Ivermection-loaded solid lipid nanoparticles: preparation, characterisation, stability and transdermal behaviour

Abstract

To avoid potential systematical toxicity, solid lipid nanoparticles (SLNs) were prepared as a vehicle for transdermal delivery of ivermectin (IVM) using hot homogenisation followed by ultrasonic method. The as-prepared SLNs were approximately spherical shape with good stability. IVM was encapsulated in amorphous form within SLNs and displayed prolonged release from SLNs without burst release due to high encapsulation efficiency (EE). The cumulative permeation of IVM across excised rat skin from SLNs was significantly increased compared to the ivermection suspension. These results indicated that the proposed SLNs can be considered as an efficient carrier for dermal delivery of IVM to effectively treat scabies.

Development and characterization of polymeric-based nanoparticles for sustained release of amoxicillin – an antimicrobial drug

“…Likewise, Patil and Devarajan [38] also attributed negative surface charge of the prepared insulin-loaded alginate nanoparticles to the carboxyl groups in the polymer. The surface charge of nanoparticles with less than À30 mV or greater than 30 mV are related to the lower aggregation tendency of particles and higher stability in suspension [39,40].…”

Nanomedicine strategies to target coronavirus

“…Due to variety of different nanocarriers available and the possibility to tune these to fit the drug load as well as the target, most of the aforementioned drug candidates against CoV can be included into nanocarriers to target the lung, prevent early degradation or clearance as well as avert side effects [ 167 ]. In fact, different studies of drug-loaded nanocarriers have been reported in the past, involving CQ-loaded SLNs to treat CQ-resistance malaria [ 150 ], Tenofovir-loaded PLGA NPs to induce long- acting prevention of HIV vaginal transmission [ 168 ] or Ivermectin-loaded SLNs to facilitate transdermal delivery for the treatment of scabies [ 169 ]. Similarly different nanocarriers have been evaluated for the delivery of antibodies [ 170 , 171 ].…”

Synthesis of Tilmicosin Nanostructured Lipid Carriers for Improved Oral Delivery in Broilers: Physiochemical Characterization and Cellular Permeation

“…In order to evaluate the effect of solid lipids on the intestinal absorption of tilmicosin, palmitic acid (PA), lauric acid (LA), and stearic acid (SA) were employed as solid lipids, and mixed with oleic acid to prepare the various types of NLCs, which were TMS-pNLCs, TMS-lNLCs, and TMS-sNLCs, respectively. Particle size is considered as the fundamental index for the recognition of nanoparticles and plays an important role in the evaluation of nanoparticles [19]. Therefore, the hydrodynamic diameters (HDs) of NLCs were firstly measured by dynamic light scattering via Zetasizer Nano ZS, and the results showed they had a similar diameter and narrow size distribution, at 283.5 ± 3.53 nm, 277.5 ± 4.52 nm, and 289.5 + 5.06 nm, respectively ( Figure 1A).…”

“…Tilmicosin-loaded nanostructured lipid carriers (TMS-NLCs) were fabricated using high-shear followed by an ultrasonication process according to our previous report, with some minor modifications [19]. Briefly, the specific amounts of TMS, Tween 20, and oleic acid were blended with melted palmitic acid, lauric acid, or stearic acid, respectively, to acquire an oil phase under stirring at 12,000 rpm at 70 • C. In addition, poloxamer-407 was dissolved in the double-distilled water at the same temperature to obtain the aqueous phase.…”