Itch in Scabies—What Do We Know?

Ständer, Sascha; Ständer, Sonja

doi:10.3389/fmed.2021.628392

Cited by 14 publications

(25 citation statements)

References 55 publications

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“…The development of the immune response corresponds to the time frame needed to develop symptoms. Mite antigens and components directly activates both the innate immune response via Toll-like receptors (TRLs) and pruriceptors (PAR-2, TRPV1, and TRPA1) [51,52]. The initial T cell response is mixed with both Th1 and Th2 components with a marked Th2 skewing, which is much more striking in crusted scabies, compared to ordinary scabies [49,50].…”

Section: Scabiesmentioning

confidence: 99%

Pruritus as a Distinctive Feature of Type 2 Inflammation

et al. 2021

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Pruritus is a common symptom of several skin diseases, both inflammatory and neoplastic. Pruritus might have a tremendous impact on patients’ quality of life and strongly interfere with sleep, social, and work activities. We review the role of type-2 inflammation and immunity in the pathogenesis of chronic pruritic conditions of the skin. Type 2 cytokines, including IL-4, IL-13, thymic stromal lymphopoietin, periostin, IL-31, IL-25, and IL-33 are released by mast cells, innate lymphoid cells 2, keratinocytes, and type 2 T lymphocytes, and are master regulators of chronic itch. These cytokines might act as direct pruritogen on primary sensory neurons (pruriceptors) or alter the sensitivity to other itch mediators Type 2 inflammation- and immunity-dominated skin diseases, including atopic dermatitis, prurigo nodularis, bullous pemphigoid, scabies, parasitic diseases, urticaria, and Sézary syndrome are indeed conditions associated with most severe pruritus. In contrast, in other skin diseases, such as scleroderma, lupus erythematosus, hidradenitis suppurativa, and acne, type 2 inflammation is less represented, and pruritus is milder or variable. Th2 inflammation and immunity evolved to protect against parasites, and thus, the scratching response evoked by pruritus might have developed to alert about the presence and to remove parasites from the skin surface.

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Section: Scabiesmentioning

confidence: 99%

Pruritus as a Distinctive Feature of Type 2 Inflammation

et al. 2021

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“…To the Editor, Crusted scabies (Norwegian), a rare (<0.1% prevalence) and severe form of scabies associated with a lower grade of itch, especially apparent in immunosuppressed individuals and generalized form. 1 We report two instances of localized crusted scabies in the areas of cutaneous engraftment in immunocompetent individuals, probably the first to be reported in the literature.…”

Section: Localized Scabies Crustose Over the Engrafted Skin: Report O...mentioning

confidence: 82%

Localized scabies crustose over the engrafted skin: Report of two cases

Ahmed

Rahim

et al. 2022

J of Cosmetic Dermatology

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“…In this visit, an evaluation of the initial treatment was carried out and pus wounds obtained in patient K has dried up and itchy complaints no longer exist. Besides, there were no lesions in other limbs and provide re-education about scabies and remind about the importance maintaining personal hygiene (El-Moamly, 2021;Ständer & Ständer, 2021;Wochebo et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

Management of Scabies Cases with Secondary Infection in Children through Family Medicine Approach

et al. 2022

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Scabies is a skin infestation caused by Sarcoptes scabiei (var. hominis). The prevalence of scabies in Indonesia is 4.60% - 12.95% and ranks the third most common disease. The Cikupa Public Health Center experienced an increase in the number of new scabies cases as many as 34 new cases in January - June 2022 compared to June - December 2021 as many as 21 new cases. Female patient aged 5 years and 10 months suffered from scabies with secondary infection and had transmitted it to other family members. Problem analysis was carried out by mapping the Mandala of Health with the principles of family medicine and comprehensive management. Ms. K and her family members recovered from scabies and no new lesions appeared. The patient and her families have been given education about scabies and there are no new infections in them so further transmission of scabies can be prevented. The family medicine approach and Mandala of Health have helped Ms. K and her family in the treatment and eradication of scabies.

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Itch in Scabies—What Do We Know?

Cited by 14 publications

References 55 publications

Pruritus as a Distinctive Feature of Type 2 Inflammation

Pruritus as a Distinctive Feature of Type 2 Inflammation

Localized scabies crustose over the engrafted skin: Report of two cases

Management of Scabies Cases with Secondary Infection in Children through Family Medicine Approach

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