Isoprenylated Xanthone and Benzophenone Constituents of the Pericarp of <i>Garcinia planchonii</i>

Trinh, Duong H.; Ha, Ly Dieu; Tran, Phuong T.; Nguyen, Lien‐Hoa D.

doi:10.1177/1934578x1400901219

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…Plants of the genus Garcinia (Clusiaceae) are used worldwide in traditional medicine for the treatment of diseases and are well known to be rich sources of secondary metabolites such as xanthones, bioflavonoids, triterpenoids and benzophenones [1][2][3][4][5][6]. Phenolic constituents from Garcinia species have been reported to exhibit multiple pharmacological activities including antiinflammatory, antimicrobial, anti-HIV, antibacterial, antioxidant and anticancer [7][8][9][10][11][12][13].…”

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A Rapid Determination and Quantification of Three Biologically Active Polyisoprenylated Benzophenones using Liquid Chromatography-Tandem Mass Spectrometry (MRM) Method in Five Garcinia species from Cameroon

Biloa

Marti

et al. 2017

Natural Product Communications

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Following investigation of Garcinia genus, a sensitive, rapid and simple reversed-phase high performance liquid chromatography-electrospray ionization mass spectrometry method has been developed for the identification and quantification of three polyisoprenylated benzophenones, garcinol (1), isogarcinol (2) and 7-epi-clusianone (3), in the extracts of five Garcinia species from Cameroon. The separation of those compounds was achieved on a RP-18 column using a solvent system consisting of a mixture of acetonitrile-water-formic acid as a mobile phase in a gradient elution mode. The identification of the three compounds was determined on a triple quadripole mass spectrometer with ESI interface operating in the negative mode. A multiple reaction monitoring (MRM) method was developed for the quantification of these polyisoprenylated benzophenones in the extracts of the Garcinia species. The method was validated through intra-and inter-day precision, with the relative standard deviation (RSD) less than 6%, limits of detection (LOD) and limits of quantification (LOQ) <1 ng. Overall recoveries ranged from 94% to 104%, with RSDs ranging from 0.8% to 4.5%. The results indicated that the fruits of G. preussii and the roots of G. brevipedicellata are good source of garcinol (1) and isogarcinol (2) respectively.

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confidence: 99%

A Rapid Determination and Quantification of Three Biologically Active Polyisoprenylated Benzophenones using Liquid Chromatography-Tandem Mass Spectrometry (MRM) Method in Five Garcinia species from Cameroon

Biloa

Marti

et al. 2017

Natural Product Communications

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Xanthones from Garcinia Propinqua Roots

Meesakul

Pansanit

Maneerat

et al. 2016

Natural Product Communications

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Phytochemical investigation of Garcinia propinqua roots led to the isolation and identification of a new xanthone, doitunggarcinone D (1), together with 15 known compounds (2–16). Their structures were elucidated by intensive analysis of spectroscopic data. Compounds 3, 6, 7, 14, 15 and 16 exhibited strong antibacterial activity against Bacillus subtilis TISTR 088 with MIC values in the range of 1–4 μg/mL. Compounds 3, 7, 10 and 14 also showed good antibacterial activity against B. cereus TISTR 688 with MIC values ranging from 4–8 μg/mL.

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New Compounds and Potential Candidates for Drug Discovery from Medicinal Plants of Vietnam

Giang

Otsuka

2018

CHEMICAL & PHARMACEUTICAL BULLETIN

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The study of natural products introduces interesting new bioorganic structures and potential candidates for the drug discovery stage in the development of innovative drugs. Vietnam enjoys a broad biodiversity of native plant species, microorganisms, marine organisms, and a long tradition of using herbal remedies. Thus, the study of medicinal plants in determining the basis of their efficacy and safety is an important task for modern researchers in Vietnam. The present review covers literature on new compounds elucidated from the systematic study of medicinal plants within some popular genera in Vietnam, as well as their significant biological activities.

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Isoprenylated Xanthone and Benzophenone Constituents of the Pericarp of Garcinia planchonii

Cited by 4 publications

References 12 publications

A Rapid Determination and Quantification of Three Biologically Active Polyisoprenylated Benzophenones using Liquid Chromatography-Tandem Mass Spectrometry (MRM) Method in Five Garcinia species from Cameroon

A Rapid Determination and Quantification of Three Biologically Active Polyisoprenylated Benzophenones using Liquid Chromatography-Tandem Mass Spectrometry (MRM) Method in Five Garcinia species from Cameroon

Xanthones from Garcinia Propinqua Roots

New Compounds and Potential Candidates for Drug Discovery from Medicinal Plants of Vietnam

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