced cutaneous reactions, such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). The present case reported with maculopapular, erythematous rashes induced by amoxicillin in a nine-year-old male patient. Amoxicillin was prescribed for his hyperactive respiratory disease and subsequently after three days developed generalized maculopapular erythematous rashes as a result of an antibiotic-induced skin rash. The present case is being reported to add more data, also to emphasize and gather the information for evidence-based practice and to promote efficient pharmacovigilance adverse drug reaction reporting.

show abstract

Section: Discussionmentioning

confidence: 99%

Amoxicillin induced erythematous maculopapular rashes: a case report

Kumar¹,

Rajganesh²,

Shree³

et al. 2020

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

show abstract

“…However, we believe that definite differentiation of this vasospasm from the Kounis Syndrome is a challenge. The Kounis syndrome is defined as temporary vasospasm of coronary vessels due to histamine release after exposure to allergens . It is known that food allergy is one of the factors triggering this syndrome .…”

Section: Discussionmentioning

confidence: 99%

Investigation of Toxic Effects of Mushroom Poisoning on the Cardiovascular System

Erenler

Doğan

Koçak

et al. 2016

Basic Clin Pharma Tox

View full text Add to dashboard Cite

Mushroom poisoning (MP) is a public health problem in many countries. It is well known that consumption of wild mushrooms may cause serious toxicity on renal, hepatic and brain functions. In the literature, however, studies investigating cardiotoxic effects of MP are rare. In this study, we evaluated laboratory and ECG findings of patients and sought for possible toxic effects of MP on the cardiovascular system. During a 2-year period, 175 patients with MP were included in the study. The majority of the poisonings occurred in early summertime. The most common complaint was found to be nausea and vomiting followed by mental status alterations. Methods of treatment were mainly based on gastric lavage, activated charcoal and supportive therapy. The most common ECG abnormalities in the patients with MP were sinus tachycardia, sinus arrhythmia, ST/T inversion, 1st degree AV block and QT prolongation, respectively. Cardiac markers of the patients were found to be normal. Then, patients were divided into two subgroups according to symptom onset after consumption (less than 6 hr and more than 6 hr). When the two groups were compared, prevalence of tachycardia was significantly higher in Group II. Additionally, the interval between mushroom consumption and onset of symptoms was strongly correlated with blood pressure (BP). As this interval prolonged, BP of the patients tended to increase. In conclusion, according to our results, although mechanisms need to be clarified, MP causes hypertension and ECG alterations, particularly tachycardia in patients with late-onset symptoms.

show abstract

“…58 However, there are several reports about AMX-CA's different side effects, such as the presence of Kounis syndrome, neurotoxic manifestations, toxicity in the liver, and induction of pancreatitis. [59][60][61][62]…”

Section: Amx/clavulanic Acid (Ca)mentioning

confidence: 99%

Prevention of infective endocarditis and bacterial resistance to antibiotics: A brief review

Loyola-Rodríguez

Miranda

Loyola-Leyva

et al. 2019

Special Care in Dentistry

View full text Add to dashboard Cite

The purpose of this statement is to debate the recommendations of the American Heart Association (AHA) for the prevention of infective endocarditis through an antibiotic prophylaxis protocol and its relation with bacterial resistance to antibiotics. Since dental infections involve biofilms that include several bacterial species (Gram‐negative and Gram‐positive), it is essential, from the dental point of view, to consider the frequency, magnitude, and duration of bacteremia associated with active dental infections before applying antibiotic prophylaxis. The actual guidelines for antibiotic prophylaxis should be revised according to recent evidence of bacterial resistance. Amoxicillin/clavulanic acid and moxifloxacin should be considered due to their effectiveness against bacteria associated with oral, GU, and GI infections and the low rates of antibiotic resistance associated with these antibiotics, instead of the actual protocol, which includes amoxicillin (2 g) or clindamycin (600 mg) administered an hour before the dental procedures. The breaking point to test the antibiotic bacterial resistance (ABR) had a wide range in the different studies that were analyzed, which could explain the widely varied ABR percentages reported for the various antibiotics used for antibiotic prophylaxis.

show abstract

Kounis syndrome secondary to amoxicillin/clavulanic acid administration: a case report and review of literature

Cited by 20 publications

References 9 publications

Amoxicillin induced erythematous maculopapular rashes: a case report

Amoxicillin induced erythematous maculopapular rashes: a case report

Investigation of Toxic Effects of Mushroom Poisoning on the Cardiovascular System

Prevention of infective endocarditis and bacterial resistance to antibiotics: A brief review

Contact Info

Product

Resources

About