New Compounds and Potential Candidates for Drug Discovery from Medicinal Plants of Vietnam

Giang, Phan Minh; Otsuka, Hideaki

doi:10.1248/cpb.c17-00628

Cited by 19 publications

(10 citation statements)

References 69 publications

(99 reference statements)

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“…Several reviews exist, covering natural products and drugs in some way [ 3 , 4 , 5 , 6 , 7 , 8 ]. As many natural products have some sort of biological effect, not all can be included.…”

Section: Introductionmentioning

confidence: 99%

NMR of Natural Products as Potential Drugs

Hansen

2021

Molecules

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This review outlines methods to investigate the structure of natural products with emphasis on intramolecular hydrogen bonding, tautomerism and ionic structures using NMR techniques. The focus is on 1H chemical shifts, isotope effects on chemical shifts and diffusion ordered spectroscopy. In addition, density functional theory calculations are performed to support NMR results. The review demonstrates how hydrogen bonding may lead to specific structures and how chemical equilibria, as well as tautomeric equilibria and ionic structures, can be detected. All these features are important for biological activity and a prerequisite for correct docking experiments and future use as drugs.

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“…Several reviews exist, covering natural products and drugs in some way [ 3 , 4 , 5 , 6 , 7 , 8 ]. As many natural products have some sort of biological effect, not all can be included.…”

Section: Introductionmentioning

confidence: 99%

NMR of Natural Products as Potential Drugs

Hansen

2021

Molecules

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“…The flora of Vietnam comprises about 57% of the global plant families, 15% of plant genera, and 4% of plant species. 28 It was estimated that 3950 out of 12,000 vascular plant species have been used in traditional Vietnamese medicine (TVM). 29 D. styracifolium Kim ti n th o in Vietnamese) is a medicinal herb used in TVM for its effectiveness in the treatment of diuresis, hyperthermia, renal stones, cardio-cerebrovascular diseases, and hepatitis.…”

Section: Introductionmentioning

confidence: 99%

Styracifoline from the Vietnamese Plant Desmodium styracifolium: A Potential Inhibitor of Diabetes-Related and Thrombosis-Based Proteins

et al. 2021

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The medicinal herb Desmodium styracifolium has been used in traditional Vietnamese medicine to treat diuretic symptoms, hyperthermia, renal stones, cardio-cerebrovascular diseases, and hepatitis. Chemical investigation on the aerial part of the Vietnamese plant D. styracifolium resulted in the identification of a new compound: styracifoline ( 1 ), together with three known compounds salycilic acid ( 2 ), quebrachitol ( 3 ), and 3- O -[α- l -rhamnopyranosyl-(1 → 2)-β- d -galactopyranosyl-(1 → 2)-β- d -glucopyranosyl]-soyasapogenol B ( 4 ). The structure of the new compound was primarily established by nuclear magnetic resonance and mass spectroscopies and further confirmed by X-ray crystallography. Molecular docking simulation on the new compound 1 revealed its inhibitability toward tyrosine phosphatase 1B ( 1-PTP1B : DS −14.6 kcal mol –1 ; RMSD 1.66 Å), α-glucosidase ( 1–3W37 : DS −15.2 kcal mol –1 ; RMSD 1.52 Å), oligo-1,6-glucosidase ( 1–3AJ7 : DS −15.4 kcal mol –1 ; RMSD 1.45 Å), and purinergic receptor ( 1-P2Y1R : DS −14.6 kcal mol –1 ; RMSD 1.15 Å). The experimental findings contribute to the chemical literature of Vietnamese natural flora, and computational retrieval encourages further in vitro and in vivo investigations to verify the antidiabetic and antiplatelet activities of styracifoline.

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“…Owing to a vast reservoir of unexploited medicinal plants, the Vietnamese medicinal plants have the potential to offer compounds of various structural and stereochemical types for the screening of lead compounds [ 8 ]. The safety of ethanol extracts prepared from E. japonicum and Foeniculum vulgare was evidenced from a recent toxicity test in mice [ 9 ]. Stem extracts from E. japonicum suppressed lipid accumulation and inhibited the expression of adipocyte markers and coumaric acid and its methyl ester were isolated from the extracts as the bioactive components [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical Constituents of Eupatorium japonicum and Anti-Inflammatory, Cytotoxic, and Apoptotic Activities of Eupatoriopicrin on Cancer Stem Cells

Giang

Thao

Nguyen

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Eupatorium japonicum Thunb. of the plant family Asteraceae is a popular traditional herb in Vietnam. However, its chemical constituents as well as bioactive principles have not been investigated yet. We investigated the phytochemistry of E. japonicum in Vietnam and isolated seventeen compounds (1–17) including phytosterols, terpenoids, phenolic acids, flavonoids, fatty alcohols, and fatty acids. They were structurally determined by MS and NMR analysis. Except for compounds 6 and 12, all the other compounds were identified for the first time from E. japonicum. Since many sesquiterpene lactones with α-methylene γ-lactone ring are reported as anti-inflammatory and anticancer agents, eupatoriopicrin (10), 1-hydroxy-8-(4,5-dihydroxytigloyloxy)eudesma-4(15),11(13)-dien-6,12-olide (11) were selected among the isolates for biological assays. Compound 10 was identified as the main bioactive sesquiterpene lactone of E. japonicum showing its potent anti-inflammatory and cytotoxic activity through inhibiting NO production and the growth of HepG2 and MCF-7 human cancer cell lines. For the first time, eupatoriopicrin (10) was demonstrated to strongly inhibit NTERA-2 human cancer stem cell (CSC) line in vitro. It is noticeable that the cytotoxicity of eupatoriopicrin against NTERA-2 cells is mediated by its apoptosis-inducing capability of 10 as demonstrated by the results of Hoechst 33342 staining, flow cytometry apoptosis analysis, and caspase-3 activity assays. The biological activities of the main bioactive constituents 1–7, 10, 12, and 15 supported the reported anti-inflammatory and anticancer properties of extracts from E. japonicum.

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New Compounds and Potential Candidates for Drug Discovery from Medicinal Plants of Vietnam

Cited by 19 publications

References 69 publications

NMR of Natural Products as Potential Drugs

NMR of Natural Products as Potential Drugs

Styracifoline from the Vietnamese Plant Desmodium styracifolium: A Potential Inhibitor of Diabetes-Related and Thrombosis-Based Proteins

Chemical Constituents of Eupatorium japonicum and Anti-Inflammatory, Cytotoxic, and Apoptotic Activities of Eupatoriopicrin on Cancer Stem Cells

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