Juçara (<i>Euterpe edulis</i> Mart.) Supplementation Reduces Aberrant Crypt Foci and Increases SOD1 Expression in the Colorectal Mucosa of Carcinogenesis-Induced Rats

Reis, Schalana Oliveira dos; Luz, Tamires Conceição da; Couto, Cinthia Vidal Monteiro da Silva; Dalbó, Juliana; Nunes, Louisiane de Carvalho; Martins, Marina Carvalho; Silva, Pollyanna Ibrahim; Silva, Adriana Madeira Alvares da; Trivilin, Leonardo Oliveira

doi:10.1080/01635581.2019.1649437

Cited by 12 publications

(6 citation statements)

References 43 publications

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“…Further, free radicals induce the production of angiogenic factors that favor tumor growth and metastasis ( 35 ). Dos Reis et al ( 8 ) showed that including the juçara fruit in the diet of carcinogen-induced mice decreased the number of aberrant crypts in the colon and rectum and increased SOD1 protein expression, thereby conferring protection to the colonic mucosa, which demonstrated the ability of phenolic compounds to reduce oxidative stress. Thus, the under-expression of SOD1 observed in this study could be potentially due to the ability of compounds present in the juçara fruit to control oxidative stress without the need for induction of antioxidant enzymes, as shown by the low expression of NRF2 .…”

Section: Discussionmentioning

confidence: 99%

“…The juçara fruit ( Euterpe edulis Martius) stands out as a rich source of antioxidant compounds like anthocyanins, which can regulate the expression of cytoprotective genes such as SOD1 and GPx ( 8 ). Therefore, we examined the effects of the juçara fruit pulp and lyophilized extract on the expression of cytoprotective genes NRF2 , KEAP1 , SOD1 , and GPX2 in human CRC cell lines.…”

Section: Introductionmentioning

confidence: 99%

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Effects of the juçara fruit (Euterpe edulis Martius) pulp and lyophilized extract on NRF2, KEAP1, SOD1, and GPX2 expression in human colorectal cancer cell lines

Milholli

Dalbó

Couto

et al. 2023

Braz J Med Biol Res

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We investigated the effects of the juçara fruit ( Euterpe edulis Martius) pulp and lyophilized extract on the expression of cytoprotective genes nuclear factor erythroid 2 (NF-E2)-related factor 2 ( NRF2 ), kelch-like ECH-associated protein 1 ( KEAP1 ), superoxide dismutase ( SOD1 ), and glutathione peroxidase ( GPX2 ) in human colorectal cancer cell lines (HT-29 and Caco-2). Cells were cultured for 24 h in Dulbecco's Modified Eagle's Medium containing juçara fruit pulp (5, 10, or 50 mg/mL) or lyophilized extract (0.05, 0.1, or 0.5 mg/mL), and gene expression was quantified using real-time quantitative reverse transcription polymerase chain reaction. All studied genes showed significant variation in gene expression among different concentrations of pulp or lyophilized extract. Overall, the expression of the selected genes decreased in both cell lines following exposure to the pulp or lyophilized extract in a dose-dependent manner for most of the concentrations studied. In summary, our study showed that the compounds in juçara fruit inhibited the expression of cytoprotective genes associated with the antioxidant response and that, although not cytotoxic at the concentrations studied, they could potentially block the activation of the NRF2/KEAP1 pathway.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of the juçara fruit (Euterpe edulis Martius) pulp and lyophilized extract on NRF2, KEAP1, SOD1, and GPX2 expression in human colorectal cancer cell lines

Milholli

Dalbó

Couto

et al. 2023

Braz J Med Biol Res

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“…Secondary metabolites contribute to the chemical complexity of plants and are associated with their biological activities. The pharmacological potential of these plants, based on their phytochemical compounds, can aid in restoring the body's redox balance [27] and chronic conditions [28,29]. Some metabolites that have biological effects related to the context of obesity and its complications are tannins [30,31], coumarins [32,33], terpenoids [34], anthocyanins [35,36], saponins [37], phenolic compounds, and flavonoids [38].…”

Section: Chemical Constitution Of Native Plants Of the Brazilian Cerradomentioning

confidence: 99%

New Therapeutic Strategies for Obesity and Its Metabolic Sequelae: Brazilian Cerrado as a Unique Biome

