Chemical Constituents of Eupatorium japonicum and Anti-Inflammatory, Cytotoxic, and Apoptotic Activities of Eupatoriopicrin on Cancer Stem Cells

Giang, Phan Minh; Thao, Thi; Nguyen, Thi Nga; Do, Thi Viet Huong; Dong, Ngoc Phuc; Vu, Minh Trang

doi:10.1155/2021/6610347

Cited by 6 publications

(3 citation statements)

References 56 publications

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“…Until now, only a few studies have been reported on either the physiological activity or active ingredients of EJ. With respect to the major chemical constituents, a previous study identified fatty alcohols, acids, terpenes, phytosterols, phenolic acids, and flavonoids in EJ leaves ( Phan et al, 2021 ). However, the above-mentioned flavonoid glycosides confirmed in the present study appear to be the first identification of these components in EJ.…”

Section: Discussionmentioning

confidence: 99%

“…EJ is traditionally used to prepare prescriptions to treat various digestive diseases, nausea, vomiting, dyspepsia, and diarrhea ( Shin et al, 2018 ). Recently, the therapeutic efficacy of EJ against inflammatory reactions and its underlying mechanisms of action were investigated in RAW 264.7 monocytic, 293T kidney, and rheumatoid arthritis fibroblast-like synovial cells ( Gu et al, 2014 ; Dai et al, 2020 ; Phan et al, 2021 ), and it was found that EJ may be useful for controlling and treating ISDs. However, the effects of EJ-mediated nanoparticles on ISDs have not yet been examined.…”

Section: Introductionmentioning

confidence: 99%

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Structural properties and anti-dermatitis effects of flavonoids-loaded gold nanoparticles prepared by Eupatorium japonicum

Moon²,

Kim³

et al. 2022

Front. Pharmacol.

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Recently, green synthesis-based nanoformulations using plants or microorganisms have attracted great interest because of their several advantages. Nanotechnology-based biological macromolecules are emerging materials with potential applications in cosmetics and medications for ameliorating and treating inflammatory skin diseases (ISDs). Eupatorium japonicum (EJ), a native Korean medicinal plant belonging to the family Asteraceae, has been traditionally used to prepare prescriptions for the treatment of various inflammatory diseases. EJ-based gold nanoparticles (EJ-AuNPs) were biosynthesized under optimal conditions and characterized their physicochemical properties using various microscopic and spectrometric techniques. Additionally, the effects of EJ-AuNPs on ISDs as well as their underlying mechanisms were investigated in the tumor necrosis factor-α/interferon-γ (T+I)-induced skin HaCaT keratinocytes. The MTT and live/dead cell staining assays showed that EJ-AuNP treatment was considerably safer than EJ treatment alone in HaCaT cells. Moreover, EJ-AuNP treatment effectively suppressed the production of T+I-stimulated inflammatory cytokines (RANTES, TARC, CTACK, IL-6, and IL-8) and intracellular reactive oxygen species, and such EJ-driven anti-inflammatory effects were shown to be associated with the downregulation of intracellular mitogen-activated protein kinase and nuclear factor-κB signaling pathways. The present study provides preliminary results and a valuable strategy for developing novel anti-skin dermatitis drug candidates using plant extract-based gold nanoparticles.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structural properties and anti-dermatitis effects of flavonoids-loaded gold nanoparticles prepared by Eupatorium japonicum

Moon²,

Kim³

et al. 2022

Front. Pharmacol.

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“…Depression affects approximately 4.4% of the global population and is characterized by persistent mood depression, physical symptoms, intellectual disability, cognitive impairment, and decreased activity. It not only has adverse effects on physical and mental health, but also increases social and economic burden[ 1 ]. While selective serotonin reuptake inhibitors, tricyclic antidepressants, and other Western medicine treatments have satisfactory clinical effectiveness, they also have significant side effects, such as dependency and withdrawal reactions[ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of acupuncture at ghost points combined with fluoxetine in treating depression: A randomized study

Wang¹,

Huang²,

Ablikim³

et al. 2022

WJCC

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BACKGROUND Depression affects more than 350 million people worldwide. In China, 4.2% (54 million people) of the total population suffers from depression. Psychotherapy has been shown to change cognition, improve personality, and enhance the ability to cope with difficulties and setbacks. While pharmacotherapy can reduce symptoms, it is also associated with adverse reactions and relapse after drug withdrawal. Therefore, there has been an increasing emphasis placed on the use of non-pharmacological therapies for depression. The hypothesis of this study was that acupuncture at ghost points combined with fluoxetine would be more effective than fluoxetine alone for the treatment of depression. AIM To investigate the efficacy of acupuncture at ghost points combined with fluoxetine for the treatment of patients with depression. METHODS This randomized controlled trial included patients with mild to moderate depression ( n = 160). Patients received either acupuncture at ghost points combined with fluoxetine ( n = 80) or fluoxetine alone (control group, n = 80). Needles were retained in place for 30 min, 5 times a week; three treatment cycles were administered. The Mann–Whitney U test was used to compare functional magnet resonance imaging parameters, Hamilton depression rating scale (HAMD) scores, and self-rating depression scale (SDS) scores between the acupuncture group and control group. RESULTS There were no significant differences in HAMD or SDS scores between the acupuncture group and control group, before or after 4 wk of treatment. The acupuncture group exhibited significantly lower HAMD and SDS scores than the control group after 8 wk of treatment ( P < 0.05). The acupuncture group had significantly lower fractional Amplitude of Low Frequency Fluctuations values for the left anterior wedge leaf, left posterior cingulate gyrus, left middle occipital gyrus, and left inferior occipital gyrus after 8 wk. The acupuncture group also had significantly higher values for the right inferior frontal gyrus, right insula, and right hippocampus ( P < 0.05). After 8 wk of treatment, the effective rates of the acupuncture and control groups were 51.25% and 36.25%, respectively ( P < 0.05). CONCLUSION The study results suggest that acupuncture at ghost points combined with fluoxetine is more effective than fluoxetine alone for the treatment of patients with mild to moderate depression.

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Aplydactylonins A-C, three new sesquiterpenes from the Vietnamese sea hare Aplysia dactylomela and their cytotoxicity

et al. 2021

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Chemical Constituents of Eupatorium japonicum and Anti-Inflammatory, Cytotoxic, and Apoptotic Activities of Eupatoriopicrin on Cancer Stem Cells

Cited by 6 publications

References 56 publications

Structural properties and anti-dermatitis effects of flavonoids-loaded gold nanoparticles prepared by Eupatorium japonicum

Structural properties and anti-dermatitis effects of flavonoids-loaded gold nanoparticles prepared by Eupatorium japonicum

Efficacy of acupuncture at ghost points combined with fluoxetine in treating depression: A randomized study

Aplydactylonins A-C, three new sesquiterpenes from the Vietnamese sea hare Aplysia dactylomela and their cytotoxicity

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