Jet gun or syringe? A trial of alternative methods of BCG vaccination

Parker, Vivienne

doi:10.1016/s0033-3506(84)80023-2

Cited by 10 publications

(2 citation statements)

References 11 publications

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“…MUNJI devices provided millions of ID smallpox doses during the implementation of the smallpox eradication program (Millar and Foege 1969;Weniger and Papania 2008). Jet injectors have also been utilized historically for ID vaccination of rabies (Bernard et al 1982;Bernard et al 1987), hepatitis A (Williams et al 2000), BCG (Paul et al 1978;Parker 1984), DTP combination vaccine (Stanfield et al 1972), measles (Burland 1969;Kok et al 1983), and influenza vaccine (Weniger and Papania 2008).…”

Section: Historymentioning

confidence: 99%

Delivery Systems for Intradermal Vaccination

Kim

Jarrahian

Zehrung

et al. 2011

Current Topics in Microbiology and Immunology

114

107

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The skin is known to be a highly immunogenic site for vaccination, but few vaccines in clinical use target skin largely because conventional intradermal injection is difficult and unreliable to perform. Now, a number of new or newly adapted delivery technologies have been shown to administer vaccine to the skin either by non-invasive or minimally invasive methods. Non-invasive methods include high-velocity powder and liquid jet injection, as well as diffusion-based patches in combination with skin abrasion, thermal ablation, ultrasound, electroporation, and chemical enhancers. Minimally invasive methods are generally based on small needles, including solid microneedle patches, hollow microneedle injections and tattoo guns. The introduction of these advanced delivery technologies can make the skin a site for simple, reliable vaccination that increases vaccine immunogenicity and offers logistical advantages to improve the speed and coverage of vaccination.

show abstract

Section: Historymentioning

confidence: 99%

Delivery Systems for Intradermal Vaccination

Kim

Jarrahian

Zehrung

et al. 2011

Current Topics in Microbiology and Immunology

114

107

View full text Add to dashboard Cite

show abstract

“…It can be used to deliver a jet of liquid or particulate vaccines [163]. Jet injection of liquid vaccine was tested for smallpox vaccination [164] and has also been tested for measles, BCG and influenza [165][166][167][168]. In principle, nucleic acid-based vaccines can be delivered by first coating them onto gold particles and propelling them into the skin using this approach [163].…”

Section: Transdermalmentioning

confidence: 99%

Novel approaches for the design, delivery and administration of vaccine technologies

Wallis

Shenton

Carlisle

2019

Clinical and Experimental Immunology

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Summary It is easy to argue that vaccine development represents humankind’s most important and successful endeavour, such is the impact that vaccination has had on human morbidity and mortality over the last 200 years. During this time the original method of Jenner and Pasteur, i.e. that of injecting live‐attenuated or inactivated pathogens, has been developed and supplemented with a wide range of alternative approaches which are now in clinical use or under development. These next‐generation technologies have been designed to produce a vaccine that has the effectiveness of the original live‐attenuated and inactivated vaccines, but without the associated risks and limitations. Indeed, the method of development has undoubtedly moved away from Pasteur’s three Is paradigm (isolate, inactivate, inject) towards an approach of rational design, made possible by improved knowledge of the pathogen–host interaction and the mechanisms of the immune system. These novel vaccines have explored methods for targeted delivery of antigenic material, as well as for the control of release profiles, so that dosing regimens can be matched to the time‐lines of immune system stimulation and the realities of health‐care delivery in dispersed populations. The methods by which vaccines are administered are also the subject of intense research in the hope that needle and syringe dosing, with all its associated issues regarding risk of injury, cross‐infection and patient compliance, can be replaced. This review provides a detailed overview of new vaccine vectors as well as information pertaining to the novel delivery platforms under development.

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Skin Vaccination Methods: Gene Gun, Jet Injector, Tattoo Vaccine, and Microneedle

Kim

2017

Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement

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Jet gun or syringe? A trial of alternative methods of BCG vaccination

Cited by 10 publications

References 11 publications

Delivery Systems for Intradermal Vaccination

Delivery Systems for Intradermal Vaccination

Novel approaches for the design, delivery and administration of vaccine technologies

Skin Vaccination Methods: Gene Gun, Jet Injector, Tattoo Vaccine, and Microneedle

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