Monteiro-Alfredo,

Macedo,

de Picoli Souza

et al. 2023

IJMS

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Brazil has several important biomes holding impressive fauna and flora biodiversity. Cerrado being one of the richest ones and a significant area in the search for new plant-based products, such as foods, cosmetics, and medicines. The therapeutic potential of Cerrado plants has been described by several studies associating ethnopharmacological knowledge with phytochemical compounds and therapeutic effects. Based on this wide range of options, the Brazilian population has been using these medicinal plants (MP) for centuries for the treatment of various health conditions. Among these, we highlight metabolic diseases, namely obesity and its metabolic alterations from metabolic syndrome to later stages such as type 2 diabetes (T2D). Several studies have shown that adipose tissue (AT) dysfunction leads to proinflammatory cytokine secretion and impaired free fatty acid (FFA) oxidation and oxidative status, creating the basis for insulin resistance and glucose dysmetabolism. In this scenario, the great Brazilian biodiversity and a wide variety of phytochemical compounds make it an important candidate for the identification of pharmacological strategies for the treatment of these conditions. This review aimed to analyze and summarize the current literature on plants from the Brazilian Cerrado that have therapeutic activity against obesity and its metabolic conditions, reducing inflammation and oxidative stress.

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“…Juçara pulp was used in most studies (83%) in lyophilized form mixed in standardized rations [10][11][12][13][14][15][18][19][20][22][23][24][25][26][27]. The other studies (17%) used an aqueous extract obtained by diluting the pulp in water in proportions of 1:2 or 1:3, with one part pulp for two or three parts water administered via gavage [17,21]. The concentrations ranged from 0.25% to 10% and 22.5 mg/kg to 5 g/kg.…”

Section: Experimental Studiesmentioning

confidence: 99%

“…Supplementation with juçara was also able to reduce preneoplastic colorectal lesions [17], offer protection in the case of induced peptic ulcers [21], provide renal protection [13,18,25], and prevent degeneration and mutagenicity of liver tissue and cells [9,24].…”

Section: Experimental Studiesmentioning

confidence: 99%

Effects of Juçara (Euterpe edulis Martius) on Health: An Overview of Clinical and Experimental Studies and Call for Action

Siqueira

Lopes

et al. 2023

Nutrients

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Background and aims: Juçara is a fruit of ecological and nutritional importance. Its fruits represent an option for the sustainable use of the plant due to its vulnerability to extinction. Thus, the aim of this review was to analyze clinical and experimental studies and highlight the literature gaps regarding the effects of supplementation with Juçara on health. Methods: For this scoping review, we consulted the Medline (PubMed), Science Direct, and Scopus databases in March, April, and May 2022. Experimental studies and clinical trials published in the last ten years (2012–2022) were analyzed. Data were synthesized and reported. Results: A total of 27 studies were included, 18 of which were experimental studies. Of these, 33% evaluated inflammatory markers associated with fat accumulation. Most of these studies (83%) used pulp in lyophilized form, and the others (17%) involved juçara extract mixed in water. In addition, 78% of the studies showed positive results with respect to the lipid profile, reduction of oncological lesions, inflammation, microbiota modulation, and improvement in obesity and glycemia-related metabolic complications. Nine clinical trials with results similar to those of experimental trials were found. The majority (56%) were chronic (four to six weeks into the intervention), and 44% were acute. Three offered juçara supplementation in the form of juice, four used freeze-dried pulp, two used fresh pulp, and one used a 9% dilution. The dose was fixed at 5 g, but the dilution ranged from 200 to 450 mL. These trials assessed mainly healthy, physically active, and obese individual adults (19–56 years old), and cardioprotective and anti-inflammatory effects, as well as improvement in the lipid profile and prebiotic potential, were observed. Conclusion: Juçara supplementation showed promising results with respect to its effect on health. However, further studies are needed to clarify these possible effects on health and their mechanisms of action.

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Juçara (Euterpe edulis Mart.) Supplementation Reduces Aberrant Crypt Foci and Increases SOD1 Expression in the Colorectal Mucosa of Carcinogenesis-Induced Rats

Cited by 12 publications

References 43 publications

Effects of the juçara fruit (Euterpe edulis Martius) pulp and lyophilized extract on NRF2, KEAP1, SOD1, and GPX2 expression in human colorectal cancer cell lines

Effects of the juçara fruit (Euterpe edulis Martius) pulp and lyophilized extract on NRF2, KEAP1, SOD1, and GPX2 expression in human colorectal cancer cell lines

New Therapeutic Strategies for Obesity and Its Metabolic Sequelae: Brazilian Cerrado as a Unique Biome

Effects of Juçara (Euterpe edulis Martius) on Health: An Overview of Clinical and Experimental Studies and Call for Action

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