“…Of the 14 components, some have been shown to have anti-atherosclerosis effects in previous studies.With the most targets, it can be found from the literature that the research on the anti-atherosclerosis effect of quercetin is also the most extensive.Quercetin can improves blood vessel structure by reducing serum lipids, oxidative stress factors, aortic contraction, weight gain and blood pressure, prevents the formation of arterial plaques through antioxidant activity [25] ,and fight atherosclerosis by enhancing autophagy in ApoE-/-mice [26] .Furthermore, in a high fructose-induced atherosclerosis mouse model, quercetin can attenuate atherosclerosis by inhibiting inflammation and apoptosis through the PI3K / AKT signaling pathway regulated by reactive oxygen species [27] .Both beta-sitosterol and stigmasterol belong to Phytosterols, and moderate intake of Phytosterols is considered to reduce plasma cholesterol and prevent atherosclerosis [28] .In addition, Lifsey HC et al reported that stigmasterol can promote the excretion of cholesterol in the small intestine [29] , while Chien MH et al reported that beta-sitosterol can inhibit the proliferation of vascular smooth muscle cells and has a potential role in anti-atherosclerosis [30] .In the rabbit model of atherosclerosis induced by high cholesterol, kaempferol can regulate the expression of inflammatory factors, showing an anti-atherosclerosis effect [31] .Ku SK et al reported that wogonin and baicalein blocked hyperglycaemic vascular inflammation by inhibiting NF-κB in human primary endothelial cell models, suggesting that they had a therapeutic effect on atherosclerosis [32] .Shi Y et al reported that berberine can delay the progression of atherosclerosis in ApoE-/-mice induced by high-fat diet and reduce the expression of inflammatory factors, which may be related to the regulated intestinal flora [33] .Other studies have shown that berberine down-regulates visfatin expression to inhibit endothelial dysfunction and improve diet-induced atherosclerosis in ApoE-/-mice [34] .Feng M et al reported that in the atherosclerosis model of ApoE-/-mice, the intervention of coptisine can reduce the level of blood lipid and down-regulate the expression of relevant inflammatory cytokines, thus reducing the area of atherosclerotic plaque [35] .Although no previous studies have directly shown that palmatine, berberrubine, acetacetin, oroxylin a paly a role of anti-atherosclerosis, studies have shown that they all have different degrees of effects of anti-inflammatory, lipid-lowering, and anti-oxidation,et alBerberrubine is the main metabolite of berberine in vivo. Studies have shown that it can reduce blood lipid ,inhibit the activity of intracellular xanthine oxidase, and has a potential role in treating endothelial dysfunction [36][37] .Palmatine and oroxylin a both have anti-inflammatory effects,and the former can reduce blood lipid levels, while the latter can also inhibit intracellular lipid accumulation [38][...…”