Development and characterization of polymeric-based nanoparticles for sustained release of amoxicillin – an antimicrobial drug

Abstract

In this study, amoxicillin (AMO)-loaded poly(vinyl alcohol)/sodium alginate (PVA/NaAlg) nanoparticles were prepared as a polymer-based controlled release system. The physicochemical properties of the obtained nanoparticles were investigated by XRD, DSC/TGA, particle size analyses and zeta potential measurements. The average particle sizes were in the range from 336.3 ± 25.66 to 558.3 ± 31.39 nm with negative zeta potential values from -41.86 ± 0.55 to -47.3 ± 2.76 mV. The influences of PVA/NaAlg ratio, span 80 concentration, exposure time to glutaraldehyde (GA) and the drug/polymer ratio on AMO release profiles were evaluated. In vitro drug release studies showed a controlled and pH dependent AMO release with an initial burst effect. XRD patterns and DSC thermograms of AMO-loaded nanoparticles revealed that the drug in the nanoparticles was in amorphous form, which was more stable than the crystalline form. The antibacterial activity of the optimal formulation was also investigated. The minimum inhibitory concentration (MIC) values of this formulation had the comparable antibacterial activity with that of pure AMO. These results indicate that the developed nanoparticles could be a promising candidate drug delivery system for AMO.

Synthesis and Characterization of Antibiotic–Loaded Biodegradable Citrate Functionalized Mesoporous Hydroxyapatite Nanocarriers as an Alternative Treatment for Bone Infections

“…The prominent peaks of amoxicillin at 1772.54 cm −1 , 1680.21 cm −1 , and 1587.45 cm −1 can be seen in sole spectra of AMX and AMX loaded Ctr–mpHANCs [ 20 ]. This also endorses the loading of the drug in prepared formulations of AMX@Ctr–mpHANCs [ 34 ].…”

Poly(δ-valerolactone)/Poly(ethylene-co-vinylalcohol)/β-Tricalcium Phosphate Composite as Scaffolds: Preparation, Properties, and In Vitro Amoxicillin Release

“…The second step was much longer (151–153 h) and slower, in which between 25 and 48 wt% of AMOX was released depending on the percentage of β-TCP in the polymer matrix. Such behavior, usually observed by different authors in the drug delivery domain [ 71 ], can probably be attributed to both sides of the specimen’s leaching. A large number of drug particles attach or lightly embed on the surface and are immediately dissolved in the media.…”

α-Mangostin Nanoparticles Cytotoxicity and Cell Death Modalities in Breast Cancer Cell Lines

“…(b) Adding excipients with high water solubility increases drug solubility through hydrogen bond interactions between excipients and water molecules [ 105 , 122 , 123 ]. NPs can be applied to controlled release, delayed-release, and continuous release systems [ 124 , 125 ]. The type of NP and the materials are adapted to the purpose and intended use [ 27 , 126 , 127 ].…”