Isolation, characterization and function of the two cytochromes c of the yeast Candida parapsilosis

Camougrand, Nadine; Velours, Jean; Denis, Michel; Guérin, Martine

doi:10.1016/0005-2728(93)90135-3

Cited by 6 publications

(1 citation statement)

References 25 publications

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“…the obligate aerobe yeast Candida parapsilosis contains both the classical respiratory chain, an alternative ubiquinol oxidase and a parallel respiratory chain containing an alternative cytochrome c oxidase. 34,71,133 On the other hand, the residual molecular oxygen that is not reduced by the mitochondrial (classical or alternative) respiration is used by numerous anabolic pathways. Indeed, lipid, amino acid, vitamin, iron, haem and ubiquinone metabolisms involve oxygen-dependent steps.…”

Section: Oxygen Utilization By Eukaryotic Cellsmentioning

confidence: 99%

Role of the non‐respiratory pathways in the utilization of molecular oxygen by Saccharomyces cerevisiae

Rosenfeld

Beauvoit

2003

Yeast

132

110

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Saccharomyces cerevisiae is a facultative anaerobe devoid of mitochondrial alternative oxidase. In this yeast, the structure and biogenesis of the respiratory chain, on the one hand, and the functional interactions of oxidative phosphorylation with the cellular energetic metabolism, on the other, are well documented. However, to our knowledge, the molecular aspects and the physiological roles of the non-respiratory pathways that utilize molecular oxygen have not yet been reviewed. In this paper, we review the various non-respiratory pathways in a global context of utilization of molecular oxygen in S. cerevisiae. The roles of these pathways are examined as a function of environmental conditions, using either physiological, biochemical or molecular data. Special attention is paid to the characterization of the so-called 'cyanide-resistant respiration' that is induced by respiratory deficiency, catabolic repression and oxygen limitation during growth. Finally, several aspects of oxygen sensing are discussed.

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Section: Oxygen Utilization By Eukaryotic Cellsmentioning

confidence: 99%

Role of the non‐respiratory pathways in the utilization of molecular oxygen by Saccharomyces cerevisiae

Rosenfeld

Beauvoit

2003

Yeast

132

110

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Genetic Engineering for Improved Xylose Fermentation by Yeasts

Jeffries

Shi

1999

Recent Progress in Bioconversion of Lignocellulosics

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Biology and genetics of the pathogenic yeast Candida parapsilosis

et al. 2009

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The yeast Candida parapsilosis is an opportunistic human pathogen frequently associated with nosocomial infections in neonates and patients with diminished immunity. A growing number of studies powered by recent advances in molecular genetics and genomics provide a background for uncovering the molecular basis of its virulence that suggests promising avenues for therapeutic intervention against this pathogen. Importantly, these studies also revealed several unique genetic and physiological features absent in model organisms, such as baker's and fission yeasts. Hence, besides the clinical impact, C. parapsilosis represents an interesting non-conventional model suitable for investigations of several fundamental biological phenomena in cellular physiology, morphogenesis, and genome maintenance. In this study, we provide a concise review on C. parapsilosis biology and highlight its interesting biological features. In addition, we summarize approaches for genetic manipulation, which have enhanced research on this species by overcoming limitations of conventional genetic analysis caused primarily by an apparent absence of a sexual cycle and the diploid state of its genome.

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Isolation, characterization and function of the two cytochromes c of the yeast Candida parapsilosis

Cited by 6 publications

References 25 publications

Role of the non‐respiratory pathways in the utilization of molecular oxygen by Saccharomyces cerevisiae

Role of the non‐respiratory pathways in the utilization of molecular oxygen by Saccharomyces cerevisiae

Genetic Engineering for Improved Xylose Fermentation by Yeasts

Biology and genetics of the pathogenic yeast Candida parapsilosis

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