Isoquinoline alkaloids as prolyl oligopeptidase inhibitors

Modulatory Effects ofEschscholzia californicaAlkaloids on Recombinant GABAAReceptors

“…Our choice of studying NMT and reticuline comes from the fact that the “NMT fraction” (see Section 3.2 ) manifested mild sedative effects on mice. On the other hand, much more abundant californidine (a quaternary pavine alkaloid) is unable to penetrate the brain-blood barrier [ 32 ] and, therefore, was not included in our electrophysiological study. The main goal of the present work was to identify the mechanism by which E. californica alkaloids could induce sedative effects.…”

Chemical Composition and Enzyme Inhibitory Activities of Turkish Pancratium maritimum Bulbs

“…The enzyme activity was assayed using a colorimetric method of Yoshimoto and Cahlikova et al 26,27 with the following modifications. The enzyme (0.2 U/mL) was dissolved in sodium phosphate buffer.…”

“…24,25 Thus, the presence of lycorine and galanthamine type alkaloids in the tested P. maritimum extract could be responsible for their high anticholinesterase activity. Prolyl oligopeptidase inhibitory activity was carried out using a modified colorimetric method, 26,27 which is reported here for the genus Pancratium for the first time. The extract of P. maritimum bulbs showed POP inhibitory activity with an IC 50 value of 78 µg/mL.…”

Pharmacological effects of berberine on mood disorders

“…In recent years, prolyl oligopeptides (POPs) have gained prominence as targets for the treatment of bipolar affective disorder . POP has been reported to participate in the processing of neuropeptide precursors . Moreover, neuroprotective effects of POPs inhibitors have been reported in experimental animals .…”

“…Berberine does not display any genotoxic, cytotoxic, or mutagenic activity . However, berberine has remarkable cytotoxicity on a wide range of cancer cell lines because of its protoberberine skeleton . Standard doses of berberine are usually well‐tolerated and adverse reactions are rare.…”