Isolation and biological characterization of a 6-kDa protein from hepatopancreas of lobster Panulirus argus with insulin-like effects

Insulin‐like genes in ascidians: Findings in Ciona and hypotheses on the evolutionary origins of the pancreas

“…The general consensus on the evolutionary origins of the pancreas is that insulin‐producing beta‐cells are the essential and most primitive components of its endocrine division (Madsen, ). This hypothesis is supported by the findings of insulin and IGF in the hepatopancreas of molluscs (Chung, ; Gallardo et al ., ), and by our findings in Ciona , where the existence of glucagon, amylin, pancreatic peptide, ghrelin, and somatostatin has not been confirmed. The diffused expression of Ci‐INSL‐2 argues against the existence of a discrete endocrine pancreatic region in Ciona .…”

Discovery of a novel insulin-like peptide and insulin binding proteins in the Eastern rock lobster Sagmariasus verreauxi

“…As it stands, there is clear evidence of the glycostatic and anabolic effects of ectopic insulin and IGF-I administered to decapod crustaceans: including the lobster, Homarus americanus (Sanders, 1983a); crayfish Cherax quadricarinatus (Chaulet et al, 2012;Richardson et al, 1997); and shrimp Litopenaeus vannamei (Gutiérrez et al, 2007). Furthermore, the presence of putative ILPs has been demonstrated via insulin immunoreactivity in H. americanus (Sanders, 1983b) and the isolation of a 6 kDa protein with metabolic effects in the hepatopancreas of Panulirus argus (Gallardo et al, 2003).…”

A putative endocrine factor SIBD (single insulin binding domain protein) involved in immune response of Chinese mitten crab Eriocheir sinensis

“…Recently, some conserved components of GH/IGF axis were identified in invertebrate, such as insulin, IGFs and IGFRs [6,16,[26][27][28][29]. But the presence of IGFBPs in invertebrate has not been demonstrated so far [30].…”