Pharmacological effects of berberine on mood disorders

Fan, Jie; Zhang, Kun; Jin, Yang; Li, Bingjini; Gao, Shengxiang; Zhu, Jiaming; Cui, Ranji

doi:10.1111/jcmm.13930

Cited by 67 publications

(49 citation statements)

References 93 publications

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“…Berberine is another naturally occurring compound with great therapeutic and biological activities in clinical trials, in vivo and in vitro experiments [134,135]. The effects of berberine on mitochondria are associated with anti-tumor and protective activities of berberine.…”

Section: Regulation Of Mitochondria By Plant-derived Chemicalsmentioning

confidence: 99%

Natural products and phytochemical nanoformulations targeting mitochondria in oncotherapy: an updated review on resveratrol

et al. 2020

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Mitochondria are intracellular organelles with two distinct membranes, known as an outer mitochondrial membrane and inner cell membrane. Originally, mitochondria have been derived from bacteria. The main function of mitochondria is the production of ATP. However, this important organelle indirectly protects cells by consuming oxygen in the route of energy generation. It has been found that mitochondria are actively involved in the induction of the intrinsic pathways of apoptosis. So, there have been efforts to sustain mitochondrial homeostasis and inhibit its dysfunction. Notably, due to the potential role of mitochondria in the stimulation of apoptosis, this organelle is a promising target in cancer therapy. Resveratrol is a non-flavonoid polyphenol that exhibits significant pharmacological effects such as antioxidant, anti-diabetic, anti-inflammatory and anti-tumor. The anti-tumor activity of resveratrol may be a consequence of its effect on mitochondria. Multiple studies have investigated the relationship between resveratrol and mitochondria, and it has been demonstrated that resveratrol is able to significantly enhance the concentration of reactive oxygen species, leading to the mitochondrial dysfunction and consequently, apoptosis induction. A number of signaling pathways such as sirtuin and NF-κB may contribute to the mitochondrial-mediated apoptosis by resveratrol. Besides, resveratrol shifts cellular metabolism from glycolysis into mitochondrial respiration to induce cellular death in cancer cells. In the present review, we discuss the possible interactions between resveratrol and mitochondria, and its potential application in cancer therapy.

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Section: Regulation Of Mitochondria By Plant-derived Chemicalsmentioning

confidence: 99%

Natural products and phytochemical nanoformulations targeting mitochondria in oncotherapy: an updated review on resveratrol

et al. 2020

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“…i.p. 20 or 30 mg/kg of BBR administered in mice was found effective upon the oral administration and exhibited a noticeable increase in the neurotransmitters level (Fan et al, ). Based on this observation, lower effective doses of PLT could be related to its different chemical structure.…”

Section: Pharmacology Of Pltmentioning

confidence: 99%

Palmatine: A review of pharmacological properties and pharmacokinetics

Tarabasz¹,

Kukuła-Koch

2019

Phytotherapy Research

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The aim of this review is to collect together the results of the numerous studies over the last two decades on the pharmacological properties of palmatine published in scientific databases like Scopus and PubMed, which are scattered across different publications. Palmatine, an isoquinoline alkaloid from the class of protoberberines, is a yellow compound present in the extracts from different representatives of Berberidaceae, Papaveraceae, Ranunculaceae, and Menispermaceae. It has been extensively used in traditional medicine of Asia in the treatment of jaundice, liver‐related diseases, hypertension, inflammation, and dysentery. New findings describe its possible applications in the treatment of civilization diseases like central nervous system‐related problems. This review intends to let this alkaloid come out from the shade of a more frequently described alkaloid: berberine. The toxicity, pharmacokinetics, and biological activities of this protoberberine alkaloid will be developed in this work.

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“…Processed CC products are reported to exert ameliorative effect on severe skin disease, dysentery, gastroenteritis and diabetes, etc Structure‐activity research draw a conclusion that isoquinoline alkaloids in CC, namely berberine, coptisine, palmatine, epiberberine and jatrorrhizine, are the main constituents responsible for its bioactive properties . By far, numerous systematic reviews have led to a summing‐up that berberine, the most in‐depth studied alkaloid of CC, exerts potent pharmacological efficacy in the treatment to mood disorders, tumour, type 2 diabetes mellitus, nerve damage as well as cardiovascular, hepatic and renal disorders . As the second most abundant isoquinoline alkaloid in CC, coptisine shares a same parent nucleus with berberine .…”

Section: Introductionmentioning

confidence: 99%

Coptisine from Coptis chinensis exerts diverse beneficial properties: A concise review

Luo

Deng

et al. 2019

J Cellular Molecular Medi

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Coptisine is a natural small‐molecular compound extracted from Coptis chinensis (CC) with a history of using for thousands of years. This work aimed at summarizing coptisine's activity and providing advice for its clinical use. We analysed the online papers in the database of SciFinder, Web of Science, PubMed, Google scholar and CNKI by setting keywords as ‘coptisine’ in combination of ‘each pivotal pathway target’. Based on the existing literatures, we find (a) coptisine exerted potential to be an anti‐cancer, anti‐inflammatory, CAD ameliorating or anti‐bacterial drug through regulating the signalling transduction of pathways such as NF‐κB, MAPK, PI3K/Akt, NLRP3 inflammasome, RANKL/RANK and Beclin 1/Sirt1. However, we also (b) observe that the plasma concentration of coptisine demonstrates obvious non‐liner relationship with dosage, and even the highest dosage used in animal study actually cannot reach the minimum concentration level used in cell experiments owing to the poor absorption and low availability of coptisine. We conclude (a) further investigations can focus on coptisine's effect on caspase‐1‐involved inflammasome assembling and pyroptosis activation, as well as autophagy. (b) Under circumstance of promoting coptisine availability by pursuing nano‐ or microrods strategies or applying salt‐forming process to coptisine, can it be introduced to clinical trial.

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Pharmacological effects of berberine on mood disorders

Cited by 67 publications

References 93 publications

Natural products and phytochemical nanoformulations targeting mitochondria in oncotherapy: an updated review on resveratrol

Natural products and phytochemical nanoformulations targeting mitochondria in oncotherapy: an updated review on resveratrol

Palmatine: A review of pharmacological properties and pharmacokinetics

Coptisine from Coptis chinensis exerts diverse beneficial properties: A concise review

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